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2-[(3-Amino-2-pyridinyl)methylene]-N,N-dimethyl-hydrazinecarbothioamide

2-[(3-Amino-2-pyridinyl)methylene]-N,N-dimethyl-hydrazinecarbothioamide Structure
2-[(3-Amino-2-pyridinyl)methylene]-N,N-dimethyl-hydrazinecarbothioamide structure
CAS No.
1184391-57-8
Chemical Name:
2-[(3-Amino-2-pyridinyl)methylene]-N,N-dimethyl-hydrazinecarbothioamide
Synonyms
3-AP-Me;2-[(3-Amino-2-pyridinyl)methylene]-N,N-dimethyl-hydrazinecarbothioamide;Hydrazinecarbothioamide, 2-[(3-amino-2-pyridinyl)methylene]-N,N-dimethyl-
CBNumber:
CB62750525
Molecular Formula:
C9H13N5S
Molecular Weight:
223.3
MDL Number:
MFCD28124396
MOL File:
1184391-57-8.mol
MSDS File:
SDS
Last updated:2023-05-04 15:12:19
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2-[(3-Amino-2-pyridinyl)methylene]-N,N-dimethyl-hydrazinecarbothioamide Properties

storage temp. 2-8°C
solubility DMSO: soluble20mg/mL, clear
form powder
color white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
Hazard Codes  Xn
Risk Statements  22-43
Safety Statements  26
WGK Germany  3

2-[(3-Amino-2-pyridinyl)methylene]-N,N-dimethyl-hydrazinecarbothioamide price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1055 3-AP-Me ≥98% (HPLC) 1184391-57-8 5mg $106 2024-03-01 Buy
Sigma-Aldrich SML1055 3-AP-Me ≥98% (HPLC) 1184391-57-8 25mg $370 2022-05-15 Buy
Product number Packaging Price Buy
SML1055 5mg $106 Buy
SML1055 25mg $370 Buy

2-[(3-Amino-2-pyridinyl)methylene]-N,N-dimethyl-hydrazinecarbothioamide Chemical Properties,Uses,Production

Biochem/physiol Actions

3-AP-Me is a dimethyl derivative of the ribonucleotide reductase inhibitor 3-AP (SML0568). 3-AP-Me is a potent inducer of ER stress and the unfolded protein response in cancer cell lines, incuding IRE1, PERK and ATF6 activity. Treatment with 3-AP-Me induces CHOP expression, phosphorylation of eIF2α, up-regulation of ATF4 and Bim, and causes mitochondrial membrane depolarization and apoptosis.

2-[(3-Amino-2-pyridinyl)methylene]-N,N-dimethyl-hydrazinecarbothioamide Preparation Products And Raw materials

Raw materials

Preparation Products

2-[(3-Amino-2-pyridinyl)methylene]-N,N-dimethyl-hydrazinecarbothioamide Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Supplier Advantage
Sigma-Aldrich 80
2-[(3-Amino-2-pyridinyl)methylene]-N,N-dimethyl-hydrazinecarbothioamide 3-AP-Me Hydrazinecarbothioamide, 2-[(3-amino-2-pyridinyl)methylene]-N,N-dimethyl- 1184391-57-8