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1H-Benzimidazole-6-carboxamide, 1-ethyl-2-(hydroxydiphenylmethyl)-N-[(2R)-2-hydroxypropyl]-

1H-Benzimidazole-6-carboxamide, 1-ethyl-2-(hydroxydiphenylmethyl)-N-[(2R)-2-hydroxypropyl]- structure

CAS No.: 1824637-41-3

Chemical Name:: 1H-Benzimidazole-6-carboxamide, 1-ethyl-2-(hydroxydiphenylmethyl)-N-[(2R)-2-hydroxypropyl]-

Synonyms: orally active,VY3135,Inhibitor,inhibit,VY 3 135,breast cancer,stable ACSS2 inhibitor;3-ethyl-2-[hydroxy(diphenyl)methyl]-N-[(2R)-2-hydroxypropyl]-5-benzimidazolecarboxamide;1H-Benzimidazole-6-carboxamide, 1-ethyl-2-(hydroxydiphenylmethyl)-N-[(2R)-2-hydroxypropyl]-

CBNumber:: CB710673622

Molecular Formula:: C26H27N3O3

Molecular Weight:: 429.51

MDL Number:

MOL File:: 1824637-41-3.mol

Last updated:2023-05-21 10:59:17

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1H-Benzimidazole-6-carboxamide, 1-ethyl-2-(hydroxydiphenylmethyl)-N-[(2R)-2-hydroxypropyl]- Properties

Boiling point	742.8±60.0 °C(Predicted)
Density	1.21±0.1 g/cm3(Predicted)
storage temp.	4°C, protect from light
solubility	DMSO : 100 mg/mL (232.82 mM; Need ultrasonic)
pka	12.08±0.29(Predicted)

1H-Benzimidazole-6-carboxamide, 1-ethyl-2-(hydroxydiphenylmethyl)-N-[(2R)-2-hydroxypropyl]- Chemical Properties,Uses,Production

Biological Activity

VY-3-135 is a potent, orally active, and stable ACSS2 inhibitor with an IC50 value of 44 nM. VY-3-135 is specific to ACSS2 among the AcCoA synthetase family of enzymes. VY-3-135 does not inhibit ACSS1 or ACSS3 enzymatic activity. VY-3-135 can be used for the research of breast cancer[1]. VY-3-135 (0.1, 1 μM; for 24 hours) blocks acetate dependent labeling of palmitate by 13C2-acetate in ACSS2low A7C11 and ACSS2high Brpkp110 cells[1]. VY-3-135 (100 mg/kg/day; PO; 30 days) represses MDA-MB-468 (ACSS2high) tumor growth but is mostly ineffective at blocking WHIM12 (ACSS2low) growth[1].

References

[1]. Katelyn D Miller, et al. Targeting ACSS2 with a Transition-State Mimetic Inhibits Triple-Negative Breast Cancer Growth. Cancer Res. 2021 Mar 1;81(5):1252-1264.

1H-Benzimidazole-6-carboxamide, 1-ethyl-2-(hydroxydiphenylmethyl)-N-[(2R)-2-hydroxypropyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Benzimidazole-6-carboxamide, 1-ethyl-2-(hydroxydiphenylmethyl)-N-[(2R)-2-hydroxypropyl]- Suppliers

Global( 17)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Chemtour Biotech Co., Ltd	+8617327281506	market@chemtour.com	China	1472	58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd	+8618235132063	sales@tihondan.com	China	3719	58
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8011	62
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9445	58
SuZhou Medinoah Co.,LTD.	0512-0512-69561983 13914027025	he_qf@medinoah.com	China	3380	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9414	58
Shandong Jirun Biomedical Technology Co., Ltd.	0539-0539-8613587 17661611089	2639273505@qq.com	China	161	58
InvivoChem	13549236410	sales@invivochem.cn	China	6712	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
Chemtour Biotech Co., Ltd	58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd	58
ShangHai Biochempartner Co.,Ltd	62
Shanghai Chaolan Chemical Technology Center	58
SuZhou Medinoah Co.,LTD.	58
DC Chemicals	58
Shandong Jirun Biomedical Technology Co., Ltd.	58
InvivoChem	58

1H-Benzimidazole-6-carboxamide, 1-ethyl-2-(hydroxydiphenylmethyl)-N-[(2R)-2-hydroxypropyl]- orally active,VY3135,Inhibitor,inhibit,VY 3 135,breast cancer,stable ACSS2 inhibitor 3-ethyl-2-[hydroxy(diphenyl)methyl]-N-[(2R)-2-hydroxypropyl]-5-benzimidazolecarboxamide 1824637-41-3