ChemicalBook >> CAS DataBase List >>POLYDIMETHYLSILOXANE


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Last updated:2023-11-09 17:14:14


Density 1 g/mL at 20 °C
vapor pressure 5 mm Hg ( 20 °C)
refractive index n20/D 1.406
Flash point >101°C
storage temp. room temp
solubility Practically insoluble in water, very slightly soluble or practically insoluble in anhydrous ethanol, practically insoluble in methanol, partly miscible with ethyl acetate, with methylene chloride, with methyl ethyl ketone and with toluene.
form emulsion
color Colorless
LogP 3.404 (est)
EPA Substance Registry System Simethicone (8050-81-5)


Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
Signal word  Warning
Hazard statements  H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xn,Xi
Risk Statements  36/37-20-62
Safety Statements  26-36-23-36/37
WGK Germany  3
RTECS  TQ2690000
HS Code  3910000000


Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A8011 Antifoam C Emulsion aqueous-silicone emulsion 8050-81-5 250ml $109 2023-06-20 Buy
Sigma-Aldrich A5757 Antifoam B Emulsion aqueous-silicone emulsion 8050-81-5 250ML $55.7 2023-06-20 Buy
Sigma-Aldrich A6582 Antifoam A concentrate active silicone polymer 100% 8050-81-5 100g $87.1 2023-06-20 Buy
Sigma-Aldrich A5757 Antifoam B Emulsion aqueous-silicone emulsion 8050-81-5 500ML $96.4 2023-06-20 Buy
Sigma-Aldrich A5633 Antifoam A Concentrate active silicone polymer 100?% 8050-81-5 25G $60 2023-06-20 Buy
Product number Packaging Price Buy
A8011 250ml $109 Buy
A5757 250ML $55.7 Buy
A6582 100g $87.1 Buy
A5757 500ML $96.4 Buy
A5633 25G $60 Buy

POLYDIMETHYLSILOXANE Chemical Properties,Uses,Production

Chemical Properties

Viscous, greyish-white, opalescent liquid.

Chemical Properties

The PhEur 6.0 and USP 32 describe simethicone as a mixture of fully methylated linear siloxane polymers containing repeating units of the formula [–(CH3)2SiO–]n, stabilized with trimethylsiloxy endblocking units of the formula [(CH3)3 SiO–], and silicon dioxide. It contains not less than 90.5% and not more than 99.0% of the polydimethylsiloxane [–(CH3)2SiO–]n, and not less than 4.0% and not more than 7.0% of silicon dioxide. The PhEur 6.0 additionally states that the degree of polymerization is between 20–400.
Simethicone occurs as a translucent, gray-colored, viscous fluid. It has a molecular weight of 14 000–21 000.




Simethicone Emulsion USP is a water dilutable, non-ionic emulsion containing 30% Simethicone USP by weight. Highly stable over a broad pH range. Simethicones are used as anti foam agents in the manufacture of drugs. Their use in Pharmaceuticals is to comb


Antifoam A Concentrate has been used as a component of Luria Bertani culture medium for growth of BL21 (DE3) E. coli cells transformed with the plasmids. It has also been used as a constituent in the preparation of aerosol generation fluid.


Simethicone is an oral anti-foaming agent used to reduce bloating, discomfort and pain caused by excess gas in the stomach or intestinal tract. Simethicone is a mixture of polydimethylsiloxane and hydrated silica gel.

Production Methods

Silicon dioxide is initially rendered hydrophobic in one of a variety of proprietary processes specific to a particular manufacturer. It is then slowly mixed with the silicone fluids in a formulation. After mixing, the simethicone is milled to ensure uniformity.

Manufacturing Process

In a 5 liter three-necked flask, fitted with a reflux condenser, agitator and thermometer, were placed 1,393 g (9.41 mold) of redistilled (CH3)2Si(OEt)2 and 1,110 g (9.41 mols) of (CH3)3SiOEt. To this solution was added 254 g (14.11 mols) of water containing 7.5 g of NaOH (approximately 1 NaOH per 100 silicon atoms). This insured the formation of only straight chain polymers. The mixture was heated to 40°C and the temperature continued to rise for nearly an hour. After adding 50 cc (20% excess) more water, the mixture was refluxed for two hours and then allowed to stand overnight.
Alcohol was then distilled off, until the temperature reached 100°C. 1,706.6 g of distillate was collected. (Theory 1,430 g.) This alcohol was poured into four times its volume of water and an insoluble oil separated (457 g). The insoluble fraction was added back to the copolymer residue from the distillation and 555 cc of 20% hydrochloric acid was added. The acid mixture was refluxed for two hours, and the silicon oils were carefully washed with distilled water until neutral. The yield was 1,420 g. (Theory 1,409 g.)

brand name

Gas-X (Novartis); Mylanta Gas Relief (Johnson & Johnson-Merck Consumer); Mylicon Infant’s Drops (Johnson & Johnson-Merck Consumer); Sentry Simethicone (Witco); Sentry Simethicone Emulsion (Witco).

Therapeutic Function


General Description

Antifoam A Concentrate is an extremely effective foam suppressor for aqueous and non-aqueous systems. It is 100% active silicone polymer. No emulsifiers are present. Antifoam A Concentrate is typically effective at 1-100 ppm. Antifoam A Concentrate should be diluted with 3-10 parts of propylene glycol (aqueous) or vegetable oil (nonaqueous) with slow mixing. The product will be stable in the pH range of 5 to 9. Antifoam A Concentrate can be added directly to a fermentation medium, but it is not recommended that it be pumped to a fermenter on an as-needed basis.

Pharmaceutical Applications

The main use of simethicone as an excipient is as an antifoaming agent in pharmaceutical manufacturing processes, for which 1–50 ppm is used.
Therapeutically, simethicone is included in a number of oral pharmaceutical formulations as an antiflatulent, although its therapeutic benefit is questionable. It is also included in antacid products such as tablets or capsules. In some types of surgical or gastroscopic procedures where gas is used to inflate the body cavity, a defoaming preparation containing simethicone may be used in the area to control foaming of the fluids.
When simethicone is used in aqueous formulations, it should be emulsified to ensure compatibility with the aqueous system and components.
In the USA, up to 10 ppm of simethicone may be used in food products.


Simethicone is used in cosmetics, foods, and oral and topical pharmaceutical formulations, and is generally regarded as a relatively nontoxic and nonirritant material when used as an excipient. Direct contact with the eye may cause irritation.
Therapeutically, oral doses of 125–250mg of simethicone, three or four times daily, have been given as an antiflatulent. Doses of 20–40 mg of simethicone have been given with feeds to relieve colic in infants.
LD50 (dog, IV): 0.9 g/kg


Simethicone is generally regarded as a stable material when stored in the original unopened container. A shelf-life of 18 months from the date of manufacture is typical. However, some simethicone products have a tendency for the silicon dioxide to settle slightly and containers of simethicone should therefore be shaken thoroughly to ensure uniformity of contents before sampling or use. Simethicone should be stored in a cool, dry, location away from oxidizing materials.
Simethicone can be sterilized by dry heating or autoclaving. With dry heating, a minimum of 4 hours at 160℃ is required.


Simethicone as supplied is not generally compatible with aqueous systems and will float like an oil on a formulation unless it is first emulsified. It should not be used in formulations or processing conditions that are very acidic (below pH 3) or highly alkaline (above pH 10), since these conditions may have some tendency to break the polydimethylsiloxane polymer. Simethicone cannot normally be mixed with polar solvents of any kind because it is very minimally soluble. Simethicone is incompatible with oxidizing agents.

Regulatory Status

GRAS listed. Included in the FDA Inactive Ingredients Database (oral emulsions, powders, solutions, suspensions, tablets; and rectal and topical preparations). Included in nonparenteral medicines licensed in the UK.

POLYDIMETHYLSILOXANE Preparation Products And Raw materials

Global( 282)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Chinqesen Biotechnology Co., Ltd.
+86-16628886292 +86-19521323435 China 253 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177 China 5921 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 China 21708 55
Hubei Jusheng Technology Co.,Ltd.
18871490254 CHINA 28180 58
Hubei xin bonus chemical co. LTD
86-13657291602 CHINA 22968 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 China 39916 58
career henan chemical co
+86-0371-86658258 15093356674; China 29827 58
Hebei Mojin Biotechnology Co., Ltd
15028179902 +8615028179902 China 12384 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 United States 19894 58
Hubei Ipure Biology Co., Ltd
+8613367258412 China 10326 58

View Lastest Price from POLYDIMETHYLSILOXANE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
US $30.00-20.00 / BOX 10BOX 99 20TONS Shanghai Chinqesen Biotechnology Co., Ltd.
US $0.00 / kg 1kg 0.99 20tons Hebei Yanxi Chemical Co., Ltd.
Simethicone pictures 2023-06-26 Simethicone
US $150.00 / ASSAYS 10g >99% 500kg/month Hebei Mingeng Biotechnology Co., Ltd
  • Simethicone pictures
  • Simethicone
  • US $150.00 / ASSAYS
  • >99%
  • Hebei Mingeng Biotechnology Co., Ltd
α-(Trimethylsilyl)-ω-methylpoly[oxy(dimethylsilylene)] mixture with silicon dioxide Viscosity standard, Nominally 50cSt at 40 and 7.3cSt at 100 Viscosity standard, Nominally 120cSt at 40 and 20cSt at 100 Viscosity standard, Nominally 100cSt at 40°C and 16.8cSt at 100°C Viscosity standard, Nominally 10cSt at 40 and 2.7cSt at 100 Viscosity standard, Nominally 360cSt at 40°C and 42cSt at 100°C Viscosity standard, Nominally 30cSt at 40°C and 5.3cSt at 100°C Viscosity standard, Nominally 500cSt at 40 and 52cSt at 100 Viscosity standard, Nominally 930cSt at 40 and 82cSt at 100 DCantifoamA EIGHT-ARM POLY(DIMETHYL SILOXANE) DOW CORNING 1500 ANTIFOAM DOW CORNING 1510 ANTIFOAM DOW CORNING 1520EU ANTIFOAM DOW CORNING 346 EMULSION SINGLE RELEASE AGENT DOW CORNING ANTIFOAM MSA COMPOUND DOW CORNING ANTIFOAM RD EMULSION DOW CORNING DB-110A EU ANTIFOAM EMULSION DOW CORNING DB-310 ANTIFOAM EMULSION EXTREME LOW VOLATILITY POLYDIMETHYLSILOXANE ANTIFOAM A ANTIFOAM A EMULSION ANTIFOAM AF(TM) POLY(DIMETHYLSILOXANE), METHYL TERMINATED SIMETHICONE USP LIQUID Simethicone,Usp Aligest Plus Dow AntifoaM A Dow Corning AntifoaM A Q 7-2587 SilfoaM SE 2 SiMiticone HSDB 3906 Mylicon Infant's Drops Sab SiMplex Sentry SiMethicone EMulsion SIMETHICONE 30%,50% & 100% ANTIFOAM A(TM) ANTIFOAM B(R) SILICONE EMULSION ANTIFOAM B SILICONE ANTIFOAM EMULSION RD REDUCED VOLATILITY POLYDIMETHYLSILOXANE SILICONE ANTI-FOAM EMULSION POLYDIMETHYLSILOXANE 158'000 POLYDIMETHYLSILOXANE 16'000 POLYDIMETHYLSILOXANE 173'000 POLYDIMETHYLSILOXANE 1'850 POLYDIMETHYLSILOXANE 197'000 POLYDIMETHYLSILOXANE 25'800 POLYDIMETHYLSILOXANE 303'000 POLYDIMETHYLSILOXANE 311 POLYDIMETHYLSILOXANE 3'320 POLYDIMETHYLSILOXANE 47'500 POLYDIMETHYLSILOXANE 7'100 POLYDIMETHYLSILOXANE 71'000 POLYDIMETHYLSILOXANE 89'800 POLYDIMETHYLSILOXANE GUM Mixture with silicon dioxide