Uses
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit .
Biochem/physiol Actions
NELFE (Negative elongation factor complex member E) is a major regulatory subunit of negative elongation factor (NELF) consisting of a conserved canonical βαββαβ RNA Recognition Motif (RRM). The RRM domain is mainly located at its β-sheet surface for identifying and binding to a wide variety of RNA sequences. It is mainly involved in the RNA Polymerase II (Pol II) transcript elongation. It directly binds to the nascent transcribed RNA for promoter-proximal RNA Pol II pausing of both HIV-1 and cellular genes. It has been suggested that NELFE may play a potential role in the prevention of hepatocellular carcinoma (HCC) cell metastasis.
