Tigilanol tiglate
- CAS No.
- 943001-56-7
- Chemical Name:
- Tigilanol tiglate
- Synonyms
- EBC46;EBC 46;EBC-46;Tigilanol tiglate;(1cS,2aR,3S,3aS,6bR,7R,8R,8aS)-3,3a,6b-trihydroxy-2a-(hydroxymethyl)-1,1,5,7-tetramethyl-8a-((2-methylbutanoyl)oxy)-4-oxo-1a;2-Butenoic acid, 2-methyl-, (1aR,1bR,1cS,2aR,3S,3aS,6aS,6bR,7R,8R,8aS)-1a,1b,1c,2a,3,3a,4,6a,6b,7,8,8a-dodecahydro-3,3a,6b-trihydroxy-2a-(hydroxymethyl)-1,1,5,7-tetramethyl-8a-[(2S)-2-methyl-1-oxobutoxy]-4-oxo-1H-cyclopropa[5',6']benz[1',2':7,8]azuleno[5,6-b]oxiren-8-yl ester, (2E)-
- CBNumber:
- CB64848224
- Molecular Formula:
- C30H42O10
- Molecular Weight:
- 562.65
- MDL Number:
- MOL File:
- 943001-56-7.mol
| Boiling point | 682.1±55.0 °C(Predicted) |
|---|---|
| Density | 1.35±0.1 g/cm3(Predicted) |
| pka | 10?+-.0.70(Predicted) |
| InChIKey | YLQZMOUMDYVSQR-FOWZUWBHSA-N |
| SMILES | C(O[C@H]1[C@@]2(OC(=O)[C@@H](C)CC)C(C)(C)[C@@]2([H])[C@]2([H])[C@]3([H])O[C@]3(CO)[C@@H](O)[C@@]3(O)[C@@]([H])(C=C(C)C3=O)[C@@]2(O)[C@@H]1C)(=O)/C(/C)=C/C |
| FDA UNII | R1ZJT87990 |
| NCI Drug Dictionary | tigilanol tiglate |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
Tigilanol tiglate Chemical Properties,Uses,Production
Description
Tigilanol tiglate is a novel small molecule drug approved in Europe for the intratumoural treatment of non-metastatic, unresectable canine mast cell tumours. In addition, Tigilanol tiglate is also used for the treatment of multiple synchronous mast cell tumours in dogs and skin tumours in horses.
Uses
Tigilanol tiglate is a medication used to treat dogs with non-metastatic, skin-based (cutaneous) mast cell tumors (MCTs).
Definition
ChEBI: Tigilanol tiglate is a diterpenoid natural product isolated from the kernels of the Australian blushwood tree (Fontainea picrosperma). It is approved as a veterinary pharmaceutical for the treatment of non-metastatic and non-resectable canine mast cell tumours. It has a role as an antineoplastic agent, a plant metabolite and a protein kinase C agonist. It is a diterpenoid, a phorbol ester, a diester and an organic heteropentacyclic compound.
Mechanism of action
The active substance in Tigilanol tiglate stimulates the action of enzymes called protein kinase C which are involved in regulating processes that can help cells grow and survive. By activating these enzymes blood supply to cells gets interrupted, resulting in the death of the cell. By injecting Stelfonta into the tumour, cancer cells will be affected, so destroying the tumour, and leaving a wound at the injection site.
Tigilanol tiglate Preparation Products And Raw materials
Raw materials
Preparation Products
Tigilanol tiglate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hpets Biotech Company (Chongqing) Co.,ltd | +8613340353813 | info@hanpets.com | China | 26 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Shanghai AECOM Biotechnology Co. , Ltd. | 021-021-20956531 18116226605 | sui@neosunpharm.com | China | 350 | 55 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Supplier | Advantage |
|---|---|
| Hpets Biotech Company (Chongqing) Co.,ltd | 58 |
| TargetMol Chemicals Inc. | 58 |
| Shanghai AECOM Biotechnology Co. , Ltd. | 55 |
| TargetMol Chemicals Inc. | 58 |
View Lastest Price from Tigilanol tiglate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-02-27 | Tigilanol tiglate
943001-56-7
|
US $0.00 / kg | 1kg | 99% | 100 tons | Hpets Biotech Company (Chongqing) Co.,ltd |
-
- Tigilanol tiglate
943001-56-7
- US $0.00 / kg
- 99%
- Hpets Biotech Company (Chongqing) Co.,ltd