BVD 10
- CAS No.
- 262418-00-8
- Chemical Name:
- BVD 10
- Synonyms
- BVD 10;INPIYRLRY (MODIFICATIONS: TYR-9 = TYR-OME);L-Tyrosine, L-isoleucyl-L-asparaginyl-L-prolyl-L-isoleucyl-L-tyrosyl-L-arginyl-L-leucyl-L-arginyl-, methyl ester (9CI)
- CBNumber:
- CB6668499
- Molecular Formula:
- C58H92N16O13
- Molecular Weight:
- 1221.45
- MDL Number:
- MFCD06798324
- MOL File:
- 262418-00-8.mol
- MSDS File:
- SDS
BVD 10 price More Price(2)
BVD 10 Chemical Properties,Uses,Production
Biological Activity
ki: 25.7 nm for y1neuropeptide y (npy), a 36-residue peptide amide isolated originally from porcine brain, is a member of homologous hormone family including peptide yy (pyy) and pancreatic polypeptide (pp). it is the most abundant peptide in the mammalian brain and has been shown to exhibit a wide spectrum of central and peripheral activities. these actions are mediated by at least six g-protein coupled receptor subtypes denoted as y1, y2, y3, y4, y5, and y6. bvd 10 is a highly selective and potent neuropeptide y (npy) y1 receptor antagonists.
in vitro
the inability to form such hydrogen bonding in bvd 10 may prevent or perturb the c-terminus reverse turn, which may contribute, at least in part, to the increased y1 selectivity [1]. moreover, bvd 10 and its npy analogue peptide bvd15 were characterized conformationally. the two peptides exhibit different secondary structure characteristics in trifluoroethanol. molecular modeling studies suggested that the c-terminus tyr9 is oriented in different directions in the two peptides. the difference in the structures observed may contribute to the y1 selectivity of bvd 10 relative to bvd 15 [2].
References
[1] balasubramaniam a, dhawan vc, mullins de, chance wt, sheriff s, guzzi m, prabhakaran m, parker em. highly selective and potent neuropeptide y (npy) y1 receptor antagonists based on [pro(30), tyr(32), leu(34)]npy(28-36)-nh2 (bw1911u90). j med chem. 2001 may 10;44(10):1479-82.
[2] jois sd, balasubramaniam a. conformation of neuropeptide y receptor antagonists: structural implications in receptor selectivity. peptides. 2003 jul;24(7):1035-43.
BVD 10 Preparation Products And Raw materials
Raw materials
Preparation Products
BVD 10 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10247 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Zhejiang Hangyu API Co., Ltd | +8617531972939 | anna@api-made.com | China | 2944 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Creative Peptides | info@creative-peptides.com | United States | 6084 | 56 | |
| Nanjing Leon Biological Technology Co., Ltd. | 17705183659 | sales@njleonbiotech.com | China | 5503 | 55 |
| Nanjing Peptide Biotech Ltd. | 025-025-58361106-805-805 13082558573 | liugang@njpeptide.com | China | 9962 | 55 |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19105 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Hangzhou Go Top Peptide Biotech | 0571-88211921 13355716090 | Sales@gotopbio.com | China | 2835 | 58 |