NSC 95397
- CAS No.
- 93718-83-3
- Chemical Name:
- NSC 95397
- Synonyms
- NSC 95397;Cdc25 Inhibitor IV, NSC 95397;2,3-BIS[(2-HYDROXYETHYL)THIO]-1,4-NAPHTHOQUINONE;2,3-BIS(2-HYDROXYETHYLTHIO)-1,4-NAPHTHALENEDIONE;2,3-BIS[(2-HYDROXYETHYL)THIOL]-1,4-NAPHTHOQUINONE;1,4-Naphthalenedione, 2,3-bis[(2-hydroxyethyl)thio]-;Cdc25 Inhibitor IV, NSC 95397 - CAS 93718-83-3 - Calbiochem;Apoptosis,NSC-95397,Inhibitor,NSC 95397,inhibit,NSC95397,Phosphatase
- CBNumber:
- CB7402539
- Molecular Formula:
- C14H14O4S2
- Molecular Weight:
- 310.39
- MDL Number:
- MFCD04040032
- MOL File:
- 93718-83-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H317 | |||||||||
| Precautionary statements | P261-P264-P272-P280-P302+P352-P305+P351+P338-P333+P313-P321-P337+P313-P363-P501 | |||||||||
| Hazard Codes | Xi | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| NFPA 704 |
|
NSC 95397 price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N1786 | NSC 95397 ≥97% (HPLC) | 93718-83-3 | 5mg | $129 | 2024-03-01 | Buy |
| Sigma-Aldrich | 217694 | Cdc25 Inhibitor IV, NSC 95397 | 93718-83-3 | 10mg | $159 | 2024-03-01 | Buy |
| Cayman Chemical | 21431 | NSC 95397 ≥98% | 93718-83-3 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 21431 | NSC 95397 ≥98% | 93718-83-3 | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 21431 | NSC 95397 ≥98% | 93718-83-3 | 10mg | $138 | 2024-03-01 | Buy |
NSC 95397 Chemical Properties,Uses,Production
Description
NSC 95397 (93718-83-3) is a potent and selective inhibitor of Cdc25 phosphatase (Ki? = 32, 96 and 40 nM for Cdc25A, B and C respectively). NSC-95397 inhibits the growth of several human tumor cell lines and blocks G2/M cell cycle transition.1 Induces cell cycle arrest, phosphorylation of EGFR and activation of ERK-1 and -2.2 Inhibits carboxyl-terminal binding protein a transcriptional corepressor that suppresses multiple pro-apoptotic and epithelial genes.3 Induces eryptosis in human erythrocytes.4
Uses
NSC 95397 is a quinone-based Cdc25 inhibitor, caspase-3 activator, ERK activator, and MKP inhibitor.
Definition
ChEBI: 2,3-bis(2-hydroxyethylthio)naphthalene-1,4-dione is a member of 1,4-naphthoquinones.
Biological Activity
Potent and selective irreversible inhibitor of Cdc25 dual specificity phosphatases (K i values are 32, 96 and 40 nM for inhibition of Cdc25A, -B and -C respectively). Displays 125-180-fold selectivity over VH1-related dual-specificity phosphatase and protein tyrosine phosphatase 1b. Inhibits carcinoma cell growth and blocks G 2 /M phase transition in vitro .
Biochem/physiol Actions
Irreversible Cdc25 dual specificity phosphatase inhibitor.
storage
Desiccate at -20°C
References
1) Lazo et al. (2002), Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors; Mol. Pharmacol., 61 720 2) Melchheier et al. (2005), Quinone-induced Cdc25A inhibition causes ERK-dependent connexin phosphorylation; Biochem. Biophys. Res. Commun., 327 1016 3) Blevins et al. (2015), Small Molecule, NSC95397, inhibits the CtBP1-Protein Partner Interaction and CtBP1-Mediated Transcriptional Repression; J. Biomol. Screen., 20 663 4) Jemaa et al. (2016), Stimulation of Suicidal Erythrocyte Death by the CDC25 Inhibitor NSC-95397; Cell. Physiol. Biochem., 40 597
NSC 95397 Preparation Products And Raw materials
Raw materials
Preparation Products
NSC 95397 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35906 | 56 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4153 | 55 |