1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT
- CAS No.
- 124011-52-5
- Chemical Name:
- 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT
- Synonyms
- 1,2-Distearoyl-rac-glycero-3-PG (sodium salt);(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium;1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT;sodium 2,3-bis(stearoyloxy)propyl (2,3-dihydroxypropyl) phosphate;1,2-distearoyl-sn-glycero-3-phosphatidyl-rac-glycerol sodium salt;Octadecanoic acid,1-[[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester,sodium salt
- CBNumber:
- CB7380181
- Molecular Formula:
- C42H84NaO10P
- Molecular Weight:
- 803.09
- MDL Number:
- MFCD03454063
- MOL File:
- 124011-52-5.mol
1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 15087 | 1,2-Distearoyl-rac-glycero-3-PG (sodium salt) ≥98% | 124011-52-5 | 100 mg | $82 | 2024-03-01 | Buy |
| Cayman Chemical | 15087 | 1,2-Distearoyl-rac-glycero-3-PG (sodium salt) ≥98% | 124011-52-5 | 250 mg | $194 | 2024-03-01 | Buy |
| Cayman Chemical | 15087 | 1,2-Distearoyl-rac-glycero-3-PG (sodium salt) ≥98% | 124011-52-5 | 500 mg | $368 | 2024-03-01 | Buy |
1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT Chemical Properties,Uses,Production
Description
DSPG is used in FDA approved drugs. It is an anionic phospholipid derivative. DSPG has been used to form an ionic complex with amphotericin B and encapsulate it into small unilamellar liposomes with significantly reduced toxicity (AmBisome?). DSPG-Na is a lipid reagent, which is useful in drug formulation, DNA & RNA delivery.
in vitro
Three liposome formulations were investigated: HSPC:Chol (L-EPI; 5:4 molar ratio), HSPC:Chol:DSPG (D-EPI; 5:4:1 molar ratio), and HSPC:Chol:DSPG:DSPE-mPEG(2000) (S-EPI; 5:4:1:0.3 molar ratio). Small unilamellar liposomes were prepared by the modified thin-film hydration method with extrusion through polycarbonate filters, and EPI was remote loaded into liposomes by the transmembrane ammonium sulfate gradient method._x000D_ _x000D_ Reference: J Liposome Res. 2012 Mar;22(1):80-8. https://pubmed.ncbi.nlm.nih.gov/22022836/
in vivo
Vaccination of atherosclerotic mice on a western-type diet with DSPG-liposomes encapsulating an LDL-derived peptide antigen significantly reduced plaque formation by 50% and stabilized the plaques, and reduced serum cholesterol concentrations. These results indicate that DSPG-liposomes have potential as a delivery system in vaccination against atherosclerosis._x000D_ _x000D_ Reference: J Control Release. 2018 Dec 10;291:135-146. https://pubmed.ncbi.nlm.nih.gov/30365993/
target
A phospholipid.
1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT Preparation Products And Raw materials
Raw materials
Preparation Products
1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 13349 | 58 |
| Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai Likang New Materials Co., Limited | +86-16631818819 +86-17736933208 | 3684455296@qq.com | China | 9311 | 58 |
| Suzhou Highfine Biotech Co., Ltd | 0512-69209928 18306209933 | joyce@highfine.com | China | 498 | 75 |
| Yichang Zhongyitai Trading Co., Ltd. | 0717-6449896 13886658719 | root@zhongyitai.com | China | 1977 | 58 |
| Wellman Pharmaceutical Group Limited | 027-027-83778875 15807197853 | 15807197853@163.com | China | 4007 | 58 |
| Suzhou C1 Technology Co.，Ltd | 18606219109 | ty.sales1@feixiangchem.com | China | 70 | 58 |
| Beijing Minruida Technology Co., Ltd. | 010-82387566 18001021521; | sales@mreda.com.cn | China | 10790 | 58 |
| Tianjin Kaifu Pharmaceutical Technology Co., Ltd. | 18081075745 | chemflowtech@sina.com | China | 1886 | 58 |
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