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ChemicalBook >> CAS DataBase List >>5H-Indeno[5,6-b]furan-3-acetamide, 6,7-dihydro-N-(5-methyl-2-thiazolyl)-

5H-Indeno[5,6-b]furan-3-acetamide, 6,7-dihydro-N-(5-methyl-2-thiazolyl)-

5H-Indeno[5,6-b]furan-3-acetamide, 6,7-dihydro-N-(5-methyl-2-thiazolyl)- Structure
5H-Indeno[5,6-b]furan-3-acetamide, 6,7-dihydro-N-(5-methyl-2-thiazolyl)- structure
CAS No.
790245-61-3
Chemical Name:
5H-Indeno[5,6-b]furan-3-acetamide, 6,7-dihydro-N-(5-methyl-2-thiazolyl)-
Synonyms
NCT02;5H-Indeno[5,6-b]furan-3-acetamide, 6,7-dihydro-N-(5-methyl-2-thiazolyl)-;2-{5h,6h,7h-indeno[5,6-b]furan-3-yl}-n-(5-methyl-1,3-thiazol-2-yl)acetamide
CBNumber:
CB79830676
Molecular Formula:
C17H16N2O2S
Molecular Weight:
312.39
MDL Number:
MOL File:
790245-61-3.mol
Last updated:2023-06-30 15:45:59
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5H-Indeno[5,6-b]furan-3-acetamide, 6,7-dihydro-N-(5-methyl-2-thiazolyl)- Properties

Density 1.368±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble to 100 mM in DMSO
pka 8.95±0.50(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362

5H-Indeno[5,6-b]furan-3-acetamide, 6,7-dihydro-N-(5-methyl-2-thiazolyl)- Chemical Properties,Uses,Production

Biological Activity

NCT02 is a cyclin K degrader. NCT02 induces ubiquitination of cyclin K (CCNK) and proteasomal degradation of CCNK and its complex partner CDK12. NCT02 has the potential for the research of metastatic colorectal cancer (CRC)[1].

storage

Store at -20°C

References

[1]. Dieter SM, et al. Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer. Cell Rep. 2021;36(3):109394.

5H-Indeno[5,6-b]furan-3-acetamide, 6,7-dihydro-N-(5-methyl-2-thiazolyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

5H-Indeno[5,6-b]furan-3-acetamide, 6,7-dihydro-N-(5-methyl-2-thiazolyl)- Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32686 60
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24018 58
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 17801761073 Gsiyu@solarbio.com China 50471 58
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 sales@tybiochem.com China 5141 58
https://hanhongsci.com/ 021-54306202 18917919676 info@hanhongsci.com China 29989 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 021-59167510 18117107507 vip@med-life.cn China 5019 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9180 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Aladdin Scientific 		58
TargetMol Chemicals Inc. 58
Beijing Solarbio Science & Tecnology Co., Ltd. 58
Nanjing Tengyi Biotechnology Co., Ltd 58
https://hanhongsci.com/ 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 58
RD International Technology Co., Limited 58
5H-Indeno[5,6-b]furan-3-acetamide, 6,7-dihydro-N-(5-methyl-2-thiazolyl)- 2-{5h,6h,7h-indeno[5,6-b]furan-3-yl}-n-(5-methyl-1,3-thiazol-2-yl)acetamide NCT02 790245-61-3