Cagrilintide
- CAS No.
- 1415456-99-3
- Chemical Name:
- Cagrilintide
- Synonyms
- Caglitide;Cargliptin;Cagrilintide;Cagrilintide acetate
- CBNumber:
- CB712152538
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
| FDA UNII | AO43BIF1U8 |
|---|
Cagrilintide Chemical Properties,Uses,Production
Description
Cagrilintide is an amylin-analog, now being developed in combination with the GLP-1 agonist semaglutide to achieve sustained weight loss in persons with overweight and obesity. This drug is an investigational therapy that reduced body weight in a phase 2 trial when administered as monotherapy in participants without diabetes and with a BMI of at least 30 kg/m2 or at least 27 kg/m2 with hypertension or dyslipidaemia[1-2].
Mechanism of action
Cagrilintide, a non-selective agonist, is designed for weekly subcutaneous injection at low pH. It is based on the h-amylin backbone, drawing inspiration from calcitonin, and exhibits a prolonged action profile, likely attributed to reversible albumin binding similar to semaglutide. This amylin analog is currently under development in combination with the GLP-1 agonist semaglutide to achieve sustained weight loss in individuals with overweight and obesity. Amylin, co-secreted with insulin from pancreatic beta cells, exerts its satiating effect through both the homoeostatic and hedonic brain regions. On the other hand, semaglutide, a GLP-1 receptor agonist, reduces appetite by acting on GLP-1 receptors in the hypothalamus, increases insulin production, and decreases glucagon secretion, thus delaying gastric emptying. These distinct yet interconnected mechanisms of action of an amylin analog and a GLP-1 receptor agonist appear to synergistically reduce appetite[3-4].
References
[1] Antonella M D’Ascanio, William H Frishman, & Jamie A Mullally. “Cagrilintide: A Long-Acting Amylin Analog for the Treatment of Obesity.” Cardiology in Review (2024): 83–90.
[2] Juan P Frias. “Efficacy and safety of co-administered once-weekly cagrilintide 2·4 mg with once-weekly semaglutide 2·4 mg in type 2 diabetes: a multicentre, randomised, double-blind, active-controlled, phase 2 trial.” Lancet 402 10403 (2023): 720–730.
[3] Antonella M D’Ascanio, William H Frishman, Jamie A Mullally. “Cagrilintide: A Long-Acting Amylin Analog for the Treatment of Obesity.” Cardiology in Review (2024): 83–90.
[4] Thomas Kruse*. “Development of Cagrilintide, a Long-Acting Amylin Analogue.” Journal of Medicinal Chemistry 64 15 (2021): 11183–11194.
Cagrilintide Preparation Products And Raw materials
Raw materials
Preparation Products
Cagrilintide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan Tai Hui Biotechnology Co., Ltd | +86-18224031330 +86-18081096520 | 404435307@qq.com | China | 23 | 58 |
| Henan Tengmao Chemical Technology Co. LTD | +8615238638457 | salesvip2@hntmhg.com | China | 415 | 58 |
| Hebei Lingding Biotechnology Co., Ltd. | +86-18031140164 +86-19933155420 | erin@hbldbiotech.com | China | 878 | 58 |
| Zhejiang Hangyu API Co., Ltd | +8617531972939 | anna@api-made.com | China | 2944 | 58 |
| Dorne Chemical Technology co. LTD | +86-13583358881 +86-18560316533 | Ethan@dornechem.com | China | 294 | 58 |
| ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD | +8619155187336 | shengzhikai3@shengzhikai.com | China | 38 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Hebei Kangcang new material Technology Co., LTD | +8615713292910 | Nancy@kangcang.com.cn | China | 340 | 58 |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 951 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10248 | 58 |
View Lastest Price from Cagrilintide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-05-02 | Cagrilintide
1415456-99-3
|
US $1.00 / g | 1g | 99% | 100kg | Dorne Chemical Technology co. LTD | |
 |
2024-04-30 | Cagrilintide
1415456-99-3
|
US $120.00-70.00 / box | 1box | 99% | 5000box | hebei hongtan Biotechnology Co., Ltd | |
 |
2024-04-30 | Cagrilintide
1415456-99-3
|
US $100.00 / kg | 1kg | 98% | 20ton | Hebei Kangcang new material Technology Co., LTD |
-
- Cagrilintide
1415456-99-3
- US $1.00 / g
- 99%
- Dorne Chemical Technology co. LTD
-
- Cagrilintide
1415456-99-3
- US $120.00-70.00 / box
- 99%
- hebei hongtan Biotechnology Co., Ltd
-
- Cagrilintide
1415456-99-3
- US $100.00 / kg
- 98%
- Hebei Kangcang new material Technology Co., LTD