ANTI-EPITHELIAL MEMBRANE ANTIGEN
- CAS No.
- Chemical Name:
- ANTI-EPITHELIAL MEMBRANE ANTIGEN
- Synonyms
- ANTI-EMA;MS X ANTI-EMA;ANTI-MS X EMA;ANTI-HUMAN EMA;ANTI-EPISIALIN;ANTI-EMA, HUMAN;ANTI-EPISIALIN (EMA);ANTI-HUMAN EPISIALIN;ANTI-MEMBRANE ANTIGEN;ANTI-EPITHELIAL MEMBRANE ANTIGEN
- CBNumber:
- CB7157325
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD00211919
- MOL File:
- Mol file
ANTI-EPITHELIAL MEMBRANE ANTIGEN price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E0143 | Monoclonal Anti-Episialin (EMA) antibody produced in mouse clone GP1.4, ascites fluid | 0.2mL | $398 | 2023-01-07 | Buy | |
| American Custom Chemicals Corporation | ATB0011533 | ANTI-EPITHELIAL MEMBRANE ANTIGEN-HUMAN 95.00% | 5MG | $498.53 | 2021-12-16 | Buy |
ANTI-EPITHELIAL MEMBRANE ANTIGEN Chemical Properties,Uses,Production
Uses
Cell-membrane-associated, mucin-like molecules, such as episialin has a protective function against toxic substances. Data on the effect of episialin on the adhesion properties of cultured cells suggests that episialin expressed at high levels on cells may have a major function in reducing the aggregation capacity of these cells, thus influencing the adherence to various extracellular matrix components by masking adhesion molecules.
General Description
Monoclonal Anti-Episialin (EMA) (mouse IgG1 isotype) is derived from the GP1.4 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.
Biochem/physiol Actions
Episialin is a transmembrane, high molecular weight, mucin-like glycoprotein (apparent molecular weight of 265-400 kDa) containing many carbohydrate side chains, that are predominantly attached to the molecule by O-glycosidic linkages. It is known as epithelial membrane antigen (EMA), MUC1 and polymorphic epithelial mucin (PEM). The episialin molecule is transmembranous with a relatively large extracellular domain and a cytoplasmic domain of 69 amino acids. The extracellular domain consists mainly of a region of nearly identical repeats of 20 amino acids, the number of which can vary between about 30 and 90 because of genetic polymorphism. The episialin molecule is synthesized as one large precursor containing only N-linked glycans and is immediately proteolytically cleaved while still in the endoplasmic reticulum.
ANTI-EPITHELIAL MEMBRANE ANTIGEN Preparation Products And Raw materials
Raw materials
Preparation Products
ANTI-EPITHELIAL MEMBRANE ANTIGEN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Riedel-de Haen AG | -- | United States | 6825 | 87 | |
| SIGMA-RBI | -- | Switzerland | 6913 | 91 | |
| BIOTREND Chemikalien GmbH | -- | jaeger@biotrend.com | Germany | 6115 | 76 |
| Zymed Laboratories Inc. | -- | United States | 3068 | 86 | |
| MP Biomedicals, Inc. | -- | United States | 6566 | 81 | |
| BIODESIGN International/OEM Concepts | -- | info@biodesign.com | United States | 2376 | 50 |
| Beckman Coulter, Inc. | -- | United States | 1183 | 86 | |
| Vision BioSystems | -- | sales.usa@vision-bio.com | United States | 542 | 74 |
| Cortex Biochem, Inc. | -- | info@cortex-biochem.com | United States | 1557 | 77 |
| Chemicon Internatinal, Inc. | -- | custserv@chemicon.com | United States | 4175 | 65 |
| Supplier | Advantage |
|---|---|
| Riedel-de Haen AG | 87 |
| SIGMA-RBI | 91 |
| BIOTREND Chemikalien GmbH | 76 |
| Zymed Laboratories Inc. | 86 |
| MP Biomedicals, Inc. | 81 |
| BIODESIGN International/OEM Concepts | 50 |
| Beckman Coulter, Inc. | 86 |
| Vision BioSystems | 74 |
| Cortex Biochem, Inc. | 77 |
| Chemicon Internatinal, Inc. | 65 |