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Dibutyl phthalate

Dibutyl phthalate
Dibutyl phthalate structure
CAS No.
84-74-2
Chemical Name:
Dibutyl phthalate
Synonyms
DBP;Bufa;Elaol;px104;NLA-10;PX 104;DBP(R);NSC 6370;XW-ZS-01;hatcoldbp
CBNumber:
CB7161937
Molecular Formula:
C16H22O4
Formula Weight:
278.34
MOL File:
84-74-2.mol

Dibutyl phthalate Properties

Melting point:
-35 °C (lit.)
Boiling point:
340 °C (lit.)
Density 
1.043 g/mL at 25 °C (lit.)
vapor density 
9.6 (vs air)
vapor pressure 
1 mm Hg ( 147 °C)
refractive index 
n20/D 1.492(lit.)
Flash point:
340 °F
storage temp. 
2-8°C
solubility 
Very soluble in alcohol, ether, acetone, benzene
form 
Liquid
Specific Gravity
1.049 (20/20℃)
color 
APHA: ≤10
Relative polarity
0.272
explosive limit
0.47%, 236°F
Water Solubility 
Slightly soluble. 0.0013 g/100 mL
FreezingPoint 
-35℃
Merck 
14,3035
BRN 
1914064
Henry's Law Constant
6.3 x 10-5 atm?m3/mol (quoted, Petrasek et al., 1983)
Exposure limits
NIOSH REL: TWA 5 mg/m3, IDLH 4,000 mg/m3; OSHA PEL: TWA 5 mg/m3; ACGIH TLV: TWA 5 mg/m3.
InChIKey
DOIRQSBPFJWKBE-UHFFFAOYSA-N
CAS DataBase Reference
84-74-2(CAS DataBase Reference)
Indirect Additives used in Food Contact Substances
DIBUTYL PHTHALATE
FDA 21 CFR
175.105; 176.170; 176.300; 177.1200; 177.2600
EWG's Food Scores
7-10
FDA UNII
2286E5R2KE
ATC code
P03BX03
Proposition 65 List
Di-n-butyl Phthalate (DBP)
NIST Chemistry Reference
Dibutyl phthalate(84-74-2)
EPA Substance Registry System
Dibutyl phthalate (84-74-2)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS02,GHS06,GHS07,GHS08,GHS09
Signal word  Danger
Hazard statements  H317-H320-H335-H361-H372-H373-H360-H225-H301+H311+H331-H360D-H370-H412-H360Df-H400
Precautionary statements  P201-P210-P260-P273-P280-P301+P310-P308+P313-P202-P264-P270-P271-P272-P302+P352+P333+P313+P363-P304+P340+P312-P305+P351+P338+P337+P313-P307+P311-P391-P403+P233-P405-P501-P501a
Hazard Codes  T,N,F
Risk Statements  61-50-62-39/23/24/25-23/24/25-11
Safety Statements  53-45-61-36/37-16
RIDADR  UN 3082 9/PG 3
WGK Germany  2
RTECS  TI0875000
Autoignition Temperature 756 °F
TSCA  Yes
HazardClass  9
PackingGroup  III
HS Code  29173100
Toxicity Acute oral LD50 for rats 8,000 mg/kg (RTECS, 1985).
NFPA 704
1
0 0

Dibutyl phthalate price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 40066 Di-n-butyl phthalate solution certified reference material, 5000?μg/mL in methanol 84-74-2 1 mL $48.7 2021-03-22 Buy
Sigma-Aldrich 18281 Dibutyl phthalate certified reference material, TraceCERT 84-74-2 50mg $87.1 2021-03-22 Buy
Sigma-Aldrich D1010000 Dibutyl phthalate European Pharmacopoeia (EP) Reference Standard 84-74-2 $190 2021-03-22 Buy
Sigma-Aldrich 753939 DBP 98% (HPLC) 84-74-2 250 mg $248 2021-03-22 Buy
Sigma-Aldrich 1187080 Dibutyl Phthalate United States Pharmacopeia (USP) Reference Standard 84-74-2 200mg $399 2021-03-22 Buy

Dibutyl phthalate Chemical Properties,Uses,Production

Description

Dibutyl phthalate is included as an insect repellent in some aerosol sprays used to treat flystrike in sheep. It is colorless oily liquid with a very weak aromatic odor.

Chemical Properties

Dibutyl phthalate occurs as an odorless, oily, colorless, or very slightly yellow-colored, viscous liquid.

Physical properties

Colorless to pale yellow, oily, viscous liquid with a mild, aromatic odor

Uses

Di-n-butyl phthalate has been used as an insect repellant.

Uses

Dibutyl phthalate is used in plasticizers, cosmetics, safety glass, insecticides, printing inks, paper coatings, adhesives, elastomers and explosives; solvent in polysulfide dental impression materials; solvent for perfume oils; perfume fixative; textile lubricating agent; solid rocket propellent; emollient in aerosol antiperspirants; insect repeller; plasticizer in various plastic materials.

Uses

A phthalate metabolite with genotoxic effect.

Uses

Plasticizer; solvent for oil-soluble dyes, insecticides and other organics; antifoam agent; textile fiber lubricant; manometer fluid; fragrance fixative; insect repellent.

Definition

ChEBI: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol.

Production Methods

Dibutyl phthalate is produced from n-butanol and phthalic anhydride in an ester formation reaction.

General Description

Dibutyl phthalate is a colorless oily liquid. Dibutyl phthalate is insoluble in water. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. Since Dibutyl phthalate is a liquid Dibutyl phthalate can easily penetrate the soil and contaminate groundwater and nearby streams. Dibutyl phthalate is combustible though Dibutyl phthalate may take some effort to ignite. Dibutyl phthalate is used in paints and plastics and as a reaction media for chemical reactions.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Dibutyl phthalate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Avoid contact with strong oxidizing agents and strong bases. Will not polymerize. [USCG, 1999]. Can generate electrostatic charges. [Handling Chemicals Safely 1980. p. 250].

Health Hazard

The toxicity of this compound is very low. Inhumans, oral intake of dibutyl phthalate at adose level of 150 mg/kg may cause nausea,vomiting, dizziness, hallucination, distortedvision, lacrimation, and conjunctivitis withprompt recovery. It metabolizes to monobutylester and phthalic acid and is excreted in urine.The inhalation toxicity should be insignificantbecause of its negligible low vapor pressure[<0.1 torr at 20°C (68°F)]. However, expo sure to its mist or aerosol can cause irritationof eyes and mucous membranes
LD50 value, oral (mice): 5300 mg/kg.

Fire Hazard

Combustible.

Pharmaceutical Applications

Dibutyl phthalate is used in pharmaceutical formulations as a plasticizer in film-coatings. It has been evaluated as a pore-forming agent in novel delivery systems.It is also used extensively as a solvent, particularly in cosmetic formulations such as antiperspirants, hair shampoos, and hair sprays. In addition to a number of industrial applications, dibutyl phthalate is used as an insect repellent, although it is not as effective as dimethyl phthalate.

Contact allergens

It is mainly used as a nonreactive epoxy diluent.

Safety Profile

Moderately toxic by intraperitoneal and intravenous routes. Mildly toxic by ingestion. Human systemic eye effects by ingestion, hallucinations, dstorted perceptions, nausea or vomiting, and kidney, ureter, or bladder changes. Experimental teratogenic and reproductive effects. Mutation data reported. Combustible when exposed to heat or flame; can react with oxidizing materials. Violent reaction with Cl2. Incompatible with chlorine. To fight fire, use CO2, dry chemical. When heated to decomposition it emits acrid smoke and fumes. See also ESTERS, PHTHALIC ACID, and n BUTYL ALCOHOL.

Safety

Dibutyl phthalate is generally regarded as a relatively nontoxic material, although it has occasionally been reported to cause hypersensitivity reactions. It is widely used in topical cosmetic and some oral pharmaceutical formulations.
LD50 (mouse, IV): 0.72g/kg
LD50 (mouse, oral): 5.3g/kg
LD50 (rat, oral): 8.0g/kg
LD50 (rat, IP): 3.05mL/kg

Source

Detected in distilled water-soluble fractions of new and used motor oil at concentrations of 38 to 43 and 15 to 23 μg/L, respectively (Chen et al., 1994). Leaching from flexible plastics in contact with water. Laboratory contaminant.

Environmental Fate

Biological. Under aerobic conditions using a freshwater hydrosol, mono-n-butyl phthalate and phthalic acid were produced. Under anaerobic conditions, phthalic acid was not present (Verschueren, 1983). In anaerobic sludge, di-n-butyl phthalate degraded as follows: monobutyl phthalate to phthalic acid to protocatechuic acid followed by ring cleavage and mineralization (Shelton et al., 1984). Engelhardt et al. (1975) reported that a variety of microorganisms were capable of degrading of di-n-butyl phthalate and suggested the following degradation scheme: di-n-butyl phthalate to mono-n-butyl phthalate to phthalic acid to 3,4-dihydroxybenzoic acid and other unidentified products. Di-n-butyl phthalate was degraded to benzoic acid by tomato cell suspension cultures (Lycopericon lycopersicum) (Pogány et al., 1990).
In a static-culture-flask screening test, di-n-butyl phthalate showed significant biodegradation with rapid adaptation. The ester (5 and 10 mg/L) was statically incubated in the dark at 25°C with yeast extract and settled domestic wastewater inoculum. After 7 days, 100% biodegradation was achieved (Tabak et al., 1981).
Soil. Under aerobic conditions using a fresh-water hydrosol, mono-n-butyl phthalate and phthalic acid were produced. Under anaerobic conditions, however, phthalic acid was not formed (Verschueren, 1983).
Photolytic. An aqueous solution containing titanium dioxide and subjected to UV radiation (l >290 nm) produced hydroxyphthalates and dihydroxyphthalates as intermediates (Hustert and Moza, 1988).
Chemical/Physical. Pyrolysis of di-n-butyl phthalate in the presence of polyvinyl chloride at 600°C gave the following compounds: indene, methylindene, naphthalene, 1- methylnaphthalene, 2-methylnaphthalene, biphenyl, dimethylnaphthalene, acenaphthene, fluorene, methylacenaphthene, methylfluorene and six unidentified compounds (Bove and Dalven, 1984).
Under alkaline conditions, di-n-butyl phthalate will initially hydrolyze to n-butyl hydrogen phthalate and n-butanol. The monoester will undergo further hydrolysis forming o-phthalic acid and n-butanol (Kollig, 1993).

storage

Dibutyl phthalate should be stored in a well-closed container in a cool, dry, location. Containers may be hazardous when empty since they can contain product residues such as vapors and liquids.

Purification Methods

Wash DBP with H2O (to free it from alcohol), then dilute NaOH (to remove any butyl hydrogen phthalate or acid), aqueous NaHCO3 (charcoal), then distilled water. Dry it (CaCl2), distil it at 10torr or less, and store it in a desiccator over P2O5. [Beilstein 9 II 586, 9 III 4102, 9 IV 3175.]

Toxicity evaluation

Acute oral LD50 for rats: >6,000 mg/kg

Incompatibilities

Dibutyl phthalate reacts violently with chlorine. It also reacts with oxidizing agents, acids, bases, and nitrates.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral capsules, delayed action, enteric coated, and controlled release tablets). Included in nonparenteral medicines licensed in the UK (oral capsules, tablets, granules; topical creams and solutions).

Dibutyl phthalate Preparation Products And Raw materials

Raw materials

Preparation Products


Dibutyl phthalate Suppliers

Global( 502)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Wuhan Fortuna Chemical Co., Ltd
86-27-59207850
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0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
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+86-025-86655873
marketing@royal-chem.com CHINA 536 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
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+8613734021967
kaia@neputrading.com CHINA 1009 58
career henan chemical co
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View Lastest Price from Dibutyl phthalate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-03 Dibutyl phthalate
84-74-2
US $10.00 / KG/Tin 1KG 99% 5000tons per month Wuhan Mulei New Material Technology Co. Ltd
2021-12-01 Dioctyl Phthalate
84-74-2
US $10.50 / KG 1KG 99% 10 ton Hebei Crovell Biotech Co Ltd
2021-10-14 Dibutyl phthalate;DBP
84-74-2
US $1.60 / Kg/Drum 5T 98%;99%;99.5% 1000tons/month Hebei Dongdu Import and Export Co. LTD

Dibutyl phthalate Spectrum


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