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TC-A 2317 hydrochloride

TC-A 2317 hydrochloride Structure
TC-A 2317 hydrochloride structure
CAS No.
1245907-03-2
Chemical Name:
TC-A 2317 hydrochloride
Synonyms
TC-A-2317 HCl;Reaxys ID: 20640556;TC-A 2317 hydrochloride;2-[(5-Hydroxy-1,5-dimethylhexyl)amino]-4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile hydrochloride;permeability,oral,Inhibitor,selective,antitumor,inhibit,HCT-116,TC A 2317 hydrochloride,TCA 2317 hydrochloride,Aurora Kinase,proliferation,TC-A 2317
CBNumber:
CB72535699
Molecular Formula:
C19H29ClN6O
Molecular Weight:
392.93
MDL Number:
MFCD19690936
MOL File:
1245907-03-2.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59
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TC-A 2317 hydrochloride Properties

storage temp. Store at 4°C
solubility Soluble to 100 mM in DMSO and to 50 mM in ethanol
form Powder

TC-A 2317 hydrochloride price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML2446 TC-A2317 hydrochloride ≥98% (HPLC) 1245907-03-2 5mg $98.4 2024-03-01 Buy
Sigma-Aldrich SML2446 TC-A2317 hydrochloride ≥98% (HPLC) 1245907-03-2 25mg $237.6 2024-03-01 Buy
Tocris 4066 TC-A2317 hydrochloride ≥98%(HPLC) 1245907-03-2 10 $258 2021-12-16 Buy
Tocris 4066 TC-A2317 hydrochloride ≥98%(HPLC) 1245907-03-2 50 $1029 2021-12-16 Buy
Usbiological 256829 TC-A 2317 hydrochloride 1245907-03-2 10mg $516 2021-12-16 Buy
Product number Packaging Price Buy
SML2446 5mg $98.4 Buy
SML2446 25mg $237.6 Buy
4066 10 $258 Buy
4066 50 $1029 Buy
256829 10mg $516 Buy

TC-A 2317 hydrochloride Chemical Properties,Uses,Production

Biochem/physiol Actions

TC-A2317 (TC-A 2317) is an orally active, potent and selective aurora A kinase inhibitor (Ki = 1.2 nM; Aurora B Ki = 101 nM; IC50 >1 μM toward 60 other kinases). TC-A2317 inhibits the proliferation of human colorectal carcinoma HCT116 cells in cultures (IC50 = 115 nM) and suppresses HCT116 xenograft-derived tumor growth in mice in vivo (by 59% on day 14; 30 mg/kg/day p.o.) with good pharmacokinectic properties, oral bioavailability (Tmax = 1.2 h, T1/2 = 3.3 h, Cmax = 4930 nM, C60 min = 52 nM in rat serum post 30 mg/kg p.o.), and no adverse effects to the animals. TC-A231 is a racemate with its (S)-enantiomer being more active than the (R)-enantiomer (respective Ki = 0.59 vs. 66 nM).

storage

Store at +4°C

TC-A 2317 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

TC-A 2317 hydrochloride Suppliers

Global( 16)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 14059 65
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369 3477467573@qq.com China 8618 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24131 58
ApexBio Technology -- sales@apexbt.com United States 6254 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
BOC Sciences 65
MedBioPharmaceutical Technology Inc 58
Changzhou Furuisi Biotechnology Co., Ltd 58
TargetMol Chemicals Inc. 58
ApexBio Technology 58
TC-A 2317 hydrochloride TC-A-2317 HCl 2-[(5-Hydroxy-1,5-dimethylhexyl)amino]-4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile hydrochloride Reaxys ID: 20640556 permeability,oral,Inhibitor,selective,antitumor,inhibit,HCT-116,TC A 2317 hydrochloride,TCA 2317 hydrochloride,Aurora Kinase,proliferation,TC-A 2317 1245907-03-2 C19H28N6OClH C19H28N6OHCl