ChemicalBook >> CAS DataBase List >>MonoMethylauristatin F
MonoMethylauristatin F
- CAS No.
- 745017-94-1
- Chemical Name:
- MonoMethylauristatin F
- Synonyms
- MMAF;MonoMethylauristatin;F(MMAF);Tacrinum;745017-97-1;Methyloratatin F;MonoMethylauristatin F;Thiazole,2-bromo-6-methyl-;MMAF (MonoMethylauristatin F);MonoMethyl Auristatin F | MMAF
- CBNumber:
- CB62667922
- Molecular Formula:
- C39H65N5O8
- Molecular Weight:
- 731.96
- MDL Number:
- MFCD25976742
- MOL File:
- 745017-94-1.mol
- MSDS File:
- SDS
Last updated:2023-06-13 18:01:23
| Boiling point | 896.8±65.0 °C(Predicted) |
|---|---|
| Density | 1.116±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in DMSO |
| form | A solid |
| pka | 3.56±0.10(Predicted) |
| Stability | Hygroscopic |
| FDA UNII | 1Z1AI9IW5L |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
MonoMethylauristatin F price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 30197 | MMAF | 745017-94-1 | 25mg | $606 | 2024-03-01 | Buy |
| Cayman Chemical | 30197 | MMAF | 745017-94-1 | 50mg | $1062 | 2024-03-01 | Buy |
| Cayman Chemical | 30197 | MMAF | 745017-94-1 | 5mg | $153 | 2024-03-01 | Buy |
| Cayman Chemical | 30197 | MMAF | 745017-94-1 | 10mg | $275 | 2024-03-01 | Buy |
| TRC | M564805 | MonomethylAuristatinF | 745017-94-1 | 25mg | $745 | 2021-12-16 | Buy |
MonoMethylauristatin F Chemical Properties,Uses,Production
Description
MMAF (Monomethylauristatin F) is an effective tubulin polymerization inhibitor, used as an anti-tumor drug. MMAF (Monomethylauristatin F) is widely used as the cytotoxic component of antibody-conjugated drugs (ADCs), such as Vorsetuzumab mafodotin and SGN-CD19A.
Uses
Monomethyl Auristatin F is an antimicrotubule agent. A potent mitotic inhibitor.
Biological Activity
MMAF (Monomethylauristatin F) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin and SGN-CD19A.
Biotechnological Applications
MMAF is a new auristatin derivative with a charged C-terminal phenylalanine that attenuates its cytotoxic activity compared to its uncharged counterpart, Monomethyl auristatin E (MMAE). Because of MMAF is highly toxic, it cannot be used as a drug itself. MMAF induces potent antitumor effects when conjugated via protease cleavable linkers to a monoclonal antibody targeting internalizing, tumor-specific cell surface antigens. The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the anti-mitotic mechanism.
in vitro
MMAF inhibits anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O and Caki-1 cells with IC50s of 119, 105, 257 and 200 nM in vitro cytotoxicity assay.
Synthesis of MonoMethylauristatin F from L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl-
MonoMethylauristatin F Preparation Products And Raw materials
Raw materials
L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl-
L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl-, methyl ester
Preparation Products
Global( 198)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
| Alpha Biopharmaceuticals Co., Ltd | +86-411-39042497 +8613921981412 | sales@alphabiopharm.com | China | 886 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 6992 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5909 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
View Lastest Price from MonoMethylauristatin F manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-20 | Monomethyl auristatin F
745017-94-1
|
US $20.00 / g | 1g | 98% | 5KG | Wuhan Topule Biopharmaceutical Co., Ltd | |
 |
2023-05-23 | MonoMethylauristatin F
745017-94-1
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2021-07-13 | MMAF; Monomethylauristatin F
745017-94-1
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Monomethyl auristatin F
745017-94-1
- US $20.00 / g
- 98%
- Wuhan Topule Biopharmaceutical Co., Ltd
-
- MonoMethylauristatin F
745017-94-1
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- MMAF; Monomethylauristatin F
745017-94-1
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
745017-94-1(MonoMethylauristatin F)Related Search:
Fr
1,1,1-Trichlorotrifluoroethane
L-Phenylalanine
2,6-Di-tert-butyl-4-(dimethylaminomethyl)phenol
F4
(2R,3R)-N-((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)-3-Methoxy-2-Methyl-3-((S)-pyrrolidin-2-yl)propanaMide (hydrochloride)
VcMMAE
N-Boc-(2R,3R,4S)-dolaproine
(9H-fluoren-9-yl)Methyl ((S)-1-(((S)-1-(((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)aMino)-1-Methoxy-2-Methyl-3-oxopropyl)pyrrolidin-1-yl)-3-Methoxy-5-Methyl-1-oxoheptan-4-yl)(Methyl)aMino)-3-Methyl-1-oxobutan-2-yl)aMino)-3-Met
MonoMethyl auristatin E
1of4
MonoMethylauristatin F
MonoMethyl Auristatin F | MMAF
MMAF
(MonoMethylauristatin F)
(2S)-2-[[(2R,3R)-3-methoxy-3-[(2S)-1-[(3R,4S,5S)-3-methoxy-5-methyl-4-[methyl-[(2S)-3-methyl-2-[[(2S)-3-methyl-2-(methylamino)butanoyl]amino]butanoyl]amino]heptanoyl]pyrrolidin-2-yl]-2-methylpropanoyl]amino]-3-phenylpropanoic acid
(2S)-2-[[(2R,3R)-3-methoxy-3-[(2S)-1-[(3R,5S)-3-methoxy-5-methyl-4-[methyl-[(2S)-3-methyl-2-[[(2S)-3-methyl-2-(methylamino)butanoyl]amino]butanoyl]amino]heptanoyl]pyrrolidin-2-yl]-2-methylpropanoyl]amino]-3-phenylpropanoic acid
Monomethyl auristatin phenylalanine
MONOMETHYLAURISTATIN F; MMAF; MONOMETHYL AURISTATIN PHENYLALANINE; 745017-94-1
L-Phenylalanine, N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl-
F(MMAF)
745017-94-1 MonoMethylauristatin F
Tacrinum
MMAF
MonoMethylauristatin
Methyloratatin F
Thiazole,2-bromo-6-methyl-
MMAF (Synonyms: Monomethylauristatin F)
745017-97-1
(S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-Dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoic acid[Monomethylauristatin F
(S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-Dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoic acid
745017-94-1
75017-94-1
745017-97-1
ADCs