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ChemicalBook >> CAS DataBase List >>1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-[2-[4-[3-[[4-[[[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]amino]carbonyl]-6-quinolinyl]methylamino]propyl]-1-piperazinyl]-2-oxoethyl]-

1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-[2-[4-[3-[[4-[[[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]amino]carbonyl]-6-quinolinyl]methylamino]propyl]-1-piperazinyl]-2-oxoethyl]-

1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-[2-[4-[3-[[4-[[[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]amino]carbonyl]-6-quinolinyl]methylamino]propyl]-1-piperazinyl]-2-oxoethyl]- Structure
1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-[2-[4-[3-[[4-[[[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]amino]carbonyl]-6-quinolinyl]methylamino]propyl]-1-piperazinyl]-2-oxoethyl]- structure
CAS No.
2374782-04-2
Chemical Name:
1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-[2-[4-[3-[[4-[[[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]amino]carbonyl]-6-quinolinyl]methylamino]propyl]-1-piperazinyl]-2-oxoethyl]-
Synonyms
FAPI-46 trifluoroacetate;1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-[2-[4-[3-[[4-[[[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]amino]carbonyl]-6-quinolinyl]methylamino]propyl]-1-piperazinyl]-2-oxoethyl]-;(S)-2,2',2''-(10-(2-(4-(3-((4-((2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamoyl)quinolin-6-yl)(methyl)amino)propyl)piperazin-1-yl)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid;(S)-2,2',2''-(10-(2-(4-(3-((4-((2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamoyl)quinolin-6-yl)(methyl)amino)propyl)piperazin-1-yl)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid
CBNumber:
CB78096093
Molecular Formula:
C41H57F2N11O9
Molecular Weight:
885.96
MDL Number:
MOL File:
2374782-04-2.mol
Last updated:2025-07-04 15:27:35
Request For Quotation

1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-[2-[4-[3-[[4-[[[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]amino]carbonyl]-6-quinolinyl]methylamino]propyl]-1-piperazinyl]-2-oxoethyl]- Properties

Boiling point 1148.7±65.0 °C(Predicted)
Density 1.45±0.1 g/cm3(Predicted)
storage temp. 4°C, away from moisture
solubility DMSO : 100 mg/mL (112.87 mM; Need ultrasonic)
pka 1.83±0.10(Predicted)
form Solid
color Light yellow to yellow
InChIKey SDBGUEFOSXNKBX-WOGWZMQPNA-N
SMILES C(C1=CC=NC2C=CC(N(C)CCCN3CCN(C(=O)CN4CCN(CCN(CC(=O)O)CCN(CC(=O)O)CC4)CC(=O)O)CC3)=CC1=2)(=O)NCC(N1CC(F)(F)C[C@H]1C#N)=O |&1:59,r|
FDA UNII 59QC5DY68A

1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-[2-[4-[3-[[4-[[[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]amino]carbonyl]-6-quinolinyl]methylamino]propyl]-1-piperazinyl]-2-oxoethyl]- Chemical Properties,Uses,Production

Uses

FAPI-46 is a quinoline-based fibroblast activation protein (FAP)-targeted tracer. Use radioactivity FAPI-46 labeled with 68Ga or 177Lu can be used for tumor imaging in a variety of cancers and has higher tumor uptake rates and longer tumor accumulation[1][2].

in vivo

FAPI-46 (i.v.) shows improved ratios of tumor to liver, kidney, and brain uptake, resulting in an enhanced image contrast for PET imaging[1].

References

[1] Loktev A, et, al. Development of Fibroblast Activation Protein-Targeted Radiotracers with Improved Tumor Retention. J Nucl Med. 2019 Oct;60(10):1421-1429. DOI:10.2967/jnumed.118.224469
[2] Moon ES, et, al. Targeting fibroblast activation protein (FAP): next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA 5m chelators. EJNMMI Radiopharm Chem. 2020 Jul 29;5(1):19. DOI:10.1186/s41181-020-00102-z

1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-[2-[4-[3-[[4-[[[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]amino]carbonyl]-6-quinolinyl]methylamino]propyl]-1-piperazinyl]-2-oxoethyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-[2-[4-[3-[[4-[[[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]amino]carbonyl]-6-quinolinyl]methylamino]propyl]-1-piperazinyl]-2-oxoethyl]- Suppliers

Global( 20)Suppliers
Supplier Tel Email Country ProdList Advantage
Xian confluore Biological Technology Co., Ltd. 		+86-15680926068 1924344760@confluore.cn China 2997 58
Aladdin Scientific 		tp@aladdinsci.com United States 52923 58
ComMedX (Computational Medicine Beijing Co., Ltd.) 		+86-18519000250 +86-18519000250 zhanghu@commedx.com China 258 58
Nanchang Tianzhen Biotechnology Co., Ltd 13173652190 pomy@tanzhenbio.com China 2395 58
Hangzhou Beiputai Biopharmaceutical Co., Ltd 0571-85350119 15888826472 bptsales@163.com China 3834 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4759 55
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 9118 58
Xi'an Confluore Biological Technology Co., Ltd. +86-156-80926068 +86-15680926068 1924344760@qq.com China 4952 58
Hangzhou Peptidego Biotech Co.,Ltd. 0571-87213919 Eric@peptidego.com China 7408 58
Nanjing Sincerity Chemical Co. Ltd. 25-17366221-609 13245250309 hp@njsincerity.com China 301 58
Supplier Advantage
Xian confluore Biological Technology Co., Ltd. 		58
Aladdin Scientific 		58
ComMedX (Computational Medicine Beijing Co., Ltd.) 		58
Nanchang Tianzhen Biotechnology Co., Ltd 58
Hangzhou Beiputai Biopharmaceutical Co., Ltd 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai Chaolan Chemical Technology Center 58
Xi'an Confluore Biological Technology Co., Ltd. 58
Hangzhou Peptidego Biotech Co.,Ltd. 58
Nanjing Sincerity Chemical Co. Ltd. 58

View Lastest Price from 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-[2-[4-[3-[[4-[[[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]amino]carbonyl]-6-quinolinyl]methylamino]propyl]-1-piperazinyl]-2-oxoethyl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
FAPI-46 pictures 2025-06-07 FAPI-46
2374782-04-2
 US $0.00 / mg 10mg >95.00% 10mg Xian confluore Biological Technology Co., Ltd.
  • FAPI-46 pictures
  • FAPI-46
    2374782-04-2
  • US $0.00 / mg
  • >95.00%
  • Xian confluore Biological Technology Co., Ltd.
(S)-2,2',2''-(10-(2-(4-(3-((4-((2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamoyl)quinolin-6-yl)(methyl)amino)propyl)piperazin-1-yl)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid FAPI-46 trifluoroacetate (S)-2,2',2''-(10-(2-(4-(3-((4-((2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamoyl)quinolin-6-yl)(methyl)amino)propyl)piperazin-1-yl)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-[2-[4-[3-[[4-[[[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]amino]carbonyl]-6-quinolinyl]methylamino]propyl]-1-piperazinyl]-2-oxoethyl]- 2374782-04-2 C41H57F2N11O9