ChemicalBook >> CAS DataBase List >>Ethanesulfonamide, N-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2H-benzofuro[2,3-a]quinolizin-2-yl]-2-hydroxy-N-methyl-

Ethanesulfonamide, N-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2H-benzofuro[2,3-a]quinolizin-2-yl]-2-hydroxy-N-methyl-

Ethanesulfonamide, N-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2H-benzofuro[2,3-a]quinolizin-2-yl]-2-hydroxy-N-methyl- structure

CAS No.: 98719-20-1

Chemical Name:: Ethanesulfonamide, N-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2H-benzofuro[2,3-a]quinolizin-2-yl]-2-hydroxy-N-methyl-

Synonyms: Ethanesulfonamide, N-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2H-benzofuro[2,3-a]quinolizin-2-yl]-2-hydroxy-N-methyl-

CBNumber:: CB79946382

Molecular Formula:: C18H24N2O4S

Molecular Weight:: 364.46

MDL Number:

MOL File:: 98719-20-1.mol

Last updated:2025-04-17 18:22:24

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Ethanesulfonamide, N-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2H-benzofuro[2,3-a]quinolizin-2-yl]-2-hydroxy-N-methyl- Properties

Boiling point	541.9±60.0 °C(Predicted)
Density	1.38±0.1 g/cm3(Predicted)
pka	14.04±0.10(Predicted)

Ethanesulfonamide, N-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2H-benzofuro[2,3-a]quinolizin-2-yl]-2-hydroxy-N-methyl- Chemical Properties,Uses,Production

Uses

L-654284 is an α2-adrenergic receptor antagonist with significant selectivity. L-654284 competes with the binding of 3H-clonidine and 3H-rauwolscine in vitro and shows Ki values of 0.8 nM and 1.1 nM, respectively. L-654284 can block the protrusion effect of clonidine in isolated vas deferens in rats, with a pA2 value of 9.1. L-654284 exhibits remarkable selectivity for α2 and α1 adrenergic receptors, and exhibits a Ki of 110 nM in inhibiting 3H-prazosin binding. L-654284 can significantly increase the turnover rate of norepinephrine in rat cerebral cortex in vivo, showing α2-adrenergic receptor blocking activity in the central nervous system[1].

References

[1] L-654,284 a new potent and selective alpha 2-adrenoceptor antagonist

Ethanesulfonamide, N-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2H-benzofuro[2,3-a]quinolizin-2-yl]-2-hydroxy-N-methyl- Preparation Products And Raw materials

Raw materials

Preparation Products

Ethanesulfonamide, N-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2H-benzofuro[2,3-a]quinolizin-2-yl]-2-hydroxy-N-methyl- Suppliers

Global( 1)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29641	58

Supplier	Advantage
TargetMol Chemicals Inc.	58

Ethanesulfonamide, N-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2H-benzofuro[2,3-a]quinolizin-2-yl]-2-hydroxy-N-methyl- 98719-20-1