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Cdk1 Inhibitor IV, RO-3306 - Calbiochem

Cdk1 Inhibitor IV, RO-3306 - Calbiochem Structure
Cdk1 Inhibitor IV, RO-3306 - Calbiochem structure
CAS No.
Chemical Name:
Cdk1 Inhibitor IV, RO-3306 - Calbiochem
Synonyms
Cdk1 Inhibitor IV, RO-3306 - Calbiochem
CBNumber:
CB74816985
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file
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Cdk1 Inhibitor IV, RO-3306 - Calbiochem price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 217699 Cdk1 Inhibitor IV, RO-3306 - Calbiochem 5mg $318 2024-03-01 Buy
Product number Packaging Price Buy
217699 5mg $318 Buy

Cdk1 Inhibitor IV, RO-3306 - Calbiochem Chemical Properties,Uses,Production

General Description

A cell-permeable quinolinyl thiazolinone compound that acts as a potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). It affects Cdk2/E, PKCδ, and SGK only at much higher concentrations (Ki = 340, 318, and 497 nM, respectively), and shows little effect against Cdk4/D and six other commonly studied kinases (Ki ≥ 2 μM). Short-term treatment for up to 20 hrs results in fully reversible G2/M cell cycle arrest, while prolonged treament (>48 hrs) results in apoptotic cell death in proliferating cancer cells, but not in nontumorigenic epithelial cell lines. Also available as a 10 mM solution in DMSO (Cat. No. 217721).

Biochem/physiol Actions

Cell permeable: yes

Cdk1 Inhibitor IV, RO-3306 - Calbiochem Preparation Products And Raw materials

Raw materials

Preparation Products

Cdk1 Inhibitor IV, RO-3306 - Calbiochem Suppliers

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Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
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Cdk1 Inhibitor IV, RO-3306 - Calbiochem