Chinese Japanese Germany

Ethyl acetate

Introduction Solubility in water Purification and water removal methods Uses Production Category Toxicity grading Acute oral toxicity Irritation data Hazardous characteristics of explosive Flammability and hazard characteristics Storage characteristics Extinguishing agent Professional standards
Ethyl acetate
Ethyl acetate
Chemical Name:
Ethyl acetate
ETOH;Etile;EtOAc;Ethyle;SPIRIT;ALCOHOL;Vinasse;Acetidin;FEMA 2414;ai3-00404
Molecular Formula:
Formula Weight:
MOL File:

Ethyl acetate Properties

Melting point:
−84 °C(lit.)
Boiling point:
76.5-77.5 °C(lit.)
0.902 g/mL at 25 °C(lit.)
vapor density 
3 (20 °C, vs air)
vapor pressure 
73 mm Hg ( 20 °C)
refractive index 
n20/D 1.3720(lit.)
Flash point:
26 °F
storage temp. 
Miscible with ethanol, acetone, diethyl ether and benzene.
16-18(at 25℃)
APHA: ≤10
Relative polarity
explosive limit
2.2-11.5%, 38°F
Water Solubility 
80 g/L (20 ºC)
Stable. Incompatible with various plastics, strong oxidizing agents. Highly flammable. Vapour/air mixtures explosive. May be moisture sensitive.
CAS DataBase Reference
141-78-6(CAS DataBase Reference)
NIST Chemistry Reference
Ethyl acetate(141-78-6)
EPA Substance Registry System
Acetic acid ethyl ester(141-78-6)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  F,Xi,Xn,T
Risk Statements  11-36-66-67-20/21/22-10-39/23/24/25-23/24/25-68/20/21/22
Safety Statements  16-26-33-36/37-45-7-25
RIDADR  UN 1173 3/PG 2
WGK Germany  1
RTECS  AH5425000
HazardClass  3
PackingGroup  II
Hazardous Substances Data 141-78-6(Hazardous Substances Data)
Toxicity LD50 orally in rats: 11.3 ml/kg (Smyth)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warning P264, P305+P351+P338,P337+P313
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P307+P311 IF exposed: call a POISON CENTER or doctor/physician.
P370+P378 In case of fire: Use … for extinction.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P403+P235 Store in a well-ventilated place. Keep cool.
P501 Dispose of contents/container to..…

Ethyl acetate price More Price(112)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 187380 Ethyl alcohol, denatured 1l $62.9 2018-11-22 Buy
Sigma-Aldrich 1265402 Ethyl acetate Pharmaceutical Secondary Standard; Certified Reference Material 141-78-6 3x1.2ml $76.7 2018-11-13 Buy
TCI Chemical A0030 Ethyl Acetate [for Spectrophotometry] >99.5%(GC) 141-78-6 250mL $40 2018-11-22 Buy
Alfa Aesar 022912 Ethyl acetate, HPLC Grade, 99.5+% 141-78-6 1L $50.8 2018-11-16 Buy
Alfa Aesar 022912 Ethyl acetate, HPLC Grade, 99.5+% 141-78-6 *4x1L $172 2018-11-16 Buy

Ethyl acetate Chemical Properties,Uses,Production


Ethyl Acetate is an organic ester compound with a molecular formula of C4H8O2 (commonly abbreviated as EtOAc or EA), appears as a colorless liquid. It is highly miscible with all common organic solvents (alcohols, ketones, glycols, esters), which make it a common solvent for cleaning, paint removal and coatings.
Ethyl acetate is found in alcoholic beverages, cereal crops, radishes, fruit juices, beer, wine, spirits etc. It has a fruity characteristic odor that is commonly recognized in glues, nail polish remover, decaffeinating tea and coffee, and cigarettes. Due to its agreeable aroma and low cost, this chemical is commonly used and manufactured in large scale in the world, as over 1 million tons annually.

Solubility in water

8.3 g/100 mL (20 °C)

Purification and water removal methods

Ethyl acetate generally has a content of 95% to 98% containing a small amount of water, ethanol and acetic acid. It can be further purified as following: add 100mL of acetic anhydride into 1000mL of ethyl acetate; add 10 drops of concentrated sulfuric acid, heat and reflux for 4h to remove impurities such as ethanol and water, and then further subject to distillation. Distillate is oscillated by 20~30g of anhydrous potassium carbonate and further subject to re-distillation. The product has a boiling point of 77 °C and purity being over 99%.


Industry Applications Role/Benefit
Flavor and essence Food flavor Used largely to prepare bananas, pears, peaches, pineapple and grape scent food flavors, etc
Alcoholic essence Used slightly as fragrance volatile
Perfume essence Used slightly as fragrance volatile
Chemical manufacture Production of acetamide, acetyl acetate, methyl heptanone, etc Organic chemical raw materials
Production of organic acid Extracting agent
Laboratory Dilution and extraction Supply excellent dissolving capacity
Chromatographic analysis Standard material
Column chromatography and extractions Main component of mobile phase
Reaction solvent Be prone to hydrolysis and transesterification
Chemical analysis Thermometer calibration for sugar separation  Standard material
Determination of bismuth, boron, gold, molybdenum, platinum and thallium Solvent
Entomology Insect collecting and study Used as effective asphyxiant to kill the collected insect quickly without destroying it
Textile industry Cleaning agent Supply excellent dissolving capacity
Printing Flexographic and rotogravure printing Dissolve the resin, control the viscosity and modify the drying rate
Electronics industry Viscosity reducer Reduce the viscosity of resins used in photoresist formulations
Paint manufacture Solvent Dissolve and dilute the paints
Health & personal care products The formulation of nail polish, nail polish removers and other manicuring products Supply excellent dissolving capacity
Pharmaceutical Medicine manufacturing Extraction agent; intermediate
Cosmetics Aroma enhancer In perfume to enhance aroma
Others Tanning extracts Used for desulfurization of tanning, cigarette materials, oil field drilling, metal flotation, descaling, etc
Production of adhesive Solvent
Extract many compounds (phosphorus, cobalt, tungsten, arsenic) from aqueous solution Extracting agent


Industrial production of ethyl acetate is mainly classified into three processes.

The first one is a classical Fischer esterification process of ethanol with acetic acid in presence of acid catalyst. This process needs acid catalyst2 such as sulphuric acid, hydrochloride acid, ptoluene sulfonic acid etc. This mixture converts to the ester in about 65% yield at room temperature. 
The reaction can be accelerated by acid catalysis and the equilibrium can be shifted to the right by removal of water.

The second one is Tishchenko Reaction of acetaldehyde using aluminium triethoxide as a catalyst. In Germany and Japan, most ethyl acetate is produced via the Tishchenko process. 
This method has been proposed by two different routes; (i) dehydrogenative process, which uses copper or palladium based catalyst and (ii) the oxidative one, which employs, PdO supported catalysts.

The third one, which has been recently commercialized, is addition of acetic acid to ethylene using clay and heteroploy acid7 as a catalyst. 
The processes, however, have some disadvantages; both the conventional esterification and addition of acetic acid to ethylene need stock tanks and apparatus for several feed stocks. Moreover, they use acetic acid that causes apparatus corrosion. Although Teshchenko Reaction uses only one feed and it is a non-corrosive material, it is difficult to handle acetaldehyde because is not available outside of petrochemical industrial area.
In such circumstances, an improved process of ethyl acetate production is strongly desired.


Flammable liquid

Toxicity grading


Chemical Properties


Chemical Properties

Ethyl acetate is a colorless liquid. Pleasant, fruity odor.


Pharmaceutic aid (flavor); artificial fruit essences; solvent for nitrocellulose, varnishes, lacquers, and aeroplane dopes; manufacture of smokeless powder, artificial leather, photographic films and plates, artificial silk, perfumes; cleaning textiles, etc.

Acute oral toxicity

rat LD50: 5620 mg/kg; Oral-Mouse LD50: 4100 mg/kg

Irritation data

eye-people 400 PPM

Hazardous characteristics of explosive

explosive when mixed with air

Flammability and hazard characteristics

it is flammable in case of fire, high temperature, and oxidant with burning causing irritated smoke

Storage characteristics

Treasury: ventilation, low-temperature and dry; store it separately from oxidants

Extinguishing agent

dry powder, dry sand, carbon dioxide, foam, and 1211 fire extinguishing agent

Professional standards

TWA 1400 mg/m³; STEL 2000 mg/m³

Air & Water Reactions

Highly flammable. Slightly soluble in water. Ethyl acetate is slowly hydrolyzed by moisture.

Reactivity Profile

Ethyl acetate is also sensitive to heat. On prolonged storage, materials containing similar functional groups have formed explosive peroxides. Ethyl acetate may ignite or explode with lithium aluminum hydride. Ethyl acetate may also ignite with potassium tert-butoxide. Ethyl acetate is incompatible with nitrates, strong alkalis and strong acids. Ethyl acetate will attack some forms of plastics, rubber and coatings. Ethyl acetate is incompatible with oxidizers such as hydrogen peroxide, nitric acid, perchloric acid and chromium trioxide. Violent reactions occur with chlorosulfonic acid. . SOCl2 reacts with esters, such as Ethyl acetate, forming toxic SO2 gas and water soluble/toxic acyl chlorides, catalyzed by Fe or Zn (Spagnuolo, C.J. et al. 1992. Chemical and Engineering News 70(22):2.).


Toxic by inhalation and skin absorption; irritant to eyes and skin. Flammable, dangerous fire and explosion risk, flammable limits in air 2.2–9%. Questionable carcinogen.

Health Hazard

Headache, irritation of respiratory passages and eyes, dizziness and nausea, weakness, loss of consciousness.

Health Hazard

The acute toxicity of ethyl acetate is low. Ethyl acetate vapor causes eye, skin, and respiratory tract irritation at concentrations above 400 ppm. Exposure to high concentrations may lead to headache, nausea, blurred vision, central nervous system depression, dizziness, drowsiness, and fatigue. Ingestion of ethyl acetate may cause gastrointestinal irritation and, with larger amounts, central nervous system depression. Eye contact with the liquid can produce temporary irritation and lacrimation. Skin contact produces irritation. Ethyl acetate is regarded as a substance with good warning properties. No chronic systemic effects have been reported in humans, and ethyl acetate has not been shown to be a human carcinogen, reproductive, or developmental toxin

Fire Hazard

Ethyl acetate is a flammable liquid (NFPA rating = 3), and its vapor can travel a considerable distance to an ignition source and "flash back." Ethyl acetate vapor forms explosive mixtures with air at concentrations of 2 to 11.5% (by volume). Hazardous gases produced in ethyl acetate fires include carbon monoxide and carbon dioxide. Carbon dioxide or dry chemical extinguishers should be used for ethyl acetate fires

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Safety Profile

Potentially poisonous by ingestion. Toxicity depends upon alcohols in question, generally ethanol with methanol as a denaturant. A flammable liquid and dangerous fire hazard; can react vigorously with oxidzing materials. Moderate explosion hazard. See ETHANOL, METHYL ALCOHOL, and n-PROPYL ALCOHOL.

Potential Exposure

This material is used as a solvent for nitrocellulose and lacquer. It is also used in making dyes,flavoring and perfumery, and in smokeless powder manufacture

First aid

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.


UN1173 Ethyl acetate, Hazard Class: 3; Labels: 3-Flammable liquid.

Purification Methods

The most common impurities in EtOAc are water, EtOH and acetic acid. These can be removed by washing with aqueous 5% Na2CO3, then with saturated aqueous CaCl2 or NaCl, and drying with K2CO3, CaSO4 or MgSO4. More efficient drying is achieved if the solvent is further dried with P2O5, CaH2 or molecular sieves before distillation. CaO has also been used. Alternatively, ethanol can be converted to ethyl acetate by refluxing with acetic anhydride (ca 1mL per 10mL of ester), the liquid is then fractionally distilled, dried with K2CO3 and redistilled. [Beilstein 2 III 127.]


May form explosive mixture with air. Heating may cause violent combustion or explosion. Incompatible with strong acids; strong alkalies; nitrates, strong oxidizers; chlorosulfonic acid; lithium aluminum hydride; oleum will hydrolyze on standing forming acetic acid and ethyl alcohol. This reaction is greatly accelerated by alkalies. Decomposes under influence of UV light, bases, and acids. Attacks aluminum and plastics.

Waste Disposal

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≧100 kg/ mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

Ethyl acetate Preparation Products And Raw materials

Raw materials

Preparation Products

Ethyl acetate Suppliers

Global( 476)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37127788 CHINA 500 55
Hebei Guanlang Biotechnology Co., Ltd.
+86-0311-66562153 whatsapp +8615203118427
+86-0311-66562153 CHINA 417 50
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22063 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20795 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555 CHINA 1374 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32764 55
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 CHINA 14297 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 1582 55
Meihua Biological Technology Co.,Ltd
031145896235 CHINA 223 58
Yancheng Green Chemicals Co.,Ltd
86-515-87883652 CHINA 337 58

View Lastest Price from Ethyl acetate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-09-19 ethyl acetate
US $40.00 / KG 1KG 99% 20 MT Hebei Huanhao Biotechnology Co., Ltd.
2018-05-23 ethyl acetate
US $10.00 / KG 1000KG 99% 1000 ton Meihua Biological Technology Co.,Ltd
2018-09-22 Hot selling Ethyl acetate CAS NO.141-78-6
US $1.00 / G 100G 99.9% 5000 tons Hebei Ruishun Trade Co.,Ltd

Ethyl acetate Spectrum

141-78-6(Ethyl acetate)Related Search:

Copyright 2017 © ChemicalBook. All rights reserved