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CFI-401980

CFI-401980 structure

CAS No.: 1610676-27-1

Chemical Name:: CFI-401980

Synonyms: CFI-401980;CFI401980,CFI 401980;Benzamide, N-cyclopropyl-2-methyl-4-[2-phenoxy-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]pyrazolo[1,5-a]-1,3,5-triazin-8-yl]-

CBNumber:: CB64919751

Molecular Formula:: C28H30N6O3

Molecular Weight:: 498.58

MDL Number:

MOL File:: 1610676-27-1.mol

Last updated:2023-03-31 09:12:58

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CFI-401980 Properties

Density	1.40±0.1 g/cm3(Predicted)
pka	14.46±0.20(Predicted)

CFI-401980 Chemical Properties,Uses,Production

Description

CFI-401980 a potent and selective, novel class of TTK inhibitor (TKK Ki = 0.8 nM; HCT116 GI50 = 13 nM, rat PK: oral BA =97%). CFI-401980 demonstrate a strong anti-proliferative activity in a panel of human cancer cell lines (HCT116 GI50 < 15 nM) and good rodent pharmacokinetics (oral %F 97 %). TTK/Mps1 is a key kinase controlling progression of cell division via participation in the mitotic spindle assembly checkpoint and is overexpressed in a number of human cancers.

CFI-401980 Preparation Products And Raw materials

Raw materials

Preparation Products

CFI-401980 Suppliers

Global( 2)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	16377	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58

CFI-401980 CFI401980,CFI 401980 Benzamide, N-cyclopropyl-2-methyl-4-[2-phenoxy-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]pyrazolo[1,5-a]-1,3,5-triazin-8-yl]- 1610676-27-1