CONESSINE
- CAS No.
- 546-06-5
- Chemical Name:
- CONESSINE
- Synonyms
- NERIINE;NERVINE;CONESSIN;Konessin;CONESSINE;WRIGHTINE;ROQUESSINE;ROGUESSINE;NSC 119994;Conessinum
- CBNumber:
- CB8139148
- Molecular Formula:
- C24H40N2
- Molecular Weight:
- 356.59
- MDL Number:
- MFCD00016752
- MOL File:
- 546-06-5.mol
- MSDS File:
- SDS
| Melting point | 126-127°C |
|---|---|
| alpha | D20 +25.3° (c = 0.7 in abs alc) |
| Boiling point | 479.38°C (rough estimate) |
| Density | 0.9492 (rough estimate) |
| refractive index | 1.5640 (estimate) |
| storage temp. | Store at RT |
| solubility | ethanol: ≥2mg/mL |
| form | powder |
| pka | 10.20±0.70(Predicted) |
| color | white to tan |
| LogP | 6.060 (est) |
| FDA UNII | EZ38J9BBDF |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GK7621000 | |||||||||
| HS Code | 2939799090 | |||||||||
| NFPA 704 |
|
CONESSINE price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0095 | Conessine ≥97% (HPLC) | 546-06-5 | 10mg | $53.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0095 | Conessine ≥97% (HPLC) | 546-06-5 | 50mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 11700 | Conessine ≥98% | 546-06-5 | 50mg | $120 | 2024-03-01 | Buy |
| Cayman Chemical | 11700 | Conessine ≥98% | 546-06-5 | 100mg | $228 | 2024-03-01 | Buy |
| Cayman Chemical | 11700 | Conessine ≥98% | 546-06-5 | 250mg | $504 | 2024-03-01 | Buy |
CONESSINE Chemical Properties,Uses,Production
Description
Conessine is a naturally occurring steroid alkaloid found in a number of plant species from the Apocynaceae family, which have been used in traditional herbal medicine as a treatment for amoebic dysentery. In a radioligand-
Uses
antiamebic, antibacterial, antineoplastic, anesthetic (local)
Uses
Conessine is a steroidal dibasic alkaloid with a rigid steroid-based skeleton. Conessine is a potent and selective histamine H3 receptor antagonist.
Definition
ChEBI: A steroid alkaloid that is con-5-enine substituted by a N,N-dimethylamino group at position 3. It has been isolated from the plant species of the family Apocynaceae.
Biological Activity
Potent and selective histamine H 3 receptor antagonist (pK i values are 7.61 and 8.27 at rat and human H 3 receptors respectively). A steroidal alkaloid that displays in vitro antiplasmodial activity (IC 50 = 1.04 μ M). Also has high affinity for α 2C adrenoceptors (pK i = 7.98).
Purification Methods
It crystallises from acetone, sublimes at 95o/0.01mm and boils at 0.1mm with bath temperature at 220o. The dihydrochloride has m >340o (browns at 235o and decomposes at 338-240o) and has [] D +9.3o (c 2, H2O). [Marshall & Johnson J Am Chem Soc 84 1458 1962, Beilstein 22 III/IV 4382.]
CONESSINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9641 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12382 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | peter68@ptchemgroup.com | China | 35453 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
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