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POLYDIMETHYLSILOXANE

POLYDIMETHYLSILOXANE
POLYDIMETHYLSILOXANE structure
CAS No.
8050-81-5
Chemical Name:
POLYDIMETHYLSILOXANE
Synonyms
phazyMe;Q 7-2587;HSDB 3906;ANTIFOAM A;SiMiticone;DCantifoamA;ANTIFOAM AF;Sab SiMplex;Aligest Plus;SilfoaM SE 2
CBNumber:
CB6696474
Molecular Formula:
(C2H6OSi)n
Formula Weight:
0
MOL File:
8050-81-5.mol

POLYDIMETHYLSILOXANE Properties

Density 
1 g/mL at 20 °C
vapor pressure 
5 mm Hg ( 20 °C)
refractive index 
n20/D 1.406
Flash point:
>101°C
storage temp. 
room temp
solubility 
Practically insoluble in water, very slightly soluble or practically insoluble in anhydrous ethanol, practically insoluble in methanol, partly miscible with ethyl acetate, with methylene chloride, with methyl ethyl ketone and with toluene.
form 
emulsion
color 
Colorless
EPA Substance Registry System
Simethicone (8050-81-5)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xn,Xi
Risk Statements  36/37-20-62
Safety Statements  26-36-23-36/37
WGK Germany  3
RTECS  TQ2690000
HS Code  3910000000

POLYDIMETHYLSILOXANE price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A6582 Antifoam A concentrate active silicone polymer 100% 8050-81-5 100 g $73.7 2021-03-22 Buy
Sigma-Aldrich A8011 Antifoam C Emulsion aqueous-silicone emulsion 8050-81-5 250ml $87.4 2021-03-22 Buy
Sigma-Aldrich 1612652 Simethicone 8050-81-5 50g $366 2020-08-18 Buy
Sigma-Aldrich A8011 Antifoam C Emulsion aqueous-silicone emulsion 8050-81-5 500ml $152 2021-03-22 Buy

POLYDIMETHYLSILOXANE Chemical Properties,Uses,Production

Chemical Properties

Viscous, greyish-white, opalescent liquid.

Chemical Properties

The PhEur 6.0 and USP 32 describe simethicone as a mixture of fully methylated linear siloxane polymers containing repeating units of the formula [–(CH3)2SiO–]n, stabilized with trimethylsiloxy endblocking units of the formula [(CH3)3 SiO–], and silicon dioxide. It contains not less than 90.5% and not more than 99.0% of the polydimethylsiloxane [–(CH3)2SiO–]n, and not less than 4.0% and not more than 7.0% of silicon dioxide. The PhEur 6.0 additionally states that the degree of polymerization is between 20–400.
Simethicone occurs as a translucent, gray-colored, viscous fluid. It has a molecular weight of 14 000–21 000.

Originator

Mylicon,Stuart,U.S.,1960

Uses

Simethicone is an oral anti-foaming agent used to reduce bloating, discomfort and pain caused by excess gas in the stomach or intestinal tract. Simethicone is a mixture of polydimethylsiloxane and hydrated silica gel.

Uses

Simethicone Emulsion USP is a water dilutable, non-ionic emulsion containing 30% Simethicone USP by weight. Highly stable over a broad pH range. Simethicones are used as anti foam agents in the manufacture of drugs. Their use in Pharmaceuticals is to comb

Production Methods

Silicon dioxide is initially rendered hydrophobic in one of a variety of proprietary processes specific to a particular manufacturer. It is then slowly mixed with the silicone fluids in a formulation. After mixing, the simethicone is milled to ensure uniformity.

Manufacturing Process

In a 5 liter three-necked flask, fitted with a reflux condenser, agitator and thermometer, were placed 1,393 g (9.41 mold) of redistilled (CH3)2Si(OEt)2 and 1,110 g (9.41 mols) of (CH3)3SiOEt. To this solution was added 254 g (14.11 mols) of water containing 7.5 g of NaOH (approximately 1 NaOH per 100 silicon atoms). This insured the formation of only straight chain polymers. The mixture was heated to 40°C and the temperature continued to rise for nearly an hour. After adding 50 cc (20% excess) more water, the mixture was refluxed for two hours and then allowed to stand overnight.
Alcohol was then distilled off, until the temperature reached 100°C. 1,706.6 g of distillate was collected. (Theory 1,430 g.) This alcohol was poured into four times its volume of water and an insoluble oil separated (457 g). The insoluble fraction was added back to the copolymer residue from the distillation and 555 cc of 20% hydrochloric acid was added. The acid mixture was refluxed for two hours, and the silicon oils were carefully washed with distilled water until neutral. The yield was 1,420 g. (Theory 1,409 g.)

brand name

Gas-X (Novartis); Mylanta Gas Relief (Johnson & Johnson-Merck Consumer); Mylicon Infant’s Drops (Johnson & Johnson-Merck Consumer); Sentry Simethicone (Witco); Sentry Simethicone Emulsion (Witco).

Therapeutic Function

Antiflatulent

Pharmaceutical Applications

The main use of simethicone as an excipient is as an antifoaming agent in pharmaceutical manufacturing processes, for which 1–50 ppm is used.
Therapeutically, simethicone is included in a number of oral pharmaceutical formulations as an antiflatulent, although its therapeutic benefit is questionable. It is also included in antacid products such as tablets or capsules. In some types of surgical or gastroscopic procedures where gas is used to inflate the body cavity, a defoaming preparation containing simethicone may be used in the area to control foaming of the fluids.
When simethicone is used in aqueous formulations, it should be emulsified to ensure compatibility with the aqueous system and components.
In the USA, up to 10 ppm of simethicone may be used in food products.

Safety

Simethicone is used in cosmetics, foods, and oral and topical pharmaceutical formulations, and is generally regarded as a relatively nontoxic and nonirritant material when used as an excipient. Direct contact with the eye may cause irritation.
Therapeutically, oral doses of 125–250mg of simethicone, three or four times daily, have been given as an antiflatulent. Doses of 20–40 mg of simethicone have been given with feeds to relieve colic in infants.
LD50 (dog, IV): 0.9 g/kg

storage

Simethicone is generally regarded as a stable material when stored in the original unopened container. A shelf-life of 18 months from the date of manufacture is typical. However, some simethicone products have a tendency for the silicon dioxide to settle slightly and containers of simethicone should therefore be shaken thoroughly to ensure uniformity of contents before sampling or use. Simethicone should be stored in a cool, dry, location away from oxidizing materials.
Simethicone can be sterilized by dry heating or autoclaving. With dry heating, a minimum of 4 hours at 160℃ is required.

Incompatibilities

Simethicone as supplied is not generally compatible with aqueous systems and will float like an oil on a formulation unless it is first emulsified. It should not be used in formulations or processing conditions that are very acidic (below pH 3) or highly alkaline (above pH 10), since these conditions may have some tendency to break the polydimethylsiloxane polymer. Simethicone cannot normally be mixed with polar solvents of any kind because it is very minimally soluble. Simethicone is incompatible with oxidizing agents.

Regulatory Status

GRAS listed. Included in the FDA Inactive Ingredients Database (oral emulsions, powders, solutions, suspensions, tablets; and rectal and topical preparations). Included in nonparenteral medicines licensed in the UK.

POLYDIMETHYLSILOXANE Preparation Products And Raw materials

Raw materials

Preparation Products


POLYDIMETHYLSILOXANE Suppliers

Global( 135)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21022 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
HEBEI YINGONG NEW MATERIAL TECHNOLOGY CO.,LTD
+8619933070948
claire@hbyingong.com China 408 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
career henan chemical co
13203830695 0086-371-86658258
0086-371-86658258 factory@coreychem.com CHINA 29865 58
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 29991 58
AFINE CHEMICALS LIMITED
008657185134551
008657185134895 info@afinechem.com CHINA 15559 58
Baoji Guokang Healthchem co.,ltd
09178656283
cngksw@aliyun.com CHINA 9482 58

View Lastest Price from POLYDIMETHYLSILOXANE manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-14 Simethicone
8050-81-5
US $150.00 / ASSAYS 10g >99% 500kg/month HEBEI YINGONG NEW MATERIAL TECHNOLOGY CO.,LTD
2019-12-31 POLYDIMETHYLSILOXANE
8050-81-5
US $1.00 / g 1g 99% 200kg Career Henan Chemical Co

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