EPIDERMAL GROWTH FACTOR RECEPTOR
- CAS No.
- Chemical Name:
- EPIDERMAL GROWTH FACTOR RECEPTOR
- Synonyms
- Wa5;mENA;ERRP;ERBB;EGF-R;EGF RECEPTOR;EGFR active mouse;EPIDERMAL GROWTH FACTOR RECEPTOR;EGFR (L861Q), active, GST tagged human;EGFR (695-end), active, GST tagged human
- CBNumber:
- CB6750707
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD01634808
- MOL File:
- Mol file
| storage temp. | -70°C |
|---|---|
| form | lyophilized powder |
| NCI Dictionary of Cancer Terms | epidermal growth factor receptor |
| FDA UNII | RO03J093CP |
SAFETY
Risk and Safety Statements
| Hazard Codes | B |
|---|---|
| WGK Germany | 3 |
EPIDERMAL GROWTH FACTOR RECEPTOR price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SRP5023 | EGFR (695-end), active, GST tagged human PRECISIO? Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution | 10μG | $523 | 2023-06-20 | Buy | |
| Usbiological | E3374-17C | Epidermal Growth Factor Receptor | 1mg | $531 | 2021-12-16 | Buy | |
| Usbiological | 138540 | EGF Receptor | 20ug | $353 | 2021-12-16 | Buy | |
| Usbiological | E3375-21 | Epidermal Growth Factor Receptor | 100ug | $585 | 2021-12-16 | Buy | |
| Usbiological | 355459 | Epidermal Growth Factor Receptor | 48Tests | $588 | 2021-12-16 | Buy |
EPIDERMAL GROWTH FACTOR RECEPTOR Chemical Properties,Uses,Production
Description
EGFR (HER1, ErbB1) is an RTK expressed on the surface of cells of mesodermal and ectodermal origin, and it mediates cell growth, proliferation, and differentiation in numerous organs [16, 17]. EGFR belongs to the ErbB family of RTKs, which also includes HER2 (ErbB2), HER3 (ErbB3), and HER4 (ErbB4). EGFR binds at least seven highly variable growth factor ligands [18]. Upon stimulation, EGFR undergoes combinatorial homo- or hetero-dimerization with one of the proteins of the HER family, thereby activating an expansive signaling network [16, 19, 20]. The EGFR transmembrane protein has a large extracellular component (with 4 domains, ~620 amino acids) that primarily serves as ligand-binding sites and which is anchored by a short helical transmembrane domain to the intracellular tyrosine kinase domain (TKD) (Fig.?1) [18].
Mechanism of action
EGFR is believed to play a role in the pathogenesis of lung cancer and is overexpressed in a majority of NSCLCs [21, 22]. However, the clinical importance of EGFR expression in the general NSCLC population is unclear. There was some suggestion that EGFR expression may serve as a predictive biomarker [21], but this has been superseded by mutational analysis after the identification of actionable driver mutations in the EGFR gene.
EPIDERMAL GROWTH FACTOR RECEPTOR Preparation Products And Raw materials
Raw materials
Preparation Products
EPIDERMAL GROWTH FACTOR RECEPTOR Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Supplier | Advantage |
|---|---|
| Sigma-Aldrich | 80 |