ChemicalBook >> CAS DataBase List >>6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
![6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile Structure](CAS/20200401/GIF/1207836-10-9.gif)
- CAS No.
- 1207836-10-9
- Chemical Name:
- 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
- Synonyms
- LOXO-292 intermediate;6-Bromo-4-methoxypyrazoL;Selpercatinib intermediate;o[1,5-a]pyridine-3-carbonitriL;6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonit;6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile;6-bromo-4-methoxypyrazolol[.5-alpyridine-3-carbonitrile;6-bromo-4-methoxypyrazole[1,5-a]pyridine-3-carbonitrile;6-Bromo-4-methoxypyrazolo [1,5-A] pyridine-3-acetonitrile;Pyrazolo[1,5-a]pyridine-3-carbonitrile, 6-bromo-4-methoxy-
- CBNumber:
- CB83143962
- Molecular Formula:
- C9H6BrN3O
- Molecular Weight:
- 252.07
- MDL Number:
- MFCD27937916
- MOL File:
- 1207836-10-9.mol
Last updated:2024-05-29 13:06:50
| Density | 1.67±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Sealed in dry,Room Temperature |
| pka | -1.97±0.30(Predicted) |
| InChI | InChI=1S/C9H6BrN3O/c1-14-8-2-7(10)5-13-9(8)6(3-11)4-12-13/h2,4-5H,1H3 |
| InChIKey | JTEWRYBKHXGXHP-UHFFFAOYSA-N |
| SMILES | C12=C(C#N)C=NN1C=C(Br)C=C2OC |
6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | 0400DP | 6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile | 1207836-10-9 | 5g | $1275 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0621203 | 6-BROMO-4-METHOXYPYRAZOLO[1,5-A]PYRIDINE-3-CARBONITRILE 95.00% | 1207836-10-9 | 5MG | $502.68 | 2021-12-16 | Buy |
| Ambeed | A866632 | 6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile 95% | 1207836-10-9 | 100g | $920 | 2021-12-16 | Buy |
| Chemenu | CM325273 | 6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile 95+% | 1207836-10-9 | 100g | $1263 | 2021-12-16 | Buy |
| Crysdot | CD11373512 | 6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile 98% | 1207836-10-9 | 5g | $1663 | 2021-12-16 | Buy |
6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile Chemical Properties,Uses,Production
Description
6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile is a pharmaceutical intermediate ingredient for the preparation of Selpercatinib, indicated for the treatment of patients with advanced cancers who test positive for certain RETs.
Uses
6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile is an organic intermediate for laboratory R&D processes.
Synthesis
The DMF 10L solution of 2,4,6-trimethylbenzenesulfonic acid 3-bromo-5-methoxypyridinamine salt 2000g (4.96mol, 1.0eq), 2-chloropropene cyanide (7.44mol, 1.5eq) was added with potassium carbonate 684g (4.96mol, 1.0eq) and stirred at 20-30°C for 8h. Then the mixtrue was heated with dropwise 1132g (7.44mol, 1.5eq) of diazabicyclo at 50-60°C for 20h. After the reaction is finished and poured into water 30 L at RT. the solution was filtered, washed with water and recrystallized in ethanol to give a pale yellow solid, 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile (702g 56%).
6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile Suppliers
Global( 137)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Million Pharmaceutical Co., Ltd | +86-531-68659554 +8613031714605 | info@millionpharm.com | China | 159 | 58 |
| Xiamen Yunfan Biotech Co.,Ltd. | +8618050056030 | yezhaobao@yfpharm.com | China | 20 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 19368 | 58 |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 971 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| Jinan Jianfeng Chemical Co., Ltd | 0531-88110457; +8615562555968 | info@pharmachemm.com | China | 225 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 13172 | 58 |
View Lastest Price from 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile pictures](/ProductImageEN/2023-08/Small/565444de-30e9-4baa-a6be-6e2a9afd3c14.png) |
2024-06-07 | 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
1207836-10-9
|
US $2.00 / kg | 1kg | 99% | 1200KG/M | Jinan Million Pharmaceutical Co., Ltd | |
![6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile pictures](/ProductImageEN/2024-03/Small/6cb8b3ae-0a58-445d-83c8-96758fc98e20.jpg) |
2024-06-07 | 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
1207836-10-9
|
US $75.00 / kg | 1kg | 99% | 2000kg | hebei hongtan Biotechnology Co., Ltd | |
 |
2024-06-07 | Selpercatinib intermediate
1207836-10-9
|
US $30.00 / kg | 1kg | 99% | 1000kg | hebei hongtan Biotechnology Co., Ltd |
-
- 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
1207836-10-9
- US $2.00 / kg
- 99%
- Jinan Million Pharmaceutical Co., Ltd
-
- 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
1207836-10-9
- US $75.00 / kg
- 99%
- hebei hongtan Biotechnology Co., Ltd
-
- Selpercatinib intermediate
1207836-10-9
- US $30.00 / kg
- 99%
- hebei hongtan Biotechnology Co., Ltd
6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
6-Bromo-4-methoxypyrazoL
o[1,5-a]pyridine-3-carbonitriL
Pyrazolo[1,5-a]pyridine-3-carbonitrile, 6-bromo-4-methoxy-
LOXO-292 intermediate
6-bromo-4-methoxypyrazole[1,5-a]pyridine-3-carbonitrile
6-bromo-4-methoxypyrazolol[.5-alpyridine-3-carbonitrile
6-Bromo-4-methoxypyrazolo [1,5-A] pyridine-3-acetonitrile
6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonit
Selpercatinib intermediate
1207836-10-9
1207863-10-9
1207836-10-9