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MC-VC-PABC-DNA31

MC-VC-PABC-DNA31 Structure
MC-VC-PABC-DNA31 structure
CAS No.
1639352-03-6
Chemical Name:
MC-VC-PABC-DNA31
Synonyms
MC-VC-PABC-DNA31;Rifamycin VIII, 1',4-didehydro-5'-[4-[[[[4-[[N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]amino]-1-piperidinyl]-1,4-dihydro-3'-hydroxy-1-oxo-
CBNumber:
CB75540384
Molecular Formula:
C77H96N10O21
Molecular Weight:
1497.64
MDL Number:
MFCD32197308
MOL File:
1639352-03-6.mol
Last updated:2025-04-18 09:52:43
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MC-VC-PABC-DNA31 Properties

Density 1.42±0.1 g/cm3(Predicted)
pka 4.28±0.70(Predicted)
form Solid
color Light blue to blue

MC-VC-PABC-DNA31 Chemical Properties,Uses,Production

Uses

MC-VC-PABC-DNA31 is a agent-linker conjugate for ADC with potent antitumor activity by using DNA31 (a potent RNA polymerase inhibitor), linked via the ADC linker MC-VC-PABC.

IC 50

Traditional Cytotoxic Agents

References

[1] Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119. DOI:10.1038/nchem.2635

MC-VC-PABC-DNA31 Preparation Products And Raw materials

Raw materials

Preparation Products

MC-VC-PABC-DNA31 Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32435 58
ChemExpress 		+86-19370970350 +86-021-58950125 info@chemexpress.com China 787 58
Henan Rane Chemical Co., Ltd. 		+8618738066252 info@ranechem.com China 3034 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9729 58
Shanghai Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 819 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 021-59167510 18117107507 vip@med-life.cn China 5002 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29579 58
Adooq Bioscience LLC 400-025-6535 sales@adooq.cn China 6215 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
ChemExpress 		58
Henan Rane Chemical Co., Ltd. 		58
Fan De(Beijing) Biotechnology Co., Ltd. 58
Shanghai Haoyuan Chemexpress Co., Ltd. 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 58
TargetMol Chemicals Inc. 58
Adooq Bioscience LLC 58
MC-VC-PABC-DNA31 Rifamycin VIII, 1',4-didehydro-5'-[4-[[[[4-[[N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]amino]-1-piperidinyl]-1,4-dihydro-3'-hydroxy-1-oxo- 1639352-03-6