PD180970
- CAS No.
- 287204-45-9
- Chemical Name:
- PD180970
- Synonyms
- PD 180970;PD 180790;PF-1515965;PD-180970,PD180970;6-(2,6-dichlorophenyl)-2-(4-fluoro-3-methylanilino)-8-methylpyrido[2,3-d]pyrimidin-7-one;6-(2,6-DICHLORO-PHENYL)-2-(4-FLUORO-3-METHYL-PHENYLAMINO)-8-METHYL-8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE;6-(2,6-Dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one;PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, 6-(2,6-DICHLOROPHENYL)-2-[(4-FLUORO-3-METHYLPHENYL)AMINO]-8-METHYL-
- CBNumber:
- CB82454085
- Molecular Formula:
- C21H15Cl2FN4O
- Molecular Weight:
- 429.27
- MDL Number:
- MFCD10565929
- MOL File:
- 287204-45-9.mol
| Boiling point | 590.6±60.0 °C(Predicted) |
|---|---|
| Density | 1.449±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >20mg/mL |
| pka | 3.02±0.20(Predicted) |
| form | A solid |
| color | yellow |
| FDA UNII | TSO2IAD7WJ |
PD180970 price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PZ0142 | PD-180970 ≥98% (HPLC) | 287204-45-9 | 5mg | $155 | 2024-03-01 | Buy |
| Sigma-Aldrich | PZ0142 | PD-180970 ≥98% (HPLC) | 287204-45-9 | 25mg | $613 | 2024-03-01 | Buy |
| Usbiological | 462101 | PD 180970 | 287204-45-9 | 5mg | $382 | 2021-12-16 | Buy |
| TRC | P217825 | PD180970 | 287204-45-9 | 5mg | $100 | 2021-12-16 | Buy |
| AK Scientific | 2636BB | 6-(2,6-Dichlorophenyl)-2-[(4-Fluoro-3-Methylphenyl)amino]-8-Methylpyrido[2,3-D]pyrimidin-7(8h)-One | 287204-45-9 | 1mg | $133 | 2021-12-16 | Buy |
PD180970 Chemical Properties,Uses,Production
Uses
PD 180970 is an ATP-competitive inhibitor of p210 tyrosine kinase which selectively induces apoptosis in chronic myeloid leukemia (CML) K562 cells.
Enzyme inhibitor
This pyridopyrimidine (FWfree-base = 429.28 g/mol) inhibits Bcr-Abl proteintyrosine kinase and induces apoptosis of K562 leukemic cells. In vitro, PD180970 potently inhibited p210Bcr-Abl autophosphorylation (IC50 = 5 nM) as well as the kinase activity of purified Abl tyrosine kinase (IC50 = 2.2 nM). Incubation of K562 cells with PD180970 resulted in cell death, with results of nuclear staining, apoptotic-specific poly(ADP-ribose) polymerase cleavage, and annexin V binding assays confirming as much. Significantly, PD180970 is without effect on the growth and viability of p210Bcr-Ablnegative HL60 human leukemic cells. Such findings demonstrate that PD180970 is among the most potent known inhibitors of the p210Bcr-Abl tyrosine kinase and that it is a promising candidate as a novel therapeutic agent for Bcr-Abl-positive leukemia
PD180970 Preparation Products And Raw materials
Raw materials
Preparation Products
PD180970 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4692 | 58 |
| ShangHai KenEn Chemical Technology Co., Ltd. | 13120367189 | mychess007@163.com | China | 1994 | 55 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4182 | 55 | |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9708 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9838 | 58 |