2-(2,6-dioxopiperidin-3-yl)-4-(prop-2-yn-1-yloxy)isoindoline-1,3-dione

2-(2,6-dioxopiperidin-3-yl)-4-(prop-2-yn-1-yloxy)isoindoline-1,3-dione structure

CAS No.: 2098487-39-7

Chemical Name:: 2-(2,6-dioxopiperidin-3-yl)-4-(prop-2-yn-1-yloxy)isoindoline-1,3-dione

Synonyms: Thalidomide, propargyl;Thalidomide-4-propargyl;Thalidomide-4-O-propargyl;2-(2,6-dioxopiperidin-3-yl)-4-prop-2-ynoxyisoindole-1,3-dione;2-(2,6-Dioxo-3-piperidyl)-4-(2-propyn-1-yloxy)isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-(prop-2-yn-1-yloxy)isoindoline-1,3-dione;2-(2,6-Dioxo-3-piperidinyl)-4-(2-propyn-1-yloxy)-1H-isoindole-1,3(2H)-dione;1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-(2-propyn-1-yloxy)-;2-(6-hydroxy-2-oxo-2,3,4,5-tetrahydropyridin-3-yl)-4-(prop-2-yn-1-yloxy)isoindoline-1,3-dione;Thalidomide-propargyl,Inhibitor,Thalidomide propargyl,E3 ligase-recruiting Moiety,Thalidomidepropargyl,inhibit,Ligands for E3 Ligase

CBNumber:: CB83353206

Molecular Formula:: C16H12N2O5

Molecular Weight:: 312.28

MDL Number:: MFCD32063450

MOL File:: 2098487-39-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-22 18:57:36

Product description	Number	Pack Size	Price
Thalidomide,propargyl ≥95%(HPLC)	6685	50	$439

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2-(2,6-dioxopiperidin-3-yl)-4-(prop-2-yn-1-yloxy)isoindoline-1,3-dione Properties

Boiling point	590.2±50.0 °C(Predicted)
Density	1.469±0.06 g/cm3(Predicted)
form	Solid
pka	10.68±0.40(Predicted)
color	White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319
Precautionary statements	P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

2-(2,6-dioxopiperidin-3-yl)-4-(prop-2-yn-1-yloxy)isoindoline-1,3-dione price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Tocris	6685	Thalidomide,propargyl ≥95%(HPLC)	2098487-39-7	50	$439	2021-12-16	Buy

Product number	Packaging	Price	Buy
6685	50	$439	Buy

2-(2,6-dioxopiperidin-3-yl)-4-(prop-2-yn-1-yloxy)isoindoline-1,3-dione Chemical Properties,Uses,Production

Description

Thalidomide-propargyl is an alkyne-functionalized Thalidomide.

Uses

Thalidomide-propargyl is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-propargyl can be connected to the ligand for protein by a linker to form the IMiD containing PROTACs[1]. Thalidomide-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

Cereblon

storage

Store at -20°C

References

[1] Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461. DOI:10.1021/acs.jmedchem.6b01781

2-(2,6-dioxopiperidin-3-yl)-4-(prop-2-yn-1-yloxy)isoindoline-1,3-dione Preparation Products And Raw materials

Raw materials

Preparation Products

2-(2,6-dioxopiperidin-3-yl)-4-(prop-2-yn-1-yloxy)isoindoline-1,3-dione Suppliers

Global( 46)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32467	58
CR Corporation Limited	+8613062833949	fred.wen@crcorporation.cn	China	8645	58
Zhengzhou Lingzhiyue Technology Co., Ltd	+86-0371-55074660 +86-13523716970	Lingzhiyue@aliyun.com	China	3145	58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd	+8618235132063	sales@tihondan.com	China	3767	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42056	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Shaanxi Dideu New Materials Co. Ltd	+86-18192503167 18192503167;	1036@dideu.com	China	7917	58
Shanghai Joy Biotech Ltd.	+86-15968534750 +86-1358845959750	sales@joybiotech.com	China	1000	58
Daicel Chiral Technologies (China)CO.,LTD	021-50460086-9 15921403865	han_yajun@dctc.daicel.com	China	7440	65

Supplier	Advantage
BOC Sciences	58
TargetMol Chemicals Inc.	58
CR Corporation Limited	58
Zhengzhou Lingzhiyue Technology Co., Ltd	58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd	58
Jilin Chinese Academy of Sciences-yanshen Technology	58
Aladdin Scientific	58
Shaanxi Dideu New Materials Co. Ltd	58
Shanghai Joy Biotech Ltd.	58
Daicel Chiral Technologies (China)CO.,LTD	65

View Lastest Price from 2-(2,6-dioxopiperidin-3-yl)-4-(prop-2-yn-1-yloxy)isoindoline-1,3-dione manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-04-22	Thalidomide-propargyl 2098487-39-7	US $46.00-139.00 / mg		95.01%	10g	TargetMol Chemicals Inc.
	2025-12-01	2-(2,6-dioxopiperidin-3-yl)-4-(prop-2-yn-1-yloxy)isoindoline-1,3-dione 2098487-39-7	US $0.00 / kg	1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

Thalidomide-propargyl
2098487-39-7
US $46.00-139.00 / mg
95.01%
TargetMol Chemicals Inc.

2-(2,6-dioxopiperidin-3-yl)-4-(prop-2-yn-1-yloxy)isoindoline-1,3-dione
2098487-39-7
US $0.00 / kg
99%
Shaanxi Dideu New Materials Co. Ltd

2-(2,6-dioxopiperidin-3-yl)-4-(prop-2-yn-1-yloxy)isoindoline-1,3-dione Spectrum

2-(2,6-dioxopiperidin-3-yl)-4-(prop-2-yn-1-yloxy)isoindoline-1,3-dione(2098487-39-7)¹HNMR

2098487-39-7(2-(2,6-dioxopiperidin-3-yl)-4-(prop-2-yn-1-yloxy)isoindoline-1,3-dione)Related Search:

Thalidomide-O-amido-C2-NH2 4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione -alkylC5-amine Thalidomide-NH-C6-NH2 TFA 4-[(6-Aminohexyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl

E3 ligase Ligand-Linker Conjugates 15 Thalidomide-O-amido-C2-NH2 Thalidomide-NH-PEG2-C2-NH2 hydrochloride Thalidomide-NH-PEG2-C2-NH2 (TFA)

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2-(2,6-dioxopiperidin-3-yl)-4-(prop-2-yn-1-yloxy)isoindoline-1,3-dione Thalidomide, propargyl 2-(2,6-Dioxo-3-piperidinyl)-4-(2-propyn-1-yloxy)-1H-isoindole-1,3(2H)-dione 2-(2,6-dioxopiperidin-3-yl)-4-prop-2-ynoxyisoindole-1,3-dione Thalidomide-4-propargyl Thalidomide-propargyl,Inhibitor,Thalidomide propargyl,E3 ligase-recruiting Moiety,Thalidomidepropargyl,inhibit,Ligands for E3 Ligase 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-(2-propyn-1-yloxy)- 2-(6-hydroxy-2-oxo-2,3,4,5-tetrahydropyridin-3-yl)-4-(prop-2-yn-1-yloxy)isoindoline-1,3-dione Thalidomide-4-O-propargyl 2-(2,6-Dioxo-3-piperidyl)-4-(2-propyn-1-yloxy)isoindoline-1,3-dione 2098487-39-7