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ChemicalBook >> CAS DataBase List >>2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- Structure
2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- structure
CAS No.
865305-30-2
Chemical Name:
2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-
Synonyms
Ro 4;AF 353;CS-2469;CHEMBL526307;AF-353 (Ro-4);CHEMBL526307;AF 353;AF353;5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidine-2,4-diamine;Ro4,inhibit,AF-353,P2X Receptor,Inhibitor,Ro 4,P2XRs,AF353,AF 353;5-[5-Iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine;2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-
CBNumber:
CB72609596
Molecular Formula:
C14H17IN4O2
Molecular Weight:
400.21
MDL Number:
MFCD18782750
MOL File:
865305-30-2.mol
Last updated:2023-09-20 16:43:00
Request For Quotation

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- Properties

Boiling point 510.2±60.0 °C(Predicted)
Density 1.619±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : ≥ 32 mg/mL (79.96 mM)
pka 6.89±0.10(Predicted)

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 23034 AF-353 865305-30-2 1mg $32 2022-04-27 Buy
Cayman Chemical 23034 AF-353 865305-30-2 5mg $102 2022-04-27 Buy
Cayman Chemical 23034 AF-353 865305-30-2 10mg $189 2022-04-27 Buy
AK Scientific 1897CW 2,4-Pyrimidinediamine,5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]- 865305-30-2 10mg $245 2021-12-16 Buy
ChemScene CS-5061 AF-353 98.95% 865305-30-2 25mg $310 2021-12-16 Buy
Product number Packaging Price Buy
23034 1mg $32 Buy
23034 5mg $102 Buy
23034 10mg $189 Buy
1897CW 10mg $245 Buy
CS-5061 25mg $310 Buy

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- Chemical Properties,Uses,Production

Description

AF-353 is a noncompetitive dual antagonist of the purinoreceptors P2X3 and P2X2/3 (IC50s = 10 and 79.4 nM, respectively). It is selective for P2X3 and P2X2/3 over P2X1, P2X2, P2X4, P2X5, and P2X7 (IC50 = >10 μM for all). It inhibits calcium flux in CHO-K1 cells expressing the rat P2X3 receptor and in 1321N1 cells expressing the human P2X3 and P2X2/3 receptors (IC50s = 8.91, 8.71, and 38.9 nM, respectively). AF-353 decreases the electrical signals in the detrusor, but not striated, muscle of the bladder in female rats.

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- Preparation Products And Raw materials

Raw materials

Preparation Products

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- Suppliers

Global( 73)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21149 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
CR Corporation Lomited 		fred.wen@crcorporation.cn CHINA 12069 58
Hong Kong Tiansheng New Material Trading Co., Ltd 		+8617320695765 zxx@hktiansheng.com China 981 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43348 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
BOC Sciences 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
TargetMol Chemicals Inc. 		58
CR Corporation Lomited 		58
Hong Kong Tiansheng New Material Trading Co., Ltd 		58
InvivoChem 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
LEAPCHEM CO., LTD. 		58
Aladdin Scientific 		58

View Lastest Price from 2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
af-353 pictures 2022-02-25 af-353
865305-30-2
 US $100.00 / KG 1KG 98% 100KG Hong Kong Tiansheng New Material Trading Co., Ltd
af-353 pictures 2022-02-25 af-353
865305-30-2
 US $100.00 / Kg/Bag 1KG 99% 10kg Hong Kong Tiansheng New Material Trading Co., Ltd
  • af-353 pictures
  • af-353
    865305-30-2
  • US $100.00 / KG
  • 98%
  • Hong Kong Tiansheng New Material Trading Co., Ltd
  • af-353 pictures
  • af-353
    865305-30-2
  • US $100.00 / Kg/Bag
  • 99%
  • Hong Kong Tiansheng New Material Trading Co., Ltd

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- Spectrum

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-(865305-30-2)1HNMR
2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- AF 353 Ro 4 5-{[5-iodo-2-(1-Methylethyl)-4-(Methyloxy)phenyl]oxy}-2,4-pyriMidinediaMine AF-353 (Ro-4) 5-[5-Iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine hydrochloride Ro 4 hydrochloride CS-2469 CHEMBL526307;AF 353;AF353 CHEMBL526307 5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidine-2,4-diamine Ro4,inhibit,AF-353,P2X Receptor,Inhibitor,Ro 4,P2XRs,AF353,AF 353 865305-30-2 C14H17IN4O2 Inhibitors