Narasin
- CAS No.
- 58331-17-2
- Chemical Name:
- Narasin
- Synonyms
- NARASIN;henanamycin;Hainan drug;HainanMycin;Narasin sodiuM;naransin sodium;Naracin sodium salt;Narasin (sodium salt);4-MethylsalinoMycin sodiuM;Salinomycin, 4-methyl-, monosodium salt, (4S)-
- CBNumber:
- CB62130994
- Molecular Formula:
- C43H71O11Na
- Molecular Weight:
- 789.04
- MDL Number:
- MFCD06411262
- MOL File:
- 58331-17-2.mol
storage temp. | Store at -20°C |
---|---|
solubility | Soluble in DMSO |
form | solid |
FDA 21 CFR | 556.428; 558.363; 558.4 |
FDA UNII | DZY9VU539P |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
NFPA 704 |
|
Narasin price More Price(7)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 19447 | Narasin (sodium salt) ≥98% | 58331-17-2 | 5mg | $124 | 2024-03-01 | Buy |
Cayman Chemical | 19447 | Narasin (sodium salt) ≥98% | 58331-17-2 | 25mg | $556 | 2024-03-01 | Buy |
TRC | N378773 | NarasinSodium | 58331-17-2 | 5mg | $305 | 2021-12-16 | Buy |
Usbiological | 018018 | Narasin | 58331-17-2 | 1mg | $375 | 2021-12-16 | Buy |
TRC | N378773 | NarasinSodium | 58331-17-2 | 1mg | $120 | 2021-12-16 | Buy |
Narasin Chemical Properties,Uses,Production
Uses
Narasin sodium is an antibacterial and limited antifungal agent.
Uses
Narasin sodium is prepared from narasin taking advantage of the carboxylic acid which ionises and readily forms the salt in sodium hydroxide solutions. Narasin shows broad spectrum activity against Gram positive bacteria including anaerobes and mycoplasma, and also possesses antiviral and limited antifungal activity. Narasin is used in the animal health industry as an in-feed antibiotic and growth promotant.
brand name
Monteban (Lilly).
Biological Activity
narasin, isolated from certain streptomyces sp. is an ionophore antibiotic. as a coccidiostat, it can be used in veterinary practice for gastrointestinal parasites. narasin has been shown to induce tumor necrosis factor-related apoptosis-induced ligand (trail)-mediated apoptosis by er stress in glioma cells and to dampen nf-κb signaling by suppressing the phosphorylation of iκbα. nf-κb, as a transcription factor, plays a vital role across many cellular processes which are involved in neuronal and embryonic development, cell proliferation, apoptosis, and immune responses to infection and inflammation.
in vitro
narasin caused suicidal erythrocyte death or eryptosis. when human erythrocytes were exposed to narasin, it was shown that narasin resulted in the increase of annexin-v-binding indicating cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface and the decrease of forward scatter reflecting cell shrinkage, which indicated the death of erythrocyte [1]. narasin blocked nf-κb signaling via inhibition of iκbα phosphorylation at a lower concentration [2].
in vivo
new zealand white rabbits were given narasin 4-48 p. p. m, in pelleted feed. after 4 weeks, the experiments indicated that narasin protected rabbits from severe coccidiosis induced by e. flavescens, e. perforans e. magna, e. intestinalis, and e. stiedai. in addition, narasin reduced oocyst output in a highly effective fashion [3].
IC 50
3.2 μm: blocks nf-κb signaling via inhibition of iκbα phosphorylation
References
[1]. bouguerra, g., bissinger, r., abbes, s., & lang, f. stimulation of eryptosis by narasin. cellular physiology and biochemistry. 2015; 37(5):1807-1816.
[2]. miller, s., huang, r., sakamuru, s., shukla, s., attene-ramos, m., & shinn, p. et al. identification of known drugs that act as inhibitors of nf-κb signaling and their mechanism of action. biochemical pharmacology. 2010; 79(9): 1272-1280.
[3]. peeters, j., geeroms, r., antoine, o., mammerickx, m., & halen, p. efficacy of narasin against hepatic and intestinal coccidiosis in rabbits. parasitology. 1981; 83(02): 293-301.
Narasin Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12446 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20293 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8820 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29823 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23555 | 58 |
Dorne Chemical Technology co. LTD | +86-86-13583358881 +8618560316533 | Ethan@dornechem.com | China | 3137 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 | info@afinechem.com | China | 15394 | 58 |
BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
View Lastest Price from Narasin manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-16 | Narasin
58331-17-2
|
US $3.00-1.00 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | ||
2023-08-29 | Narasin
58331-17-2
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | ||
2021-08-14 | Narasin
58331-17-2
|
US $9.00 / KG | 1KG | 99 | 10tons | Shijiazhuang tongyang Import and Export Co., LTD |