4-Piperidinone, 3-[(4-hydroxyphenyl)methylene]-5-(1H-indol-3-ylmethylene)-1-methyl-, (3E,5E)-
![4-Piperidinone, 3-[(4-hydroxyphenyl)methylene]-5-(1H-indol-3-ylmethylene)-1-methyl-, (3E,5E)- Structure](CAS/20210305/GIF/1370032-20-4.gif)
- CAS No.
- 1370032-20-4
- Chemical Name:
- 4-Piperidinone, 3-[(4-hydroxyphenyl)methylene]-5-(1H-indol-3-ylmethylene)-1-methyl-, (3E,5E)-
- Synonyms
- CUR5g;(E)-3-((1H-indol-3-yl)methylene)-5-((E)-4-hydroxybenzylidene)-1-methylpiperidin-4-one;4-Piperidinone, 3-[(4-hydroxyphenyl)methylene]-5-(1H-indol-3-ylmethylene)-1-methyl-, (3E,5E)-
- CBNumber:
- CB812468517
- Molecular Formula:
- C22H20N2O2
- Molecular Weight:
- 344.41
- MDL Number:
- MOL File:
- 1370032-20-4.mol
4-Piperidinone, 3-[(4-hydroxyphenyl)methylene]-5-(1H-indol-3-ylmethylene)-1-methyl-, (3E,5E)- Chemical Properties,Uses,Production
Uses
CUR5g is a potent autophagy inhibitor. CUR5g selectively inhibits autophagosome degradation in cancer cells by blocking autophagosome-lysosome fusion. CUR5g blocks the recruitment of STX17 to autophagosomes via a UVRAG-dependent mechanism, resulting in the inability of autophagosomes to fuse with lysosomes. CUR5g improves the anticancer effect of Cisplatin.html" class="link-product" target="_blank">Cisplatin (HY-17394) against A549 cells both in vitro and in vivo[1].
in vivo
CUR5g (40 mg/kg, Injected via caudal vein, once every 2 days for up to 15 days) exhibits synergistic anticancer effects with Cisplatin.html" class="link-product" target="_blank">Cisplatin (HY-17394) (1 mg/kg) and inhibits autophagic flux in vivo[1].
| Animal Model: | BALB/c nude mice (4-week-old, A549 cells were subcutaneously injected into the right scapula of each nude mouse)[1] |
| Dosage: | 40?mg/kg, CUR5g (40 mg/kg) and Cisplatin (1 mg/kg) |
| Administration: | Injected via caudal vein, once every 2 days for up to 15 days |
| Result: | Retarded the growth of xenografted tumors, whereas the combination treatment with Cisplatin almost completely inhibited tumor growth. Promoted the cisplatin sensitivity of A549 cells by inhibiting autophagic flux. |
References
[1] Chen J, et al. CUR5g, a novel autophagy inhibitor, exhibits potent synergistic anticancer effects with cisplatin against non-small-cell lung cancer. Cell Death Discov. 2022 Oct 31;8(1):435. DOI:10.1038/s41420-022-01217-9
4-Piperidinone, 3-[(4-hydroxyphenyl)methylene]-5-(1H-indol-3-ylmethylene)-1-methyl-, (3E,5E)- Preparation Products And Raw materials
Raw materials
Preparation Products
4-Piperidinone, 3-[(4-hydroxyphenyl)methylene]-5-(1H-indol-3-ylmethylene)-1-methyl-, (3E,5E)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 8011 | 55 |
| Changzhou Chenhong Biotechnology Co., Ltd. | +86-0519-85788828 +86-13775037613 | sales@chemrenpharm.com | China | 3934 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 4809 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29257 | 58 |
| Guangzhou Weisheng Biotechnology Co., Ltd. | 17765667235 | CHINA | 129 | 58 |
