ChemicalBook >> CAS DataBase List >>ABX-1431
ABX-1431
- CAS No.
- 1446817-84-0
- Chemical Name:
- ABX-1431
- Synonyms
- CS-2856;ABX-1431;Elcubragistat;ABX1431;ABX 1431;ABX-1431,inhibit,ABX 1431,Monoacylglycerol lipase,ABX1431,MAGL,Inhibitor;1,1,1,3,3,3-Hexafluoro-2-propyl 4-[2-(1-Pyrrolidinyl)-4-(trifluoromethyl)benzyl]piperazine-1-carboxylate;1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)piperazine-1-carboxylate;1,1,1,3,3,3-hexafluoropropan-2-yl 4-{[2-(pyrrolidin-1-yl)-4-(trifluoromethyl)phenyl]me thyl}piperazine-1-carboxylate;1-Piperazinecarboxylic acid, 4-[[2-(1-pyrrolidinyl)-4-(trifluoromethyl)phenyl]methyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester
- CBNumber:
- CB74667484
- Molecular Formula:
- C20H22F9N3O2
- Molecular Weight:
- 507.39
- MDL Number:
- MFCD31735112
- MOL File:
- 1446817-84-0.mol
Last updated:2023-06-08 09:02:56
| storage temp. | -20°C |
|---|---|
| solubility | Soluble in DMSO (>25 mg/ml) |
| form | solid |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| FDA UNII | FB39E94UXK |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
ABX-1431 price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 26023 | ABX-1431 | 1446817-84-0 | 1mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 26023 | ABX-1431 | 1446817-84-0 | 50mg | $1184 | 2024-03-01 | Buy |
| Cayman Chemical | 26023 | ABX-1431 | 1446817-84-0 | 5mg | $179 | 2024-03-01 | Buy |
| Cayman Chemical | 26023 | ABX-1431 | 1446817-84-0 | 10mg | $333 | 2024-03-01 | Buy |
| AK Scientific | 0863DV | CID71657619 | 1446817-84-0 | 10mg | $245 | 2021-12-16 | Buy |
ABX-1431 Chemical Properties,Uses,Production
Description
ABX-1431 (1446817-84-0) is a potent (IC50 = 14 nM in vitro, 2.2 nM in human PC3 cells) and very selective (>100-fold over hABHD6, >200-fold over hPLA2G7) inhibitor of monoacylglycerol lipase (MAGL).1 Active in a rat formalin pain test at 3mg/kg. Orally bioavailable and CNS penetrant.
References
1) Cisar et al. (2018), Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders; J. Med. Chem., 61 9062
ABX-1431 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 55)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4691 | 58 |
| Fujian boshi pharmaceutical technology co. LTD | 18120708884 | 393612455@qq.com | China | 255 | 58 |
CS-2856
ABX1431;ABX 1431
ABX-1431
1-Piperazinecarboxylic acid, 4-[[2-(1-pyrrolidinyl)-4-(trifluoromethyl)phenyl]methyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester
1,1,1,3,3,3-hexafluoropropan-2-yl
4-{[2-(pyrrolidin-1-yl)-4-(trifluoromethyl)phenyl]me
thyl}piperazine-1-carboxylate
1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)piperazine-1-carboxylate
ABX-1431,inhibit,ABX 1431,Monoacylglycerol lipase,ABX1431,MAGL,Inhibitor
Elcubragistat
1,1,1,3,3,3-Hexafluoro-2-propyl 4-[2-(1-Pyrrolidinyl)-4-(trifluoromethyl)benzyl]piperazine-1-carboxylate
1446817-84-0
C20H22F9N3O2