MONOCLONAL ANTI-PHOSPHO-HISTONE H3 (PSER28)
- CAS No.
- Chemical Name:
- MONOCLONAL ANTI-PHOSPHO-HISTONE H3 (PSER28)
- Synonyms
- Monoclonal Anti-H3S28p;MONOCLONAL ANTI-PHOSPHO-HISTONE H3 (PSER28);Monoclonal Anti-phospho-Histone H3 (pSer28) antibody produced in rat
- CBNumber:
- CB8334505
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD03457568
- MOL File:
- Mol file
MONOCLONAL ANTI-PHOSPHO-HISTONE H3 (PSER28) price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H9908 | Monoclonal Anti-phospho-Histone H3 (pSer28) antibody produced in rat ~0.5?mg/mL, clone HTA28, purified immunoglobulin, buffered aqueous solution | 25μL | $174 | 2024-03-01 | Buy | |
| Sigma-Aldrich | H9908 | Monoclonal Anti-phospho-Histone H3 (pSer28) antibody produced in rat ~0.5?mg/mL, clone HTA28, purified immunoglobulin, buffered aqueous solution | 0.2mL | $606 | 2024-03-01 | Buy |
MONOCLONAL ANTI-PHOSPHO-HISTONE H3 (PSER28) Chemical Properties,Uses,Production
Uses
Monoclonal Anti-phospho-Histone H3 (pSer28) antibody is suitable for immunoblotting (approx. 15 kDa), immunocytochemistry (3.7% formaldehyde-methanol fixation) and flow cytometry applications.
General Description
Histone H1 and the N-terminal tail of histone-3 (H3) have key roles in the folding and inter-association of the chromatin fibers. Two currently known phosphorylation sites are present in the N-terminus of H3; serine-10 and serine-28. Mammals contain three main classes of histone H3 variants: the replicative histones (H3.1 and H3.2), the replacement histone (H3.3) and the centromeric histone (Cenp-A). Histone H3 is located on human chromosome 6p22.
Biochem/physiol Actions
Mitogenic stimulation, oncogenic transformation, or induction of oncogenic ras expression are accompanied with increase in serine-10 phosphorylation of the H3 N-terminal domain. It has been shown that phosphorylated H3 is associated with c-fos and c-myc genes in stimulated cells. Phosphorylation of H3, at both serine-10 and -28, coincides with the induction of mitotic chromosome condensation.H3 phosphorylation may contribute to proto-oncogene induction by modulating chromatin structure and releasing blocks in elongation. H3 dephosphorylation occurs quite rapidly after mitosis and serine-10/28 reo main unphosphorylated throughout the remainder of interphase. PP1 has been identified as the H3 phosphatase.
MONOCLONAL ANTI-PHOSPHO-HISTONE H3 (PSER28) Preparation Products And Raw materials
Raw materials
Preparation Products
MONOCLONAL ANTI-PHOSPHO-HISTONE H3 (PSER28) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Supplier | Advantage |
|---|---|
| Sigma-Aldrich | 80 |