(±)-(3R*,4S*)-2-Oxo-4-phenyl-3-pyrollidinecarboxylicacid2-[1-(3-bromophenyl)ethylidene]hydrazide
- CAS No.
- 1051487-82-1
- Chemical Name:
- (±)-(3R*,4S*)-2-Oxo-4-phenyl-3-pyrollidinecarboxylicacid2-[1-(3-bromophenyl)ethylidene]hydrazide
- Synonyms
- AC 264613;2-(DIMETHYLAMINO)ETHYL 2-(2-ETHYLBUTOXY)-2,2-DIPHENYLACETATE;(±)-(3R*,4S*)-2-Oxo-4-phenyl-3-pyrollidinecarboxylicacid2-[1-(3-bromophenyl)ethylidene]hydrazide;3-Pyrrolidinecarboxylic acid, 2-oxo-4-phenyl-, 2-[1-(3-bromophenyl)ethylidene]hydrazide, (3R,4S)-rel-
- CBNumber:
- CB72518775
- Molecular Formula:
- C19H18BrN3O2
- Molecular Weight:
- 400.27
- MDL Number:
- MFCD18086869
- MOL File:
- 1051487-82-1.mol
(±)-(3R*,4S*)-2-Oxo-4-phenyl-3-pyrollidinecarboxylicacid2-[1-(3-bromophenyl)ethylidene]hydrazide Properties
Density | 1.46±0.1 g/cm3(Predicted) |
---|---|
storage temp. | Store at -20°C |
solubility | <40.03mg/ml in DMSO |
form | solid |
pka | 10.50±0.40(Predicted) |
color | White |
FDA UNII | 1ST2P4BE17 |
(±)-(3R*,4S*)-2-Oxo-4-phenyl-3-pyrollidinecarboxylicacid2-[1-(3-bromophenyl)ethylidene]hydrazide price More Price(10)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Tocris | 3370 | AC264613 ≥98%(HPLC) | 1051487-82-1 | 10 | $195 | 2021-12-16 | Buy |
Tocris | 3370 | AC264613 ≥98%(HPLC) | 1051487-82-1 | 50 | $839 | 2021-12-16 | Buy |
TRC | A188950 | AC264613 | 1051487-82-1 | 1mg | $95 | 2021-12-16 | Buy |
Usbiological | 254510 | AC 264613 | 1051487-82-1 | 10mg | $438 | 2021-12-16 | Buy |
TRC | A188950 | AC264613 | 1051487-82-1 | 10mg | $595 | 2021-12-16 | Buy |
(±)-(3R*,4S*)-2-Oxo-4-phenyl-3-pyrollidinecarboxylicacid2-[1-(3-bromophenyl)ethylidene]hydrazide Chemical Properties,Uses,Production
Uses
AC 264613 is a selective protease-activated receptor 2 (PAR-2) agonist. AC 264613 can be used to investigate the physiological roles of the PAR-?2 receptors.
Biological Activity
ac 264613 is a potent agonist of par2 with pec50 value of 7.5 and potencies range from 30 to 100 nm [1, 2].protease-activated receptor 2 (par2) also known as coagulation factor ii (thrombin) receptor-like 1 (f2rl1) or g-protein coupled receptor 11 (gpr11) is expressed in vascular tissue and highly vascular organs and involves in the vascular tone regulation. it has been shown that par2 plays a pivotal role in vessel inflammation and wound healing processes [2].ac 264613 is a selective par2 agonist and has no effect on other pars. when tested with hek 293 t cells (par2 wild type) and knrk cells (transfected with human par2 receptors) for stimulates pi hydrolysis and ca2+ mobilization assays, ac 264613 showed effect with pec50 value of 6.9 and 7.0,respectively [1]. using quickchange mutagenesis manner, nih 3t3 cells were made with ecl2 mutations in q233e, e232r, e232r/q233r, f240s, and f240s/s37p receptors and ac 264613 treatment par2 f240s receptors were constitutively expressed in multiple functional endpoints while had no effect on e232 and q233 mutaions [2].in male sprague-dawley rat model with acute thermal nociception and edema in paw induced by sligrl-nh2 or trypsin, intrapaw administration of ac 264613 induced hind paw edema and thermal hyperalgesia at the doses as low as 30 ng and showed dose-dependent pronociceptive effects [1].
storage
Store at -20°C
References
[1]. gardell, l.r., et al., identification and characterization of novel small-molecule protease-activated receptor 2 agonists. j pharmacol exp ther, 2008. 327(3): p. 799-808.
[2]. ma, j.n. and e.s. burstein, the protease activated receptor 2 (par2) polymorphic variant f240s constitutively activates par2 receptors and potentiates responses to small-molecule par2 agonists. j pharmacol exp ther, 2013. 347(3): p. 697-704.
(±)-(3R*,4S*)-2-Oxo-4-phenyl-3-pyrollidinecarboxylicacid2-[1-(3-bromophenyl)ethylidene]hydrazide Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
Medi-tech Bioscientific Co., Ltd. | 0519-83246372 13585352506 | China | 1844 | 58 | |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10000 | 58 |