Anti-IDH1/2 Mutant (R132/172) Antibody, clone MsMab-1

CAS No.
Chemical Name:
Anti-IDH1/2 Mutant (R132/172) Antibody, clone MsMab-1
Synonyms
Anti-IDH1/2 Mutant (R132/172) Antibody, clone MsMab-1
CBNumber:
CB84816205
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file

Anti-IDH1/2 Mutant (R132/172) Antibody, clone MsMab-1 price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich MABC1103 Anti-IDH1/2 Mutant (R132/172) Antibody, clone MsMab-1 clone MsMAb-1, from mouse 100μg $416 2024-03-01 Buy
Product number Packaging Price Buy
MABC1103 100μg $416 Buy

Anti-IDH1/2 Mutant (R132/172) Antibody, clone MsMab-1 Chemical Properties,Uses,Production

Uses

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected IDH1/2 Mutant (R132/172) in human colon, human colorectal cancer, and human ovarian cancer tissue.
Western Blotting Analysis: The mutant selectivity of a representative lot was tested against purified IDH1/2 MBP fusion constructs as well as lysates from CHO cells expressing exogenously expressed IDH1/2 proteins (Kato Kaneko, M., et al. (2013). Tohoku J Exp Med. 230(2):103-109; Liu, X., et al. (2013). Cancer Med.;2(6):803-814).
Western Blotting Analysis: A representative lot detected exogenously expressed IDH2- R172S, but not wild-type IDH2 or IDH2-H175Y PA fusion proteins in lysates from transfected U2OS osteosarcoma cells (Kato Kaneko, M., et al. (2014). Cancer Sci.;105(6):744-748).
Immunohistochemistry Analysis: A representative lot detected IDH2 R172S mutant, but not wild-type IDH1/2, in paraffin-embedded human GCTB (giant cell tumor of bone) tissue sections (Kato Kaneko, M., et al. (2014). Cancer Sci.;105(6):744-748).
Immunohistochemistry Analysis: A representative lot detected IDH2 R172S mutant, but not wild-type IDH1/2, in paraffin-embedded human osteosarcoma tissue sections (Liu, X., et al. (2013). Cancer Med.;2(6):803-814).

General Description

Isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate to produce alpha-ketoglutarate and carbon dioxide. There exist three forms of IDHs in human (IDH1-3), with IDH3 utilizing NAD+ as a cofactor and functioning within the citric acid cycle, while IDH1 (EC 1.1.1.42; UniProt P48735) and IDH2 (EC 1.1.1.42; UniProt P48735) utilizing NADP+ as a cofactor and functioning outside the context of the citric acid cycle. Mutated IDH1 and IDH2 convert alpha-ketoglutarate to oncometabolite R(-)-2-hydroxyglutarate (2-HG) in cytosol and mitochondria, respectively. Isocitrate dehydrogenase 1 ? 2 mutations have been reported in gliomas, acute myeloid leukemias (AMLs), cartilaginous tumors, osteosarcoma, Giant cell tumors of bone (GCTB), Ollier disease, and Maffucci syndrome.

Anti-IDH1/2 Mutant (R132/172) Antibody, clone MsMab-1 Preparation Products And Raw materials

Raw materials

Preparation Products

Anti-IDH1/2 Mutant (R132/172) Antibody, clone MsMab-1 Suppliers

Global( 2)Suppliers
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Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Supplier Advantage
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Anti-IDH1/2 Mutant (R132/172) Antibody, clone MsMab-1