Anti-Vesicular Glutamate Transporter 3 (VGLUT3) Antibody

CAS No.
Chemical Name:
Anti-Vesicular Glutamate Transporter 3 (VGLUT3) Antibody
Synonyms
Anti-Vesicular Glutamate Transporter 3 (VGLUT3) Antibody
CBNumber:
CB64816847
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file

Anti-Vesicular Glutamate Transporter 3 (VGLUT3) Antibody price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich AB5421-I Anti-Vesicular Glutamate Transporter 3 (VGLUT3) Antibody serum, clone, from guinea pig 100μL $443 2024-03-01 Buy
Product number Packaging Price Buy
AB5421-I 100μL $443 Buy

Anti-Vesicular Glutamate Transporter 3 (VGLUT3) Antibody Chemical Properties,Uses,Production

Uses

Immunocytochemistry Analysis: A 1:250 dilution from a representative lot detected vesicular glutamate transporter 3 (VGluT3) in PC12 rat pheochromocytoma cells.

General Description

Vesicular glutamate transporter 3 (UniProt Q7TSF2; also known as Solute carrier family 17 member 8, VGluT3) is encoded by the Slc17a8 (also known as Vglut3) gene (Gene ID 266767) in rat species. Vesicular glutamate transporters (VGluTs) are proton-dependent carriers responsible for the upload of the major excitatory neurotransmitter glutamate into synaptic vesicles within presynaptic terminals to allow later regulated release at the synaptic cleft. Studies conducted in mice show that VGluT1 and VGluT2 are essential for vital functions, while Vglut3-knockout mice have a normal life expectancy despite being deaf and developing anxiety and discrete basal locomotor phenotypes. VGluT1- and VGluT2-expressing neurons represent the bulk of canonical glutamatergic neurons in the brain, with VgluT1 representing the major subtype and accounting for approximately 80% of total vesicular transport of glutamate in the brain. In contrast, VgluT3 is found in discrete population of non-glutamatergic neurons using other transmitters than glutamate, such as cholinergic interneurons in the dorsal and ventral striatum, subpopulations of GABAergic basket cells in the cortex and hippocampus, and serotoninergic neurons, where it is involved in more subtle modulation of local transmission. Rat VGluT3 is a 12-transmembrane (a.a. 77-97, 131-151, 154-174, 183-203, 222-242, 250-270, 315-335, 354-374, 391-411, 414-434, 448-468, 482-502) protein with 7 cytoplasmic and 6 vacuolar domains, having both its N- and C-terminal tails (a.a. 1-76 and 503-585) exposed at the cytoplasmic side.

Anti-Vesicular Glutamate Transporter 3 (VGLUT3) Antibody Preparation Products And Raw materials

Raw materials

Preparation Products

Anti-Vesicular Glutamate Transporter 3 (VGLUT3) Antibody Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Supplier Advantage
Sigma-Aldrich 80
Anti-Vesicular Glutamate Transporter 3 (VGLUT3) Antibody