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UM729
- CAS No.
- 1448723-60-1
- Chemical Name:
- UM729
- Synonyms
- C07;UM729;CS-1240;UM-729;UM 729;UM729 USP/EP/BP;methyl 4-(3-(piperidin-1-yl)propylamino)-9H-pyrimido[4,5-b]indole-7-carboxylate;4-[[3-(1-Piperidinyl)propyl]amino]-9H-pyrimido[4,5-b]indole-7-carboxylic acid methyl ester;9H-Pyrimido[4,5-b]indole-7-carboxylic acid, 4-[[3-(1-piperidinyl)propyl]amino]-, methyl ester
- CBNumber:
- CB62715674
- Molecular Formula:
- C20H25N5O2
- Molecular Weight:
- 367.44
- MDL Number:
- MFCD28167784
- MOL File:
- 1448723-60-1.mol
Last updated:2023-03-13 11:54:02
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
UM729 Chemical Properties,Uses,Production
Biological Activity
UM729 is an enhancer of aryl hydrocarbon receptor (AhR) antagonists.
in vitro
um729 expands normal hematopoietic stem and progenitor cells (HSPC) in an AhR-independent manner, and UM729 inhibits AML cell differentiation. In 05H163 cells, the addition of UM729 increased CD34+CD15- Number of cells. It can inhibit the differentiation of most AML cells in combination with AhR antagonists.
in vivo
In NSG mice, UM729, alone or in combination with SR1, enhanced engraftment but not leukemia stem cell (LSC) frequency distribution.
UM729 Preparation Products And Raw materials
Raw materials
Preparation Products
1448723-60-1(UM729)Related Search:
UM729
C07
methyl 4-(3-(piperidin-1-yl)propylamino)-9H-pyrimido[4,5-b]indole-7-carboxylate
4-[[3-(1-Piperidinyl)propyl]amino]-9H-pyrimido[4,5-b]indole-7-carboxylic acid methyl ester
CS-1240
UM-729;UM 729
9H-Pyrimido[4,5-b]indole-7-carboxylic acid, 4-[[3-(1-piperidinyl)propyl]amino]-, methyl ester
UM729 USP/EP/BP
1448723-60-1
Inhibitors