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ChemicalBook >> CAS DataBase List >>5H-Pyrido[3,2-b]indole-7-carbonitrile, 4-[(1-methylethyl)amino]-3-[1-(4-piperidinyl)-1H-1,2,3-triazol-4-yl]-

5H-Pyrido[3,2-b]indole-7-carbonitrile, 4-[(1-methylethyl)amino]-3-[1-(4-piperidinyl)-1H-1,2,3-triazol-4-yl]-

5H-Pyrido[3,2-b]indole-7-carbonitrile, 4-[(1-methylethyl)amino]-3-[1-(4-piperidinyl)-1H-1,2,3-triazol-4-yl]- Structure
5H-Pyrido[3,2-b]indole-7-carbonitrile, 4-[(1-methylethyl)amino]-3-[1-(4-piperidinyl)-1H-1,2,3-triazol-4-yl]- structure
CAS No.
2681278-09-9
Chemical Name:
5H-Pyrido[3,2-b]indole-7-carbonitrile, 4-[(1-methylethyl)amino]-3-[1-(4-piperidinyl)-1H-1,2,3-triazol-4-yl]-
Synonyms
IRAK4-IN-10;5H-Pyrido[3,2-b]indole-7-carbonitrile, 4-[(1-methylethyl)amino]-3-[1-(4-piperidinyl)-1H-1,2,3-triazol-4-yl]-
CBNumber:
CB712596822
Molecular Formula:
C22H24N8
Molecular Weight:
400.48
MDL Number:
MOL File:
2681278-09-9.mol
Last updated:2025-10-29 15:43:00
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5H-Pyrido[3,2-b]indole-7-carbonitrile, 4-[(1-methylethyl)amino]-3-[1-(4-piperidinyl)-1H-1,2,3-triazol-4-yl]- Properties

Boiling point 726.9±70.0 °C(Predicted)
Density 1.44±0.1 g/cm3(Predicted)
pka 14.03±0.40(Predicted)

5H-Pyrido[3,2-b]indole-7-carbonitrile, 4-[(1-methylethyl)amino]-3-[1-(4-piperidinyl)-1H-1,2,3-triazol-4-yl]- Chemical Properties,Uses,Production

Uses

IRAK4-IN-10 (compound 75) is a potent IRAK4 inhibitor with an IC50 of 1.5 nM. IRAK4-IN-10 blocks MyD88 dependent signaling. IRAK4-IN-9 has the potential for the research of inflammatory diseases, autoimmune diseases, and cancer[1].

IC 50

IRAK4: 1.5 nM (IC50)

References

[1] Sabnis RW. Novel Tricyclic Heteroaryl Compounds as IRAK4 Inhibitors for Treating Cancer, Autoimmune and Inflammatory Diseases. ACS Med Chem Lett. 2022 Feb 28;13(3):336-337. DOI:10.1021/acsmedchemlett.2c00060

5H-Pyrido[3,2-b]indole-7-carbonitrile, 4-[(1-methylethyl)amino]-3-[1-(4-piperidinyl)-1H-1,2,3-triazol-4-yl]- Preparation Products And Raw materials

Raw materials

Preparation Products

5H-Pyrido[3,2-b]indole-7-carbonitrile, 4-[(1-methylethyl)amino]-3-[1-(4-piperidinyl)-1H-1,2,3-triazol-4-yl]- Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32435 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29641 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58

View Lastest Price from 5H-Pyrido[3,2-b]indole-7-carbonitrile, 4-[(1-methylethyl)amino]-3-[1-(4-piperidinyl)-1H-1,2,3-triazol-4-yl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
IRAK4-IN-10 pictures 2025-08-29 IRAK4-IN-10
2681278-09-9
 US $633.00 / mg 99.76% 10g TargetMol Chemicals Inc.
  • IRAK4-IN-10 pictures
  • IRAK4-IN-10
    2681278-09-9
  • US $633.00 / mg
  • 99.76%
  • TargetMol Chemicals Inc.

5H-Pyrido[3,2-b]indole-7-carbonitrile, 4-[(1-methylethyl)amino]-3-[1-(4-piperidinyl)-1H-1,2,3-triazol-4-yl]- Spectrum

5H-Pyrido[3,2-b]indole-7-carbonitrile, 4-[(1-methylethyl)amino]-3-[1-(4-piperidinyl)-1H-1,2,3-triazol-4-yl]-(2681278-09-9)1HNMR
5H-Pyrido[3,2-b]indole-7-carbonitrile, 4-[(1-methylethyl)amino]-3-[1-(4-piperidinyl)-1H-1,2,3-triazol-4-yl]- IRAK4-IN-10 2681278-09-9