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Dibutyl phthalate

Dibutyl phthalate
Dibutyl phthalate structure
CAS No.
84-74-2
Chemical Name:
Dibutyl phthalate
Synonyms
DBP;Bufa;Elaol;px104;NLA-10;PX 104;DBP(R);NSC 6370;hatcoldbp;n-dibutyl
CBNumber:
CB7161937
Molecular Formula:
C16H22O4
Formula Weight:
278.34
MOL File:
84-74-2.mol

Dibutyl phthalate Properties

Melting point:
-35 °C
Boiling point:
340 °C(lit.)
Density 
1.043 g/mL at 25 °C(lit.)
vapor density 
9.6 (vs air)
vapor pressure 
1 mm Hg ( 147 °C)
refractive index 
n20/D 1.492(lit.)
Flash point:
340 °F
storage temp. 
2-8°C
solubility 
Very soluble in alcohol, ether, acetone, benzene
form 
Liquid
Specific Gravity
1.049 (20/20℃)
color 
APHA: ≤10
Relative polarity
0.272
explosive limit
0.47%, 236°F
Water Solubility 
Slightly soluble. 0.0013 g/100 mL
FreezingPoint 
-35℃
Merck 
14,3035
BRN 
1914064
Exposure limits
NIOSH REL: TWA 5 mg/m3, IDLH 4,000 mg/m3; OSHA PEL: TWA 5 mg/m3; ACGIH TLV: TWA 5 mg/m3.
InChIKey
DOIRQSBPFJWKBE-UHFFFAOYSA-N
CAS DataBase Reference
84-74-2(CAS DataBase Reference)
NIST Chemistry Reference
Dibutyl phthalate(84-74-2)
EPA Substance Registry System
1,2-Benzenedicarboxylic acid, dibutyl ester(84-74-2)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
  • NFPA
Hazard Codes  T,N,F
Risk Statements  61-50-62-39/23/24/25-23/24/25-11
Safety Statements  53-45-61-36/37-16
RIDADR  UN 3082 9/PG 3
WGK Germany  2
RTECS  TI0875000
Autoignition Temperature 756 °F
TSCA  Yes
HazardClass  9
PackingGroup  III
HS Code  29173100
Hazardous Substances Data 84-74-2(Hazardous Substances Data)
Toxicity Acute oral LD50 for rats 8,000 mg/kg (RTECS, 1985).
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warning P264, P305+P351+P338,P337+P313
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger P260, P264, P270, P314, P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning P273, P391, P501
H412 Harmful to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 3 P273, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P272 Contaminated work clothing should not be allowed out of the workplace.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P391 Collect spillage. Hazardous to the aquatic environment
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P307+P311 IF exposed: call a POISON CENTER or doctor/physician.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to..…

NFPA 704

Diamond Hazard Value Description
1
0 0
Health   0 Poses no health hazard, no precautions necessary and would offer no hazard beyond that of ordinary combustible materials
Flammability   1 Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia)
Instability   0 Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
Special  

(NFPA, 2010)

Dibutyl phthalate price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 18281 Dibutyl phthalate certified reference material, TraceCERT 84-74-2 50mg $79.8 2018-11-20 Buy
Sigma-Aldrich 1187080 Dibutyl Phthalate United States Pharmacopeia (USP) Reference Standard 84-74-2 200mg $386 2018-11-13 Buy
TCI Chemical P0292 Dibutyl Phthalate >97.0%(GC) 84-74-2 25mL $14 2018-11-22 Buy
TCI Chemical P0292 Dibutyl Phthalate >97.0%(GC) 84-74-2 500mL $16 2018-11-22 Buy
Alfa Aesar 031244 Di-n-butyl phthalate 99+% 84-74-2 5g $11.2 2018-11-20 Buy

Dibutyl phthalate Chemical Properties,Uses,Production

Chemical Properties

clear liquid

Chemical Properties

Dibutyl phthalate occurs as an odorless, oily, colorless, or very slightly yellow-colored, viscous liquid.

Uses

Insect repellent.

Uses

Plasticizer; solvent for oil-soluble dyes, insecticides and other organics; antifoam agent; textile fiber lubricant; fragrance fixative; insect repellent.

Uses

A phthalate metabolite with genotoxic effect.

Uses

Plasticizer

Definition

ChEBI: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol.

Production Methods

Dibutyl phthalate is produced from n-butanol and phthalic anhydride in an ester formation reaction.

General Description

Dibutyl phthalate is a colorless oily liquid. Dibutyl phthalate is insoluble in water. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. Since Dibutyl phthalate is a liquid Dibutyl phthalate can easily penetrate the soil and contaminate groundwater and nearby streams. Dibutyl phthalate is combustible though Dibutyl phthalate may take some effort to ignite. Dibutyl phthalate is used in paints and plastics and as a reaction media for chemical reactions.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Dibutyl phthalate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Avoid contact with strong oxidizing agents and strong bases. Will not polymerize. [USCG, 1999]. Can generate electrostatic charges. [Handling Chemicals Safely 1980. p. 250].

Health Hazard

The toxicity of this compound is very low. Inhumans, oral intake of dibutyl phthalate at adose level of 150 mg/kg may cause nausea,vomiting, dizziness, hallucination, distortedvision, lacrimation, and conjunctivitis withprompt recovery. It metabolizes to monobutylester and phthalic acid and is excreted in urine.The inhalation toxicity should be insignificantbecause of its negligible low vapor pressure[<0.1 torr at 20°C (68°F)]. However, expo sure to its mist or aerosol can cause irritationof eyes and mucous membranes
LD50 value, oral (mice): 5300 mg/kg.

Fire Hazard

Combustible.

Pharmaceutical Applications

Dibutyl phthalate is used in pharmaceutical formulations as a plasticizer in film-coatings. It has been evaluated as a pore-forming agent in novel delivery systems.It is also used extensively as a solvent, particularly in cosmetic formulations such as antiperspirants, hair shampoos, and hair sprays. In addition to a number of industrial applications, dibutyl phthalate is used as an insect repellent, although it is not as effective as dimethyl phthalate.

Contact allergens

It is mainly used as a nonreactive epoxy diluent.

Safety Profile

Moderately toxic by intraperitoneal and intravenous routes. Mildly toxic by ingestion. Human systemic eye effects by ingestion, hallucinations, dstorted perceptions, nausea or vomiting, and kidney, ureter, or bladder changes. Experimental teratogenic and reproductive effects. Mutation data reported. Combustible when exposed to heat or flame; can react with oxidizing materials. Violent reaction with Cl2. Incompatible with chlorine. To fight fire, use CO2, dry chemical. When heated to decomposition it emits acrid smoke and fumes. See also ESTERS, PHTHALIC ACID, and n BUTYL ALCOHOL.

Safety

Dibutyl phthalate is generally regarded as a relatively nontoxic material, although it has occasionally been reported to cause hypersensitivity reactions. It is widely used in topical cosmetic and some oral pharmaceutical formulations.
LD50 (mouse, IV): 0.72g/kg
LD50 (mouse, oral): 5.3g/kg
LD50 (rat, oral): 8.0g/kg
LD50 (rat, IP): 3.05mL/kg

Environmental Fate

Biological. Under aerobic conditions using a freshwater hydrosol, mono-n-butyl phthalate and phthalic acid were produced. Under anaerobic conditions, phthalic acid was not present (Verschueren, 1983). In anaerobic sludge, di-n-butyl phthalate degraded as follows: monobutyl phthalate to phthalic acid to protocatechuic acid followed by ring cleavage and mineralization (Shelton et al., 1984). Engelhardt et al. (1975) reported that a variety of microorganisms were capable of degrading of di-n-butyl phthalate and suggested the following degradation scheme: di-n-butyl phthalate to mono-n-butyl phthalate to phthalic acid to 3,4-dihydroxybenzoic acid and other unidentified products. Di-n-butyl phthalate was degraded to benzoic acid by tomato cell suspension cultures (Lycopericon lycopersicum) (Pogány et al., 1990).
In a static-culture-flask screening test, di-n-butyl phthalate showed significant biodegradation with rapid adaptation. The ester (5 and 10 mg/L) was statically incubated in the dark at 25°C with yeast extract and settled domestic wastewater inoculum. After 7 days, 100% biodegradation was achieved (Tabak et al., 1981).
Soil. Under aerobic conditions using a fresh-water hydrosol, mono-n-butyl phthalate and phthalic acid were produced. Under anaerobic conditions, however, phthalic acid was not formed (Verschueren, 1983).
Photolytic. An aqueous solution containing titanium dioxide and subjected to UV radiation (l >290 nm) produced hydroxyphthalates and dihydroxyphthalates as intermediates (Hustert and Moza, 1988).
Chemical/Physical. Pyrolysis of di-n-butyl phthalate in the presence of polyvinyl chloride at 600°C gave the following compounds: indene, methylindene, naphthalene, 1- methylnaphthalene, 2-methylnaphthalene, biphenyl, dimethylnaphthalene, acenaphthene, fluorene, methylacenaphthene, methylfluorene and six unidentified compounds (Bove and Dalven, 1984).
Under alkaline conditions, di-n-butyl phthalate will initially hydrolyze to n-butyl hydrogen phthalate and n-butanol. The monoester will undergo further hydrolysis forming o-phthalic acid and n-butanol (Kollig, 1993).

storage

Dibutyl phthalate should be stored in a well-closed container in a cool, dry, location. Containers may be hazardous when empty since they can contain product residues such as vapors and liquids.

Purification Methods

Wash DBP with H2O (to free it from alcohol), then dilute NaOH (to remove any butyl hydrogen phthalate or acid), aqueous NaHCO3 (charcoal), then distilled water. Dry it (CaCl2), distil it at 10torr or less, and store it in a desiccator over P2O5. [Beilstein 9 II 586, 9 III 4102, 9 IV 3175.]

Incompatibilities

Dibutyl phthalate reacts violently with chlorine. It also reacts with oxidizing agents, acids, bases, and nitrates.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral capsules, delayed action, enteric coated, and controlled release tablets). Included in nonparenteral medicines licensed in the UK (oral capsules, tablets, granules; topical creams and solutions).

Dibutyl phthalate Preparation Products And Raw materials

Raw materials

Preparation Products


Dibutyl phthalate Suppliers

Global( 336)Suppliers
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View Lastest Price from Dibutyl phthalate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-23 Dibutyl phthalate
84-74-2
US $1.00 / kg 1kg 95%-99% as request career henan chemical co
2018-11-06 China manufacturer best price dibutyl phthalate
84-74-2
US $1.00 / KG 1KG 99% 20tons Hebei Chisure Biotechnology Co., Ltd.

Dibutyl phthalate Spectrum


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