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Cefazolin sodium salt

Brand Name(s) in US
Cefazolin sodium salt
Cefazolin sodium salt structure
CAS No.
27164-46-1
Chemical Name:
Cefazolin sodium salt
Synonyms
ancef;46083;kefzol;Atirin;Azolin;totacef;zolicef;Cefazil;firmacef;gramaxin
CBNumber:
CB7403213
Molecular Formula:
C14H15N8NaO4S3
Formula Weight:
478.5
MOL File:
27164-46-1.mol

Cefazolin sodium salt Properties

Melting point:
190 °C
refractive index 
20 ° (C=10, H2O)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
H2O: 50 mg/mL, clear, colorless
form 
crystalline powder
Sensitive 
Light Sensitive
Merck 
14,1917
BRN 
3585038
Stability:
Stable, but may be heat sensitive - store in cool conditions. May discolour upon exposure to light - store in the dark. Incompatible with strong oxidizing agents.
CAS DataBase Reference
27164-46-1(CAS DataBase Reference)
FDA UNII
P380M0454Z
NCI Drug Dictionary
Ancef
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H317-H334
Precautionary statements  P261-P280-P342+P311-P280g-P284-P304+P340-P342+P311a-P501a
Hazard Codes  Xn,Xi
Risk Statements  42/43-36/37/38-20/21/22
Safety Statements  22-36/37-36-26
WGK Germany  2
RTECS  XI0390000
HS Code  29349990
Toxicity LD50 in mice, rats (mg/kg): 3.9, 3.18 i.v.; 6.2, 7.4 i.p. (Birkhead)

Cefazolin sodium salt price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C5020 Cefazolin sodium salt 89.1-110.1% 27164-46-1 100mg $81.2 2021-03-22 Buy
Sigma-Aldrich PHR2681 Cefazolin sodium salt Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 100?mg 27164-46-1 100MG $99 2021-03-22 Buy
Sigma-Aldrich C5020 Cefazolin sodium salt 89.1-110.1% 27164-46-1 1g $407 2021-03-22 Buy
TCI Chemical C2242 Cefazolin Sodium Salt >98.0%(HPLC)(T) 27164-46-1 5g $87 2021-03-22 Buy
TCI Chemical C2242 Cefazolin Sodium Salt >98.0%(HPLC)(T) 27164-46-1 25g $271 2021-03-22 Buy

Cefazolin sodium salt Chemical Properties,Uses,Production

Brand Name(s) in US

Ancef, Kefzol, and generic

Chemical Properties

White to off-white powder

Originator

Cefamedin,Fujisawa,Japan,1971

Uses

Semi-synthetic antibiotic derived from 7-amino-cepphalosporanic acid. An antibacterial

Uses

enzyme inhibitor, Gaucher's disease therapy

Uses

Semi-synthetic antibiotic derived from 7-amino-cephalosporanic acid. An antibacterial.

Definition

ChEBI: A cephalosporin organic sodium salt having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1H-tetrazol-1-ylacetyl)amino side-groups.

Manufacturing Process

7-Aminocephalosporanic acid is converted to its sodium salt and acylated with 1H-tetrazole-1-acetyl chloride. The acetoxy group is then displaced by reaction with 5-methyl-1,3,4-thiadiazole-2-thiol in buffer solution. The product acid is converted to the sodium salt by NaHCO3.

brand name

Ancef (GlaxoSmithKline); Kefzol (Lilly).

Therapeutic Function

Antibacterial

Clinical Use

Cefazolin (Ancef, Kefzol) is one of a series of semisyntheticcephalosporins in which the C-3 acetoxy function has beenreplaced by a thiol-containing heterocycle—here, 5-methyl-2-thio-1,3,4-thiadiazole. It also contains the somewhatunusual tetrazolylacetyl acylating group. Cefazolin wasreleased in 1973 as a water-soluble sodium salt. It is activeonly by parenteral administration.
Cefazolin provides higher serum levels, slower renalclearance, and a longer half-life than other first-generationcephalosporins. It is approximately 75% protein bound inplasma, a higher value than for most other cephalosporins.Early in vitro and clinical studies suggest that cefazolin ismore active against Gram-negative bacilli but less activeagainst Gram-positive cocci than either cephalothin orcephaloridine. Occurrence rates of thrombophlebitis followingintravenous injection and pain at the site of intramuscularinjection appear to be the lowest of the parenteralcephalosporins.

Veterinary Drugs and Treatments

In the United States, there are no cefazolin products approved for veterinary species but it has been used clinically in several species when an injectable, first generation cephalosporin is indicated. It is used for surgical prophylaxis, and for variety of systemic infections (including orthopedic, soft tissue, sepsis) caused by susceptible bacteria. Most commonly given every 6 – 8 hours via parenteral routes, cefazolin constant rate intravenous infusion protocols are being developed as cefazolin is a time (above MIC)-dependent antibiotic, and serum/tissue concentrations can remain above MIC.

Cefazolin sodium salt Preparation Products And Raw materials

Raw materials

Preparation Products


Cefazolin sodium salt Suppliers

Global( 281)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20892 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Guangzhou PI PI Biotech Inc
+8618371201331
020-81716319 sales@pipitech.com;87478684@qq.com China 3245 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 310 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Xi'an Kono chem co., Ltd.,
13289246953 029-86107037
info@konochemical.com CHINA 3000 58
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
faith@widelychemical.com CHINA 743 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47498 58

View Lastest Price from Cefazolin sodium salt manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-02 Cefazolin sodium salt
27164-46-1
US $235.00 / KG 1公斤 EP 10TONS Baoji Guokang Healthchem co.,ltd
2021-09-29 Cefazolin sodium salt
27164-46-1
US $0.00 / KG/Tin 10KG 95%-102%; EP 1000 KGS WUHAN FORTUNA CHEMICAL CO., LTD
2021-07-02 Cefazolin sodium salt
27164-46-1
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

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