Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>SIRT6-IN-3

SIRT6-IN-3

SIRT6-IN-3 Structure
SIRT6-IN-3 structure
CAS No.
3023471-40-8
Chemical Name:
SIRT6-IN-3
Synonyms
SIRT6-IN-3;Methanaminium, N-[[[6-[4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-1-yl]hexyl]thio](dimethylamino)methylene]-N-methyl-, bromide, hydrochloride (1:1:1)
CBNumber:
CB814291115
Molecular Formula:
C21H29Br2N6S.Br.ClH
Molecular Weight:
673.73
MDL Number:
MOL File:
3023471-40-8.mol
Last updated:2025-04-28 21:36:36
Request For Quotation

SIRT6-IN-3 Properties

form Solid
color Light yellow to yellow

SIRT6-IN-3 Chemical Properties,Uses,Production

Uses

SIRT6-IN-3 (compound 8a) is a selective inhibitor of SIRT6 (IC50=7.49 μM). SIRT6-IN-3 inhibits pancreatic ductal adenocarcinoma (PDAC) cells proliferation and induces apoptosis. SIRT6-IN-3 increases the sensitivity of cancer cells to gemcitabine (HY-17026) via blocking the DNA damage repair pathway. SIRT6-IN-3 is used in pancreatic cancer research[1].

in vivo

SIRT6-IN-3 (HY-156027; 20 mg/kg for i.p; once every 2 days for 4 weeks) has antitumor effects on tumor mouse model[1].
SIRT6-IN-3 (HY-156027; 20 mg/kg for i.p; once every 2 days for 4 weeks) enhances the antitumor effects of gemcitabine in vivo when in combination with gemcitabine (ratio 2 : 1)[1].

Animal Model:Tumor mouse model[1]
Dosage:20 mg/kg (in combination with 10 mg/kg gemcitabine)
Administration:Intraperitoneal injection (i.p.); Once every 2 days for 4 weeks
Result:Inhibited the tumor mass 71.3% in mice with combinations of gemcitabine.
Greatly increased the expression of apoptosis maker.

IC 50

SIRT1: 80.52 μM (IC50); SIRT2: 92.21 μM (IC50); SIRT6: 7.46 μM (IC50); HDAC3: 111.9 μM (IC50); HDAC6: 96.77 μM (IC50); HDAC8: 102 μM (IC50)

References

[1] Song N, et al. Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine. Cell Death Dis. 2023 Aug 4;14(8):499. DOI:10.1038/s41419-023-06018-1

SIRT6-IN-3 Preparation Products And Raw materials

Raw materials

Preparation Products

SIRT6-IN-3 Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19903 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 20701 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 58

View Lastest Price from SIRT6-IN-3 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SIRT6-IN-3 pictures 2025-04-28 SIRT6-IN-3
3023471-40-8
 US $0.00-0.00 / mg 10g TargetMol Chemicals Inc.
  • SIRT6-IN-3 pictures
  • SIRT6-IN-3
    3023471-40-8
  • US $0.00-0.00 / mg
  • TargetMol Chemicals Inc.
SIRT6-IN-3 Methanaminium, N-[[[6-[4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-1-yl]hexyl]thio](dimethylamino)methylene]-N-methyl-, bromide, hydrochloride (1:1:1) 3023471-40-8