EMD 53998
- CAS No.
- 120223-04-3
- Chemical Name:
- EMD 53998
- Synonyms
- EMD 53998;5-[1-(3,4-Dimethoxybenzoyl)-1,2,3,4-tetrahydro-6-quinolinyl]-6-methyl-3,6-dihydro-2H-1,3,4-thiadiazin-2-one;5-[[1-(3,4-Dimethoxybenzoyl)-1,2,3,4-tetrahydroquinolin]6-yl]-3,6-dihydro-6-methyl-2H-1,3,4-thiadiazin-2-one;2H-1,3,4-Thiadiazin-2-one, 5-[1-(3,4-dimethoxybenzoyl)-1,2,3,4-tetrahydro-6-quinolinyl]-3,6-dihydro-6-methyl-
- CBNumber:
- CB81394245
- Molecular Formula:
- C22H23N3O4S
- Molecular Weight:
- 425.5
- MDL Number:
- MFCD00884699
- MOL File:
- 120223-04-3.mol
| Density | 1.36±0.1 g/cm3(Predicted) |
|---|---|
| pka | 10.54±0.60(Predicted) |
| form | Solid |
| color | White to off-white |
| FDA UNII | 3L67D8JK8X |
EMD 53998 Chemical Properties,Uses,Production
Uses
EMD 53998 is a cardiotonic agent that increases myocardial contractility as an inhibitor for phosphodiesterase III (PDE III) and a calcium sensitizer. EMD 53998 increases myocardial contractility, reduces energy consumption and the risk of inducing arrhythmias[1].
IC 50
PDE3
References
[1] Lues I, et al., The two mechanisms of action of racemic cardiotonic EMD 53998, calcium sensitization and phosphodiesterase inhibition, reside in different enantiomers. J Cardiovasc Pharmacol. 1993 Jun;21(6):883-92. DOI:10.1097/00005344-199306000-00006
EMD 53998 Preparation Products And Raw materials
Raw materials
Preparation Products
EMD 53998 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TCI (Shanghai) Chemical Trading Co., Ltd. | 021-61109150 | sales@tcisct.com | China | 29668 | 58 |
| Supplier | Advantage |
|---|---|
| TCI (Shanghai) Chemical Trading Co., Ltd. | 58 |