13C20,15N10-Cyclic di-GMP (sodium salt)
- CAS No.
- Chemical Name:
- 13C20,15N10-Cyclic di-GMP (sodium salt)
- Synonyms
- 13C20,15N10-Cyclic di-GMP (sodium salt)
- CBNumber:
- CB815699642
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
13C20,15N10-Cyclic di-GMP (sodium salt) Chemical Properties,Uses,Production
Description
13C20,15N10-Cyclic di-GMP is intended for use as an internal standard for the quantification of cyclic di-GMP (Item No. 17144) by GC- or LC-MS. Cyclic di-GMP is a second messenger in bacteria involved in diverse prokaryotic processes, including biofilm formation, motility, virulence, and cell cycling.1,2 In eukaryotic cells, cyclic di-GMP is detected by and binds to the transmembrane protein stimulator of interferon genes (STING; Kd = 1.21 µM), leading to activation of the innate immune system.3,4 It has been used at a preset molar ratio with STING dimers in binding assays to determine the binding constants of particularly tight binding partners, such as 2’3’-cGAMP. Cyclic di-GMP induces IFN-β mRNA expression in vitro (EC50 = 537.8 nM) but less potently than 2’3’-cGAMP (Item No. 19887), 3’2’-cGAMP, 3’3’-cGAMP (Item No. 17966), and 2’2’-cGAMP (Item No. 22419).WARNING This product is not for human or veterinary use.
References
[1] UTE RÖMLING Mark G Michael Y Galperin. Cyclic di-GMP: the first 25 years of a universal bacterial second messenger.[J]. Microbiology and Molecular Biology Reviews, 2013, 77 1: 1-52. DOI: 10.1128/mmbr.00043-12
[2] LUARY C MARTÍNEZ V V. Mechanisms of post-transcriptional gene regulation in bacterial biofilms.[J]. ACS Applied Energy Materials, 2014: 38. DOI: 10.3389/fcimb.2014.00038
[3] SCHAAP P. Cyclic di-nucleotide signaling enters the eukaryote domain[J]. IUBMB Life, 2013, 65 11: 897-903. DOI: 10.1002/iub.1212
[4] XU ZHANG. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING.[J]. Molecular Cell, 2013, 51 2: 226-235. DOI: 10.1016/j.molcel.2013.05.022
13C20,15N10-Cyclic di-GMP (sodium salt) Preparation Products And Raw materials
Raw materials
Preparation Products
13C20,15N10-Cyclic di-GMP (sodium salt) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 6838 | 58 |
| Supplier | Advantage |
|---|---|
| Cayman Chemical Company | 58 |
