ChemicalBook >> CAS DataBase List >>CFI-401870
CFI-401870
- CAS No.
- 1430741-35-7
- Chemical Name:
- CFI-401870
- Synonyms
- CFI401870;CFI-401870;1H-Indazole-5-carboxamide, N-[(R)-cyclopropyl-2-pyridinylmethyl]-3-[4-[(3-endo)-3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl]phenyl]-
- CBNumber:
- CB73118668
- Molecular Formula:
- C30H31N5O2
- Molecular Weight:
- 493.6
- MDL Number:
- MOL File:
- 1430741-35-7.mol
Last updated:2023-07-12 17:05:42
CFI-401870 Chemical Properties,Uses,Production
Description
CFI-401870 is a orally bioavailable, potent tyrosine threonine kinase (TTK) Inhibitor (TTK IC50 < 10 nM, HCT116 GI50 < 0.1 μM). CFI-401870 displayed low off-target activity (>500×), and microsomal stability (T(1/2) > 30 min). CFI-401870 recapitulated the phenotype of TTK RNAi, demonstrated in vivo tumor growth inhibition upon oral dosing, and was selected for preclinical evaluation.
CFI-401870 Preparation Products And Raw materials
Raw materials
Preparation Products
CFI-401870 Suppliers
Global( 6)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Hangzhou Synstar pharmaceutical Technology CO.,Ltd | 0571-85361029 | synstar518@163.com | China | 1991 | 58 |
| Hubei Kele Fine Chemical Co., Ltd | 027-59101668 19945030958 | 2881924765@qq.com | China | 7973 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| https://hanhongsci.com/ | 021-54306202 18917919676 | info@hanhongsci.com | China | 29990 | 58 |
CFI401870
CFI-401870
1H-Indazole-5-carboxamide, N-[(R)-cyclopropyl-2-pyridinylmethyl]-3-[4-[(3-endo)-3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl]phenyl]-
1430741-35-7