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GNE-6640

GNE-6640 structure

CAS No.: 2009273-60-1

Chemical Name:: GNE-6640

Synonyms: GNE-6640;USP7-IN-8;GNE-6776 HCl;Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl-;inhibit,USP7,Inhibitor,USP-7-IN-8,Deubiquitinase,DUBs,USP7IN8,anticancer,USP7 IN 8

CBNumber:: CB74667954

Molecular Formula:: C21H21N3O2

Molecular Weight:: 347.41

MDL Number:: MFCD34167533

MOL File:: 2009273-60-1.mol

Last updated:2023-07-12 17:02:01

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GNE-6640 Properties

Boiling point	590.1±50.0 °C(Predicted)
Density	1.210±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 83.33 mg/mL (239.86 mM; Need ultrasonic)
pka	8.20±0.15(Predicted)

GNE-6640 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0159190	USP7-IN-8 ≥98.0%	2009273-60-1	5mg	$350	2021-12-16	Buy
Biorbyt Ltd	orb573139	GNE-6640 >98%	2009273-60-1	100mg	$1133.9	2021-12-16	Buy
Biorbyt Ltd	orb573139	GNE-6640 >98%	2009273-60-1	250mg	$1802	2021-12-16	Buy
Biorbyt Ltd	orb573139	GNE-6640 >98%	2009273-60-1	1g	$3655	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0159190	5mg	$350	Buy
orb573139	100mg	$1133.9	Buy
orb573139	250mg	$1802	Buy
orb573139	1g	$3655	Buy

GNE-6640 Chemical Properties,Uses,Production

Biological Activity

USP7-IN-8 (example 81) is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM in an Ub-Rho110 assay. USP7-IN-8 shows no activity against USP47 and USP5. USP7-IN-8 has anticancer effects[1]. USP7 or HAUSP (herpesvirus-associated USP) is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. USP7 is a eubiquitinase (DUB) that controls cell proliferation by altering the stability of Mdm2, p53, PTEN and FOXO4[1].

References

[1]. Robert Blake, et al. Usp7 inhibitor compounds and methods of use. US20160272588A1.

GNE-6640 Preparation Products And Raw materials

Raw materials

Preparation Products

GNE-6640 Suppliers

Global( 13)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Shanghai Beckham Medical Technology Co., Ltd	021-13816613772 13816613772	huahero21@sina.com	China	359	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8011	62
Hangzhou Synstar pharmaceutical Technology CO.,Ltd	0571-85361029	synstar518@163.com	China	1991	58
Taizhou Crene Biotechnology Co. Ltd.	0576-88813233 13396860566	sales@pharm-intermediates.com	China	2013	58
Chunchuang (Wuhan) Technology Co., Ltd	15342225168	yutianchun2007@126.com	China	10000	58
InvivoChem	13549236410	sales@invivochem.cn	China	6713	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24018	58

Supplier	Advantage
InvivoChem	58
TargetMol Chemicals Inc.	58
Shanghai Beckham Medical Technology Co., Ltd	55
Shanghai EFE Biological Technology Co., Ltd.	58
ShangHai Biochempartner Co.,Ltd	62
Hangzhou Synstar pharmaceutical Technology CO.,Ltd	58
Taizhou Crene Biotechnology Co. Ltd.	58
Chunchuang (Wuhan) Technology Co., Ltd	58
InvivoChem	58
TargetMol Chemicals Inc.	58

GNE-6640 Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- GNE-6776 HCl USP7-IN-8 inhibit,USP7,Inhibitor,USP-7-IN-8,Deubiquitinase,DUBs,USP7IN8,anticancer,USP7 IN 8 2009273-60-1