ANTI-COFILIN

CAS No.
Chemical Name:
ANTI-COFILIN
Synonyms
Anti-CFL2;ANTI-COFILIN;Anti-HGNC:1875;COFILIN ANTIBODY;Anti-cofilin 2 (muscle);Anti-Cofilin antibody produced in rabbit;Monoclonal Anti-CFL2 antibody produced in mouse;Anti-Cofilin 2 (muscle) antibody produced in goat
CBNumber:
CB6198897
Molecular Formula:
Molecular Weight:
0
MDL Number:
MFCD03791485
MOL File:
Mol file
Last updated:2023-04-23 13:52:06

ANTI-COFILIN Properties

storage temp. -20°C
form buffered aqueous solution

ANTI-COFILIN price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich WH0001073M3 Monoclonal Anti-CFL2 antibody produced in mouse clone 6G9, purified immunoglobulin, buffered aqueous solution 100μg $524 2024-03-01 Buy
Sigma-Aldrich SAB4500148 Anti-Cofilin antibody produced in rabbit affinity isolated antibody 100μg $506 2024-03-01 Buy
Sigma-Aldrich SAB2500255 Anti-Cofilin 2 (muscle) antibody produced in goat affinity isolated antibody, buffered aqueous solution 100μg $568 2024-03-01 Buy
Sigma-Aldrich C8736 Anti-Cofilin antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution 0.2mL $569 2024-03-01 Buy
Biorbyt Ltd orb5891 cofilin antibody Affinity purified by Protein A 200μg $654.5 2021-12-16 Buy
Product number Packaging Price Buy
WH0001073M3 100μg $524 Buy
SAB4500148 100μg $506 Buy
SAB2500255 100μg $568 Buy
C8736 0.2mL $569 Buy
orb5891 200μg $654.5 Buy

ANTI-COFILIN Chemical Properties,Uses,Production

Uses

Anti-Cofilin antibody has been used in western blotting.

Uses

Anti-Cofilin antibody has been used:

  • for immunostaining of chick neurons. It is used as a primary antibody
  • for western blotting of protein isolated from mouse hippocampi cells, rat brain samples, human acute lymphoblastic T-cell line, human brain samples, head and neck squamous cell carcinoma cell line, HEK293T cells and renal epithelial cell lines
  • for immunofluorescence studies in tissue samples from human brain

General Description

Cofilin is a small phosphoinositide-sensitive actin-binding protein capable of depolymerizing actin-filaments in vitro. In mammals it has two isoforms: non-muscle (NM-CF, CF-L1) and muscle (M-CF, CF-L2). The protein is ubiquitiously present in tissues of eukaryotes and is especially abundant in neuronal tissues. It can shuttle between the cytoplasm and the nucleus in response to various stresses or signals, and may translocate from the cytoplasm to the plasma membrane in various cells.

Biochem/physiol Actions

Cofilin binds stoichiometrically to monomeric G-actin and actin protomers. Cofilin intercalates between longitudinally associated actin monomers within the filament. Under specific conditions, It cleaves the filaments and accelerates actin subunits dissociation from their ‘pointed′ ends. It is essential for viability and vital for many cellular processes involving actin remodeling, such as motility at the leading edge of cells, polarized cell growth, endocytosis, phagocytosis, cellular activation, cytokinesis etc. Cofilin activity is regulated through reversible phosphorylation and dephosphorylation. In phosphorylated form, it is inactive and unable to bond with actin. Phosphorylation of cofilin is regulated by at least four protein kinases: LIM Kinase-1, LIM Kinase-2, Testicular Kinase-1, and Testicular Kinase-2. S-nitrosylation of cofilin is involved in vascular endothelial growth factor (VEGF)-stimulated endothelial cytoskeleton remodeling and migration. Over-expression of cofilin suppresses growth and invasion of non-small cell lung cancer. Dysregulation of cofilin is associated with neurodegeneration.

ANTI-COFILIN Preparation Products And Raw materials

Raw materials

Preparation Products

ANTI-COFILIN Suppliers

Global( 40)Suppliers
Supplier Tel Email Country ProdList Advantage
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Absin Bioscience Inc. 021-38015121 15000105423 wulan@absin.cn China 24734 58
Shanghai Bohu Biotechnology Co., LTD 021-57763112 13585886131 3004987436@qq.com China 9694 58
ANTI-COFILIN COFILIN ANTIBODY Anti-Cofilin antibody produced in rabbit Anti-CFL2 Anti-Cofilin 2 (muscle) antibody produced in goat Anti-HGNC:1875 Anti-cofilin 2 (muscle) Monoclonal Anti-CFL2 antibody produced in mouse Alphabetical Index Antibodies to Actin-associated Proteins/MyosinAntibodies Antibodies to Cytoskeleton Cell Biology CO-CZ