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bottromycin A(2)

bottromycin A(2) structure

CAS No.: 15005-62-6

Chemical Name:: bottromycin A(2)

Synonyms: bottromycin A(2);b-Alanine, N-[(2S)-2-[[glycyl-(3R)-3-methyl-Lprolyl-L-valyl]amino]-1-imino-3,3-dimethylbutyl]-3-methyl-L-valyl-(bS)-b-methyl-L-phenylalanyl-3-(2-thiazolyl)-, methyl ester, cyclic (1')-imine,(3R)-;β-Alanine, N-[(2S)-2-[[glycyl-(3R)-3-methyl-L-prolyl-L-valyl]amino]-1-imino-3,3-dimethylbutyl]-3-methyl-L-valyl-(βS)-β-methyl-L-phenylalanyl-3-(2-thiazolyl)-, methyl ester, cyclic (1→1')-imine, (3R)-

CBNumber:: CB71399096

Molecular Formula:: C42H62N8O7S

Molecular Weight:: 823.07

MDL Number:: MFCD34166124

MOL File:: 15005-62-6.mol

Last updated:2023-05-21 10:59:17

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bottromycin A(2) Properties

Boiling point	1061.3±65.0 °C(Predicted)
Density	1.28±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	Ether: soluble,Methanol: soluble,
form	A solid
pka	12.18±0.46(Predicted)
Water Solubility	Water: soluble

bottromycin A(2) Chemical Properties,Uses,Production

Biological Activity

Bottromycin A2 is an antibiotic originally isolated from Streptomyces.1 It blocks the binding of aminoacyl-tRNA to the A site of the 50S ribosome, inhibiting protein synthesis.2 Bottromycin A2 is active against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci with MIC values of 1 and 0.5 μg/ml, respectively.

References

1.Nakamura, S., Yajima, T., Lin, Y., et al.Isolation and characterization of bottromycins A2, B2, C2J. Antibiot. (Tokyo)20(1)1-5(1967) 2.Gouda, H., Kobayashi, Y., Yamada, T., et al.Three-dimensional solution structure of bottromycin A2: A potent antibiotic active against methicillin-resistant Staphylococcus aureus and vancomycin-resistant EnterococciChem. Pharm. Bull. (Tokyo)60(2)169-171(2012)

bottromycin A(2) Preparation Products And Raw materials

Raw materials

Preparation Products

bottromycin A(2) Suppliers

Global( 7)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	+16314854226	inquiry@bocsci.com	United States	19743	58
Nanjing Peptide Biotech Ltd.	025-58361106-805 13082558573	liugang@njpeptide.com	China	9961	55
Changzhou Furuisi Biotechnology Co., Ltd	0519-85524369	3477467573@qq.com	China	8618	58
ChemeGen 中国	18818260767	sales@chemegen.com	China	6975	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	8740	58

Supplier	Advantage
BOC Sciences	58
Nanjing Peptide Biotech Ltd.	55
Changzhou Furuisi Biotechnology Co., Ltd	58
ChemeGen 中国	58
Shanghai Yifei Biotechnology Co. , Ltd.	58

bottromycin A(2) b-Alanine, N-[(2S)-2-[[glycyl-(3R)-3-methyl-Lprolyl-L-valyl]amino]-1-imino-3,3-dimethylbutyl]-3-methyl-L-valyl-(bS)-b-methyl-L-phenylalanyl-3-(2-thiazolyl)-, methyl ester, cyclic (1')-imine,(3R)- β-Alanine, N-[(2S)-2-[[glycyl-(3R)-3-methyl-L-prolyl-L-valyl]amino]-1-imino-3,3-dimethylbutyl]-3-methyl-L-valyl-(βS)-β-methyl-L-phenylalanyl-3-(2-thiazolyl)-, methyl ester, cyclic (1→1')-imine, (3R)- 15005-62-6 C42H62N8O7S