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ITI-722

ITI-722 Structure
ITI-722 structure
CAS No.
313368-91-1
Chemical Name:
ITI-722
Synonyms
Lumateperone;ITI-722;Lumateperone ITI-722;ITI-722 lumateperone;313368-91-1Lumateperone(ITI-007);1-(4-fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3‘,4‘:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)butan-1-one;1-(4-Fluorophenyl)-4-[(6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl]-1-butanone;1-(4-fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(9H)-yl)butan-1-one;1-Butanone, 1-(4-fluorophenyl)-4-[(6bR,10aS)-2,3,6b,9,10,10a-hexahydro-3-methyl-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl]-;presynaptic D2 receptor,dopamine D1 receptor,Serotonin Receptor,postsynaptic D2 receptor,Dopamine Receptor,5-HT2A,schizophrenia,ITI 007,Lumateperone,inhibit,Inhibitor,5-HT Receptor,5-hydroxytryptamine Receptor
CBNumber:
CB63032893
Molecular Formula:
C24H28FN3O
Molecular Weight:
393.5
MDL Number:
MFCD28502161
MOL File:
313368-91-1.mol
Last updated:2024-03-18 13:30:28
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ITI-722 Properties

Boiling point 556.4±50.0 °C(Predicted)
Density 1.26±0.1 g/cm3(Predicted)
pka 9.10±0.20(Predicted)
FDA UNII 70BSQ12069

ITI-722 Chemical Properties,Uses,Production

Physical Form

white solid

Description

Lumateperone is a novel antipsychotic agent with a unique mechanism of action with high 5-hydroxytryptamine 2A(5-HT2A) blocking activity. A Phase 2 study in treatment of insomnia revealed strong evidence of efficacy, with no impairment of next-day cognition.

Uses

Lumateperone was a drug developed for the treatment of schizophrenia. May have applications in bipolar depression.

storage

Store at 0-8℃

ITI-722 synthesis

313368-85-3
40862-32-6
313368-91-1
Synthesis of ITI-722 from (6bR,10aS)-3-Methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline and 4'-fluoro-4-iodobutyrophenone

ITI-722 Preparation Products And Raw materials

Raw materials

4'-fluoro-4-iodobutyrophenone 1H-Pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline, 2,3,6b,7,8,9,10,10a-octahydro-3-methyl- (6bR,10aS)-3-Methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline 4-FLUOROPHENYLMAGNESIUM BROMIDE 4-Chloro-4'-fluorobutyrophenone

Preparation Products

ITI-722 Suppliers

Global( 72)Suppliers
Supplier Tel Email Country ProdList Advantage
Chengdu Aupone Pharmaceutical Co.Ltd.
+86-28-+86-28-87843998-6060-6060 +8618631098571 lijiaqi@aupone.com China 43 58
shandong perfect biotechnology co.ltd 		+86-53169958659; +8618596095638 sales@sdperfect.com China 294 58
Nanjing Finetech Chemical Co., Ltd. 		025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Shanghai Jinghao Pharmaceutical Co.,Ltd 		+86-21-68900963 sales@jinghaopharma.com CHINA 153 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Career Henan Chemica Co 		+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
Senova Technology Co. Ltd. 		+86-0755-86703119 +8618503098836 info@senovatech.com China 349 58
Shanghai Innopharm Industrial Co., Ltd. 		+86-21-59960785 +86-17701845089 sales@hoyaopharm.com China 261 58
Supplier Advantage
Chengdu Aupone Pharmaceutical Co.Ltd.
58
shandong perfect biotechnology co.ltd 		58
Nanjing Finetech Chemical Co., Ltd. 		55
BOC Sciences 		58
Shanghai Jinghao Pharmaceutical Co.,Ltd 		58
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Senova Technology Co. Ltd. 		58
Shanghai Innopharm Industrial Co., Ltd. 		58

Related articles

View Lastest Price from ITI-722 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Lumateperone pictures 2024-03-18 Lumateperone
313368-91-1
 US $0.00 / gram 10gram 99.99 10Tons Chengdu Aupone Pharmaceutical Co.Ltd.
Lumateperone pictures 2024-03-12 Lumateperone
313368-91-1
 US $0.00 / g 1g 98% HPLC 100g shandong perfect biotechnology co.ltd
  • Lumateperone pictures
  • Lumateperone
    313368-91-1
  • US $0.00 / gram
  • 99.99
  • Chengdu Aupone Pharmaceutical Co.Ltd.
  • Lumateperone pictures
  • Lumateperone
    313368-91-1
  • US $0.00 / g
  • 98% HPLC
  • shandong perfect biotechnology co.ltd

ITI-722 Spectrum

ITI-722(313368-91-1)1HNMR
ITI-722 ITI-722 lumateperone 1-(4-fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3‘,4‘:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)butan-1-one 313368-91-1Lumateperone(ITI-007) 1-Butanone, 1-(4-fluorophenyl)-4-[(6bR,10aS)-2,3,6b,9,10,10a-hexahydro-3-methyl-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl]- 1-(4-fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(9H)-yl)butan-1-one 1-(4-Fluorophenyl)-4-[(6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl]-1-butanone Lumateperone presynaptic D2 receptor,dopamine D1 receptor,Serotonin Receptor,postsynaptic D2 receptor,Dopamine Receptor,5-HT2A,schizophrenia,ITI 007,Lumateperone,inhibit,Inhibitor,5-HT Receptor,5-hydroxytryptamine Receptor Lumateperone ITI-722 313368-91-1 C24H28FN3O API