Anti-HOIP (RNF31) Antibody, clone 1CB2

CAS No.
Chemical Name:
Anti-HOIP (RNF31) Antibody, clone 1CB2
Synonyms
Anti-HOIP (RNF31) Antibody, clone 1CB2
CBNumber:
CB74816187
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file

Anti-HOIP (RNF31) Antibody, clone 1CB2 price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich MABE1122 Anti-HOIP (RNF31) Antibody, clone 1CB2 clone 1CB2, from mouse 100μg $416 2024-03-01 Buy
Product number Packaging Price Buy
MABE1122 100μg $416 Buy

Anti-HOIP (RNF31) Antibody, clone 1CB2 Chemical Properties,Uses,Production

Uses

Detect HOIP using this mouse monoclonal Anti-HOIP (RNF31), clone 1CB2 Antibody, Cat. No. MABE1122, validated for use in Immunohistochemistry (Paraffin) and Western Blotting.

General Description

E3 ubiquitin-protein ligase RNF31 (UniProt Q96EP0; also known as HOIL-1-interacting protein, HOIP, RING finger protein 31, Zinc in-between-RING-finger ubiquitin-associated domain protein) is encoded by the RNF31 (also known as ZIBRA) gene (Gene ID 55072) in human. HOIP is a RING-between-RING (RBR) family E3 ubiquitin ligase and the only enzyme known to catalyze linear-ubiquitin-chain conjugation. HOIP functions as the primary E3 Ub ligase of the immune signaling regulatory complex LUBAC (linear-ubiquitin-chain assembly complex) composed of heme-oxidized IRP2 ubiquitin ligase-1 (HOIL-1L), HOIP, and SHANK-associated RH domain interactor (Sharpin). RBR ligases often exist in autoinhibited conformations and require protein-protein interactions or posttranslational modifications to induce a conformational change for activation. Disruption of HOIP and HOIL-1L interaction in activated B cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) induces DLBCL death as a result of decreased NF-κB activation due to HOIP inactivation. On the other hand, HOIP K1056R mutant is resistant to inactivation by TLR4 stimulation-induced HOIP K1056 ubiquitination. Human HOIP is a 1072-a.a. protein that contains a polyUb-binding region (a.a. 1-485), a ubiquitin-associated or UBA domain (a.a. 564-615) that mediates HOIL-1L/RBCK1 interactioin, and a C-terminal linear-ubiquitin-chain-determining domain or LDD domain (a.a. 910-1072). In addition, HOIP conatins three RanBP2-type Zinc fingers (a.a. 299-329, 350-379, 409-438), two RING-type Zinc fingers (a.a. 699-747 and 860-909), and one IBR-type Zinc fingers (a.a. 779-841).

Anti-HOIP (RNF31) Antibody, clone 1CB2 Preparation Products And Raw materials

Raw materials

Preparation Products

Anti-HOIP (RNF31) Antibody, clone 1CB2 Suppliers

Global( 2)Suppliers
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Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
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Anti-HOIP (RNF31) Antibody, clone 1CB2