Phenylbutazone-d10 (diphenyl-d10)
- CAS No.
- 1219794-69-0
- Chemical Name:
- Phenylbutazone-d10 (diphenyl-d10)
- Synonyms
- [2H10]-Phenylbutazone;[diphenyl-2H10]-Phenylbutazone;Phenylbutazone-d10 (diphenyl-d10)
- CBNumber:
- CB82538657
- Molecular Formula:
- C19H20N2O2
- Molecular Weight:
- 308.38
- MDL Number:
- MFCD00145102
- MOL File:
- 1219794-69-0.mol
Phenylbutazone-d10 (diphenyl-d10) price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | P319573 | Phenylbutazone(diphenyl-d10) | 1219794-69-0 | 25mg | $1810 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | RDL0007050 | PHENYLBUTAZONE-D10 95.00% | 1219794-69-0 | 5MG | $503.04 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | D925 | Phenylbutazone-d10(diphenyl-d10) | 1219794-69-0 | 0.01g | $730 | 2021-12-16 | Buy |
Phenylbutazone-d10 (diphenyl-d10) Chemical Properties,Uses,Production
Uses
Phenylbutazone(diphenyl-d10) is the isotope labelled analog of Phenylbutazone (P319570); a non-steroidal anti-inflammatory compound and an inhibitor of cyclooxygenase that is also a substrate for peroxidation by cyclooxygenase.
Biological Activity
Phenylbutazone-d10 (diphenyl) is the deuterium labeled Phenylbutazone. Phenylbutazone is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). Phenylbutazone, a hepatotoxin, is a nonsteroidal anti-inflammatory drug (NSAID). Phenylbutazone induces muscle blind-like protein 1 (MBNL1) expression and has the potential for ankylosing spondylitis research[1][2]. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.[2]. G A Reed, et al. Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for peroxidative metabolism. Mol Pharmacol. 1985 Jan;27(1):109-14.[3]. Guiying Chen, et al. Phenylbutazone induces expression of MBNL1 and suppresses formation of MBNL1-CUG RNA foci in a mouse model of myotonic dystrophy. Sci Rep. 2016 Apr 29;6:25317.[4]. Beretta C, et al. COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis. Pharmacol Res. 2005 Oct;52(4):302-6.
Phenylbutazone-d10 (diphenyl-d10) Preparation Products And Raw materials
Raw materials
Preparation Products
Phenylbutazone-d10 (diphenyl-d10) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Haolv Biotechnology Co.,Ltd | 025-84622273 02584622273; | kexin.zhou@haolvbiotech.com | China | 3021 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
| Qingdao Tenglong microwave technology co., LTD. | 0532-83818797 18561885118 | market@tlwb.com.cn | China | 3946 | 58 |
| ChengDu SinoStandards Bio-Tech Co.,Ltd. ， | 028-83243028 19136088901 | sinostandards@163.com | China | 5003 | 58 |
| Yancheng Tongming Biotechnology Co., Ltd. | 15195160625 | 2863565288@qq.com | China | 5194 | 58 |
| Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | czbjpharma@126.com | China | 18488 | 58 |
| Reer Technology (Shanghai) Co., LTD | 021-64400900 15800436310 | bessey@reertech.com | China | 4113 | 58 |
| Shanghai isotope chemical co.,ltd | 021-021-51600108 13062666369 | sales@chinaisotope.com | China | 4272 | 58 |