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ChemicalBook >> CAS DataBase List >>Methanone, [4-hydroxy-2-(2-hydroxyphenyl)-5-thiazolyl]-2-isoxazolidinyl-

Methanone, [4-hydroxy-2-(2-hydroxyphenyl)-5-thiazolyl]-2-isoxazolidinyl-

Methanone, [4-hydroxy-2-(2-hydroxyphenyl)-5-thiazolyl]-2-isoxazolidinyl- Structure
Methanone, [4-hydroxy-2-(2-hydroxyphenyl)-5-thiazolyl]-2-isoxazolidinyl- structure
CAS No.
2102179-29-1
Chemical Name:
Methanone, [4-hydroxy-2-(2-hydroxyphenyl)-5-thiazolyl]-2-isoxazolidinyl-
Synonyms
TRPM8 antagonist 3;Methanone, [4-hydroxy-2-(2-hydroxyphenyl)-5-thiazolyl]-2-isoxazolidinyl-;TRPM8 antagonist 3,TRP Channel,Transient receptor potential channels,inhibit,TRPM-8 antagonist 3,Inhibitor
CBNumber:
CB79974802
Molecular Formula:
C13H12N2O4S
Molecular Weight:
292.31
MDL Number:
MOL File:
2102179-29-1.mol
Last updated:2023-05-21 10:59:17
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Methanone, [4-hydroxy-2-(2-hydroxyphenyl)-5-thiazolyl]-2-isoxazolidinyl- Properties

Boiling point 579.7±60.0 °C(Predicted)
Density 1.517±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
pka 6.08±0.45(Predicted)

Methanone, [4-hydroxy-2-(2-hydroxyphenyl)-5-thiazolyl]-2-isoxazolidinyl- Chemical Properties,Uses,Production

Biological Activity

TRPM8 antagonist 3 is a novel TRPM8 blocker with an IC50 value of 11 nM.

References

[1]. Bianchini G, et al. Discovery of Novel TRPM8 Blockers Suitable for the Treatment of Somatic and Ocular Painful Conditions: A Journey through pKa and LogD Modulation. J Med Chem. 2021 Nov 25;64(22):16820-16837.

Methanone, [4-hydroxy-2-(2-hydroxyphenyl)-5-thiazolyl]-2-isoxazolidinyl- Preparation Products And Raw materials

Raw materials

Preparation Products

Methanone, [4-hydroxy-2-(2-hydroxyphenyl)-5-thiazolyl]-2-isoxazolidinyl- Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32715 60
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 9854 58
Shanghai SuperLan Chemcial Technique Centre 021-2022843681 15618226720 chaolaichem@foxmail.com China 9242 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24017 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9154 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050 cindy.huang@synzest.com China 12007 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Shanghai Chaolan Chemical Technology Center 58
Shanghai SuperLan Chemcial Technique Centre 58
TargetMol Chemicals Inc. 58
RD International Technology Co., Limited 58
Nanjing Shizhou Biology Technology Co.,Ltd 58
Methanone, [4-hydroxy-2-(2-hydroxyphenyl)-5-thiazolyl]-2-isoxazolidinyl- TRPM8 antagonist 3 TRPM8 antagonist 3,TRP Channel,Transient receptor potential channels,inhibit,TRPM-8 antagonist 3,Inhibitor 2102179-29-1