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1,1-Dimethylbiguanide hydrochloride

Oral hypoglycemic agents Adverse effects and precautions Chemical Properties Application Production method
1,1-Dimethylbiguanide hydrochloride
1,1-Dimethylbiguanide hydrochloride
Chemical Name:
1,1-Dimethylbiguanide hydrochloride
Molecular Formula:
Formula Weight:
MOL File:

1,1-Dimethylbiguanide hydrochloride Properties

Melting point:
223-226 °C(lit.)
Flash point:
storage temp. 
Store at RT
Water Solubility 
Soluble in water (50 mg/ml), ethanol, and DMSO (50 mM).
CAS DataBase Reference
1115-70-4(CAS DataBase Reference)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,T,F
Risk Statements  22-36/38-39/23/24/25-23/24/25-11
Safety Statements  26-36-45-36/37-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
RTECS  DU1800000
Hazardous Substances Data 1115-70-4(Hazardous Substances Data)
Toxicity LD50 in rats (mg/kg): 1000 orally, 300 s.c. (Rx Bulletin)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P321 Specific treatment (see … on this label).
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.

1,1-Dimethylbiguanide hydrochloride price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 317240 Metformin 1115-70-4 5gm $112 2017-11-08 Buy
Sigma-Aldrich 1396309 Metformin hydrochloride United States Pharmacopeia (USP) Reference Standard 1115-70-4 200mg $410.4 2017-11-08 Buy
TCI Chemical M2009 Metformin Hydrochloride >98.0%(HPLC)(T) 1115-70-4 25g $64 2017-12-01 Buy
TCI Chemical M2009 Metformin Hydrochloride >98.0%(HPLC)(T) 1115-70-4 100g $191 2017-12-01 Buy
Alfa Aesar J63361 1,1-Dimethylbiguanide hydrochloride 1115-70-4 25g $86.4 2017-11-08 Buy

1,1-Dimethylbiguanide hydrochloride Chemical Properties,Uses,Production

Oral hypoglycemic agents

Metformin hydrochloride is a biguanide oral hypoglycemic agent , also known as  Glucophage,  its hypoglycemic effect is weaker than phenformin, the main role is to reduce the glucagon secretion of A cells ,and to promote the conversion of glucose to glycogen, its characteristic effect including that it does not  stimulate pancreatic β-cells to secrete insulin .
The follows are hypoglycemic mechanisms:
1. Increasing the sensitivity of peripheral tissues to insulin, increase insulin-mediated glucose utilization.
2. Increasing glucose utilization of non-insulin-dependent tissues, such as brain, blood cells, kidney medulla, intestine, skin and so on.
3. Inhibiting hepatic gluconeogenesis effect , reducing hepatic glucose output.
4. Inhibiting glucose uptake by intestinal cells.
5. Inhibiting the biosynthesis and storage of cholesterol , lowering blood triglycerides and total cholesterol levels.
Metformin hydrochloride is clinically used for the treatment of type Ⅱ diabetes patients who are not satisfied with simple diet control, especially patients with obesity and hyperinsulinemia, usage of this drug not only displays no hypoglycemic effect, but also there may be weight loss and hyperinsulinemia effect. For some patients with poor efficacy of sulfonylurea ,it may be effective, if it is used with hypoglycemic drugs including sulfonylurea, intestinal glucosidase inhibitors or thiazolidinediones, the results are better than used alone. It can also be used in patients with insulin therapy to reduce the amount of insulin.
At present, domestic manufacturer mainly include the American Shanghai Squibb Pharmaceutical Co., Ltd .

Adverse effects and precautions

Biguanide oral hypoglycemic agents can increase glucose utilization of surrounding tissues and inhibit the intestinal absorption of glucose, and inhibit glycogen gluconeogenesis and hepatic glucose output,it is mainly applied to obesity, dyslipidemia, type II diabetes patients. It almost has no hypoglycemic effect for normal persons ,  2 to 3 hours after taking for diabetes patients ,glucose decreases significantly.
Commonly used oral hypoglycemic agents include phenformin and metformin hydrochloride.
The incidence of adverse effects of metformin hydrochloride is higher than tolbutamide , common gastrointestinal reactions are anorexia, nausea, vomiting, abdominal pain, diarrhea, occasional metallic taste in the mouth, bad breath, nausea, loss of appetite and diarrhea and other gastrointestinal reactions, sometimes  hypoglycemia  is visible  .
Since the biguanide drugs enhance sugar anaerobic glycolysis, and inhibit  glycogen generation, small number of patients may suffer with ketosis or lactic acidosis, which should be particularly vigilant, but metformin effect is weak  , adverse reactions are only  1/50 of other biguanides, and it has rapid clearance, there are no accumulation in the liver, it rarely induces lactic acidosis, sometimes there is mild increase in blood lactate. patients with heart, liver, kidney diseases are prone to these adverse reactions, diabetes patients with these types of complications are hanged. It can reduce the absorption of vitamin B12, but it seldom causes anemia. The following cases are contraindications:
1. Pregnant and lactating women, children under 10 years of age, 80 years of age or older.
2. Diabetic ketoacidosis, diabetic hyperglycemic hyperosmolar syndrome, diabetes lactic acidosis.
3. Severe liver and kidney dysfunction, blood urea nitrogen and creatinine higher than normal, hypovolemic shock, heart failure, AMI, in vivo hypoxic condition such as heart failure, pulmonary insufficiency, or any systemic hypoxia circumstances and other serious heart and lung diseases.
4. Severe infection or trauma, major surgery, clinical hypotension , hypoxia and so on.
5. Complications with severe diabetic nephropathy and retinopathy. When there are symptoms,the drug  should be immediately discontinued; cimetidine can reduce the renal excretion of metformin hydrochloride, agar types can reduce the absorption of metformin, patients must check liver and kidney function and cardiac ketones regularly.
6. Alcoholics, vitamin B12 and folate deficiency which are not corrected.

Chemical Properties

White crystal or crystalline powder. Melting point 232 ℃ (218-220 ℃). Soluble in water, dissolved in methanol, slightly soluble in ethanol, insoluble in ether and chloroform. Odorless, bitter taste.


Production method

After the salifying of dimethylamine and the reaction with dicyandiamide , the product is derived.

Chemical Properties

Crystalline Solid


An oral hypoglycemic agent


Anti-diabetic and anti-cancer activity


ChEBI: A hydrochloride resulting from the reaction of metformin with one molar equivalent of hydrogen chloride.

Biological Activity

Antidiabetic agent; lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis via activation of the LKB1/AMPK pathway. Displays antiproliferative effects in cancer cell lines.

1,1-Dimethylbiguanide hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

1,1-Dimethylbiguanide hydrochloride Suppliers

Global( 328)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 CHINA 3218 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22144 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20803 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32765 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545 CHINA 511 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 CHINA 893 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 1428 55
career henan chemical co
+86-371-86658258 CHINA 10013 58
Target molecule Corp. 857-239-0968
857-239-8801 United States 2566 60
Chengdu HuaXia Chemical Reagent Co. Ltd 400-1166-196 QQ:800101999
028-84555506 QQ:800101999 China 9777 60

View Lastest Price from 1,1-Dimethylbiguanide hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 1,1-Dimethylbiguanide hydrochloride
US $1.00 / KG 1G 98% 100KG
2018-08-15 1,1-Dimethylbiguanide hydrochloride
US $2.00 / KG 1KG 98% 1ton

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