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H-TRP-GLU-OH

H-TRP-GLU-OH structure

CAS No.: 36099-95-3

Chemical Name:: H-TRP-GLU-OH

Synonyms: WE;G3335;TRP-GLU;L-TRP-GLU;H-TRP-GLU-OH;TRP-GLU CRYSTALLINE;PPARγ Antagonist III,G3335;L-TRYPTOPHYL-L-GLUTAMIC ACID;L-Glutamic acid, L-tryptophyl-;PPARγ Antagonist III, G3335 - CAS 36099-95-3 - Calbiochem

CBNumber:: CB7745599

Molecular Formula:: C16H19N3O5

Molecular Weight:: 333.34

MDL Number:: MFCD00037964

MOL File:: 36099-95-3.mol

Last updated:2023-07-12 16:57:08

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H-TRP-GLU-OH Properties

Melting point	>163°C(dec.)
Boiling point	720.7±60.0 °C(Predicted)
Density	1.428±0.06 g/cm3(Predicted)
storage temp.	-15°C
solubility	Chloroform (Slightly), DMSO (Slightly)
form	White solid
pka	3.02±0.10(Predicted)
color	white to off-white
Sensitive	Light Sensitive

H-TRP-GLU-OH price More Price(15)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML1449	G3335 ≥98% (HPLC)	36099-95-3	50mg	$118	2024-03-01	Buy
Sigma-Aldrich	516566	PPARγ Antagonist III, G3335	36099-95-3	50mg	$159	2024-03-01	Buy
Alfa Aesar	J64528	G3335	36099-95-3	50mg	$122	2023-06-20	Buy
Alfa Aesar	J64528	G3335	36099-95-3	100mg	$208	2023-06-20	Buy
Cayman Chemical	17593	G3335 ≥98%	36099-95-3	10mg	$32	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML1449	50mg	$118	Buy
516566	50mg	$159	Buy
J64528	50mg	$122	Buy
J64528	100mg	$208	Buy
17593	10mg	$32	Buy

H-TRP-GLU-OH Chemical Properties,Uses,Production

Uses

A cell-permeable dipeptide that acts as a selective and reversible peroxisome proliferator-activated receptor antagonist

Definition

ChEBI: Trp-Glu is a dipeptide formed from L-tryptophan and L-glutamic acid residues. It has a role as a metabolite.

Biological Activity

kd = 8.34 μmg3335 is a pparγ antagonist.the peroxisome proliferator-activated receptor gamma (ppargamma) is a key therapeutic drug target for several conditions, such as inflammation, diabetes, hypertension, dyslipidemia, and cancer.

in vitro

biacore 3000 study based on the surface plasmon resonance technique found that g3335 exhibited a highly specific binding affinity against ppargamma and was able to block rosiglitazone, a potent ppargamma agonist, in the stimulation of the interaction between the ppargamma ligand-binding domain (lbd) and rxralpha-lbd. moreover, the yeast two-hybrid assays indicated that g3335 had strong antagonistic activity in perturbing rosiglitazone in the promotion of the ppargamma-lbd-cbp interaction. in addition, g3335 could competitively bind to ppargamma against 0.1 microm rosiglitazone to repress reporter-gene expression [1].

in vivo

in a previous study, the effect of rosiglitazone was examined on spinal cord injury (sci) in rats. the animals were randomly divided into vehicle group, rosiglitazone treated group, and g3335 treated group. locomotor function recovery was evaluated. results showed that compared with the vehicle groups, the rosiglitazone could significantly ameliorate locomotor recovery, reduce nf-κb expression, and increase the proliferation of endogenous npcs. in addition, when the ppar-γ antagonist g3335 was applied, such effects were abolished [2].

References

[1] ye, f. ,zhang, z.s.,luo, h.b., et al. the dipeptide h-trp-glu-oh shows highly antagonistic activity against pparγ: bioassay with molecular modeling simulation. chembiochem 7, 74-82 (2006).
[2] meng, q. q.,liang, x.j.,wang, p., et al. rosiglitazone enhances the proliferation of neural progenitor cells and inhibits inflammation response after spinal cord injury. neuroscience letters 503, 191-195 (2011).

H-TRP-GLU-OH Preparation Products And Raw materials

Raw materials

Preparation Products

H-TRP-GLU-OH Suppliers

Global( 84)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19915	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
Nanjing TGpeptide	+86-13347807150 +86-13347807150	support@tgpeptide.com	China	3279	58
Zhejiang Hangyu API Co., Ltd	+8617531972939	anna@api-made.com	China	2944	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42982	64
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15421	60
Dalian Meilun Biotech Co., Ltd.	0411-62910999 13889544652	sales@meilune.com	China	4668	58

Supplier	Advantage
Nextpeptide Inc	58
LEAP CHEM CO., LTD.	58
Nanjing TGpeptide	58
Zhejiang Hangyu API Co., Ltd	58
Aladdin Scientific	58
GL Biochem (Shanghai) Ltd	64
VDM Biochemicals	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky (shanghai) International Co.,Ltd	60
Dalian Meilun Biotech Co., Ltd.	58

H-TRP-GLU-OH Spectrum

H-TRP-GLU-OH(36099-95-3)¹³CNMR

36099-95-3(H-TRP-GLU-OH)Related Search:

Trp-Glu-OH H-GLN-TRP-GLU-OH H-TRP-ALA-OH H-DL-TRP-NH2 HCL H-ILE-ALA-ALA-ARG-ILE-VAL-GLU-LEU-LEU-GLY-ARG-ARG-GLY-TRP-GLU-OH

GLYCYL-L-GLUTAMIC ACID INDOLE-3-PROPIONAMIDE H-TRP-GLU-OH GLYCYL-4-AMINO-N-BUTYRIC ACID L-Glutamic acid

H-ALA-GLU-OH N-Acetyl-L-glutamic acid H-TRP-GLY-OH

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TRP-GLU H-TRP-GLU-OH L-TRYPTOPHYL-L-GLUTAMIC ACID L-TRP-GLU TRP-GLU CRYSTALLINE G3335 PPARγ Antagonist III,G3335 WE PPARγ Antagonist III, G3335 - CAS 36099-95-3 - Calbiochem L-Glutamic acid, L-tryptophyl- 36099-95-3 A cell-permeable dipeptide that acts as a selective and reversible PPAR./ antagonist Amino Acid Derivatives