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ChemicalBook >> CAS DataBase List >>7H-Purine-7-acetamide, 1,2,3,6-tetrahydro-1,3-dimethyl-N-(1-methylethyl)-N-[[(1-methylethyl)amino]carbonyl]-2,6-dioxo-

7H-Purine-7-acetamide, 1,2,3,6-tetrahydro-1,3-dimethyl-N-(1-methylethyl)-N-[[(1-methylethyl)amino]carbonyl]-2,6-dioxo-

7H-Purine-7-acetamide, 1,2,3,6-tetrahydro-1,3-dimethyl-N-(1-methylethyl)-N-[[(1-methylethyl)amino]carbonyl]-2,6-dioxo- Structure
7H-Purine-7-acetamide, 1,2,3,6-tetrahydro-1,3-dimethyl-N-(1-methylethyl)-N-[[(1-methylethyl)amino]carbonyl]-2,6-dioxo- structure
CAS No.
1372206-64-8
Chemical Name:
7H-Purine-7-acetamide, 1,2,3,6-tetrahydro-1,3-dimethyl-N-(1-methylethyl)-N-[[(1-methylethyl)amino]carbonyl]-2,6-dioxo-
Synonyms
2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-isopropyl-N-(isopropylcarbamoyl)acetamide;1,2,3,6-tetrahydro-1,3-dimethyl-N-(1-methylethyl)-N-[[(1-methylethyl)amino]carbonyl]-2,6-dioxo-7H-Purine-7-acetamide;7H-Purine-7-acetamide, 1,2,3,6-tetrahydro-1,3-dimethyl-N-(1-methylethyl)-N-[[(1-methylethyl)amino]carbonyl]-2,6-dioxo-
CBNumber:
CB64657954
Molecular Formula:
C16H24N6O4
Molecular Weight:
364.4
MDL Number:
MOL File:
1372206-64-8.mol
Last updated:2025-10-28 16:00:23
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7H-Purine-7-acetamide, 1,2,3,6-tetrahydro-1,3-dimethyl-N-(1-methylethyl)-N-[[(1-methylethyl)amino]carbonyl]-2,6-dioxo- Properties

Density 1.35±0.1 g/cm3(Predicted)
storage temp. 4°C, protect from light
solubility DMSO : 100 mg/mL (274.42 mM; Need ultrasonic)
pka 12.56±0.46(Predicted)
form Solid
color White to off-white

7H-Purine-7-acetamide, 1,2,3,6-tetrahydro-1,3-dimethyl-N-(1-methylethyl)-N-[[(1-methylethyl)amino]carbonyl]-2,6-dioxo- Chemical Properties,Uses,Production

Uses

THX-B is a potent and non-peptidic p75NTR (neurotrophin receptor p75) antagonist. THX-B can be used in the research of diabetic kidney disease, neurodegenerative and inflammatory disorders[1][2][3].

in vivo

THX-B (50 μg in 125 μL PBS, i.p. weekly for 4 weeks) improves bladder function in a mouse model of diabetic voiding dysfunction[3].
THX-B (2?μL of 2?μg/μL, IVT injection, a single dose) elicits a neuroprotective effect on photoreceptor cells in P17 rd10 mice[2].
THX-B (40 μg in 20 μL, IVT injection) resolves the inflammatory, vascular, and neurodegenerative phases of the retinal pathology[4].

Animal Model:Mouse model of diabetic voiding dysfunction
Dosage:50 μg in 125 μL PBS
Administration:Intraperitoneal injection (i.p.)
Result:Prevented bladder weight increase, which was 18% (95% CI 3%, 32%) and 37% (95% CI 14%, 60%) lower after 2 and 4 weeks of treatment.
Animal Model:P17 rd10 mice[1]
Dosage:2?μL of 2?μg/μL, single dose
Administration:Intravitreal (IVT) injected in one eye
Result:Increased the number of photoreceptor rows as well as the ONL/INL ratio.
Decreased the total number of microglial cells in the treated retinas, as well as some of the inflammatory signs, such as GFAP, α2M and the proinflammatory cytokines IL-1β and TNFα.

References

[1] Keren Ettinger, et al. Nerve growth factor stimulation of ERK1/2 phosphorylation requires both p75NTR and α9β1 integrin and confers myoprotection towards ischemia in C2C12 skeletal muscle cell model. Cell Signal. 2012 Dec;24(12):2378-88. DOI:10.1016/j.cellsig.2012.08.008
[2] María Platón-Corchado, et al. p75NTR antagonists attenuate photoreceptor cell loss in murine models of retinitis pigmentosa. Cell Death Dis. 2017 Jul 13;8(7):e2922. DOI:10.1038/cddis.2017.306
[3] Abubakr H Mossa, et al. Antagonism of proNGF or its receptor p75 NTR reverses remodelling and improves bladder function in a mouse model of diabetic voiding dysfunction. Diabetologia. 2020 Sep;63(9):1932-1946. DOI:10.1007/s00125-020-05222-4
[4] Alba Galan, et al. Subconjunctival Delivery of p75NTR Antagonists Reduces the Inflammatory, Vascular, and Neurodegenerative Pathologies of Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):2852-2862. DOI:10.1167/iovs.16-20988

7H-Purine-7-acetamide, 1,2,3,6-tetrahydro-1,3-dimethyl-N-(1-methylethyl)-N-[[(1-methylethyl)amino]carbonyl]-2,6-dioxo- Preparation Products And Raw materials

Raw materials

Preparation Products

7H-Purine-7-acetamide, 1,2,3,6-tetrahydro-1,3-dimethyl-N-(1-methylethyl)-N-[[(1-methylethyl)amino]carbonyl]-2,6-dioxo- Suppliers

Global( 7)Suppliers
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TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39035 58
Hangzhou IKSChem Technology Co., Limited 		+8613625816949 zheng@ikschem.com China 919 58
Suzhou Rovathin Foreign Trade Co.,Ltd 0512-65816829 18662214788 info@rovathin.com.cn China 9987 58
Shanghai Hecheng Medical Technology Co., LTD 13564747822 669027880@qq.com China 959 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 59936 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29257 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Hangzhou IKSChem Technology Co., Limited 		58
Suzhou Rovathin Foreign Trade Co.,Ltd 58
Shanghai Hecheng Medical Technology Co., LTD 58
Bide Pharmatech Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58

View Lastest Price from 7H-Purine-7-acetamide, 1,2,3,6-tetrahydro-1,3-dimethyl-N-(1-methylethyl)-N-[[(1-methylethyl)amino]carbonyl]-2,6-dioxo- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
THX-B pictures 2025-10-27 THX-B
1372206-64-8
 US $48.00 / mg 10g TargetMol Chemicals Inc.
  • THX-B pictures
  • THX-B
    1372206-64-8
  • US $48.00 / mg
  • TargetMol Chemicals Inc.
7H-Purine-7-acetamide, 1,2,3,6-tetrahydro-1,3-dimethyl-N-(1-methylethyl)-N-[[(1-methylethyl)amino]carbonyl]-2,6-dioxo- 1,2,3,6-tetrahydro-1,3-dimethyl-N-(1-methylethyl)-N-[[(1-methylethyl)amino]carbonyl]-2,6-dioxo-7H-Purine-7-acetamide 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-isopropyl-N-(isopropylcarbamoyl)acetamide 1372206-64-8